deferoxamine has been researched along with Anterior Choroidal Artery Infarction in 6 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rat model of cerebral ischemia was established by middle cerebral artery occlusion with or without DFO administration." | 1.35 | Desferoxamine preconditioning protects against cerebral ischemia in rats by inducing expressions of hypoxia inducible factor 1 alpha and erythropoietin. ( Ding, SJ; Guo, W; Li, YX; Xiao, L; Zhan, Q, 2008) |
| "Nimodipine was given at a dose of 1 mg/kg 1 hour before and 2 hours after the cold lesion." | 1.29 | Proposed toxic oxidant inhibitors fail to reduce brain edema. ( Bulkley, GB; Hedlund, BE; Judy, KD; Long, DM, 1994) |
| "The area of cerebral infarction was measured at three levels using video imaging methods." | 1.29 | Failure of iron chelators to protect against cerebral infarction in hypoxia-ischemia. ( Davis, J; Fridovich, I; MacMillan, V, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, SJ | 1 |
| Jeong, HJ | 1 |
| Moon, PD | 1 |
| Lee, KM | 1 |
| Moon, BS | 1 |
| Myung, NY | 1 |
| An, NH | 1 |
| Hong, SH | 1 |
| Um, JY | 1 |
| Kim, HM | 1 |
| Li, YX | 1 |
| Ding, SJ | 1 |
| Xiao, L | 1 |
| Guo, W | 1 |
| Zhan, Q | 1 |
| Judy, KD | 1 |
| Bulkley, GB | 1 |
| Hedlund, BE | 1 |
| Long, DM | 1 |
| MacMillan, V | 1 |
| Fridovich, I | 1 |
| Davis, J | 1 |
| Powars, DR | 1 |
| Wong, WY | 1 |
| Vachon, LA | 1 |
| Soloniuk, DS | 1 |
| Perkins, E | 1 |
| Wilson, JR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Double-blind, Randomized, Placebo Controlled, Dose-finding Phase 2 Clinical Trial of Intravenous Deferoxamine in Patients With Acute Ischemic Stroke Treated With Tissue Plasminogen Activator[NCT00777140] | Phase 2 | 62 participants (Actual) | Interventional | 2008-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for deferoxamine and Anterior Choroidal Artery Infarction
| Article | Year |
|---|---|
Effect of Danchunwhangagam on LPS or DFX-induced cytokine production in peripheral mononuclear cells of cerebral infarction patients.
Topics: Aged; Cells, Cultured; Cerebral Infarction; Cytokines; Deferoxamine; Dose-Response Relationship, Dru | 2005 |
Desferoxamine preconditioning protects against cerebral ischemia in rats by inducing expressions of hypoxia inducible factor 1 alpha and erythropoietin.
Topics: Animals; Brain Ischemia; Cells, Cultured; Cerebral Infarction; Deferoxamine; Disease Models, Animal; | 2008 |
Proposed toxic oxidant inhibitors fail to reduce brain edema.
Topics: Allopurinol; Animals; Brain Edema; Brain Injuries; Calcium; Cats; Cerebral Cortex; Cerebral Infarcti | 1994 |
Failure of iron chelators to protect against cerebral infarction in hypoxia-ischemia.
Topics: Animals; Brain; Brain Ischemia; Carbon Monoxide; Cerebral Infarction; Deferoxamine; Hypoxia, Brain; | 1993 |
Incomplete cerebral infarctions are not silent.
Topics: Adolescent; Anemia, Sickle Cell; Blood Flow Velocity; Bone Marrow Transplantation; Brain Damage, Chr | 2001 |
Use of allopurinol and deferoxamine in cellular protection during ischemia.
Topics: Allopurinol; Animals; Brain Ischemia; Cell Death; Cerebral Infarction; Deferoxamine; Rats | 1992 |