Page last updated: 2024-10-25

deferoxamine and Atherogenesis

deferoxamine has been researched along with Atherogenesis in 6 studies

Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (50.00)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Li, L2
Frei, B3
Zhang, WJ1
Wei, H1
Fan, Y1
Wang, J1
Wei, L1
He, B1
Wang, C1
Wang, B1
Satchell, L1
Leake, DS1
Li, W1
Hellsten, A1
Xu, LH1
Zhuang, DM1
Jansson, K1
Brunk, UT1
Yuan, XM1

Other Studies

6 other studies available for deferoxamine and Atherogenesis

ArticleYear
Prolonged exposure to LPS increases iron, heme, and p22phox levels and NADPH oxidase activity in human aortic endothelial cells: inhibition by desferrioxamine.
    Arteriosclerosis, thrombosis, and vascular biology, 2009, Volume: 29, Issue:5

    Topics: Aorta; Atherosclerosis; Cells, Cultured; Deferoxamine; Endothelial Cells; Heme; Humans; Iron; Lipopo

2009
The iron chelator, desferrioxamine, reduces inflammation and atherosclerotic lesion development in experimental mice.
    Experimental biology and medicine (Maywood, N.J.), 2010, Volume: 235, Issue:5

    Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Chemokine CCL2; Cholesterol; Deferoxamine; Femal

2010
Iron deficiency activates pro-inflammatory signaling in macrophages and foam cells via the p38 MAPK-NF-κB pathway.
    International journal of cardiology, 2011, Oct-06, Volume: 152, Issue:1

    Topics: Acute Coronary Syndrome; Atherosclerosis; Basigin; Cell Line; Deferoxamine; Foam Cells; Gene Express

2011
Oxidation of low-density lipoprotein by iron at lysosomal pH: implications for atherosclerosis.
    Biochemistry, 2012, May-08, Volume: 51, Issue:18

    Topics: alpha-Tocopherol; Atherosclerosis; Chlorides; Deferoxamine; Ferric Compounds; Ferrous Compounds; Hyd

2012
Foam cell death induced by 7beta-hydroxycholesterol is mediated by labile iron-driven oxidative injury: mechanisms underlying induction of ferritin in human atheroma.
    Free radical biology & medicine, 2005, Oct-01, Volume: 39, Issue:7

    Topics: Animals; Apoptosis; Atherosclerosis; Deferoxamine; Ferritins; Foam Cells; Humans; Hydroxycholesterol

2005
Iron chelation inhibits NF-kappaB-mediated adhesion molecule expression by inhibiting p22(phox) protein expression and NADPH oxidase activity.
    Arteriosclerosis, thrombosis, and vascular biology, 2006, Volume: 26, Issue:12

    Topics: Animals; Atherosclerosis; Cell Adhesion Molecules; Cytochrome b Group; Deferoxamine; Female; Gene Ex

2006