deferoxamine has been researched along with Amyloid Deposits in 3 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neuritic plaques are the key pathological feature of Alzheimer's disease, and amyloid beta (Abeta) peptides are major component of these plaques." | 1.33 | Aluminum inhibits proteolytic degradation of amyloid beta peptide by cathepsin D: a potential link between aluminum accumulation and neuritic plaque deposition. ( Ishii, K; Ogasawara, Y; Saito, H; Sakamoto, T; Takahashi, H; Tanabe, S, 2006) |
| "Pretreatment with deferoxamine or diethylenetriaminepentaacetic acid abolishes the ability of the lesions to catalyze the H2O2-dependent oxidation of 3,3'-diaminobenzidine (DAB), strongly suggesting the involvement of associated transition metal ions." | 1.31 | In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: a central role for bound transition metals. ( Harris, PL; Liu, Y; Perry, G; Sayre, LM; Schubert, KA; Smith, MA, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Meadowcroft, MD | 1 |
| Peters, DG | 1 |
| Dewal, RP | 1 |
| Connor, JR | 1 |
| Yang, QX | 1 |
| Sakamoto, T | 1 |
| Saito, H | 1 |
| Ishii, K | 1 |
| Takahashi, H | 1 |
| Tanabe, S | 1 |
| Ogasawara, Y | 1 |
| Sayre, LM | 1 |
| Perry, G | 1 |
| Harris, PL | 1 |
| Liu, Y | 1 |
| Schubert, KA | 1 |
| Smith, MA | 1 |
3 other studies available for deferoxamine and Amyloid Deposits
| Article | Year |
|---|---|
The effect of iron in MRI and transverse relaxation of amyloid-beta plaques in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Case-Control Studies; Deferoxamine; Humans; Iron; Magnetic Resonance Imagin | 2015 |
Aluminum inhibits proteolytic degradation of amyloid beta peptide by cathepsin D: a potential link between aluminum accumulation and neuritic plaque deposition.
Topics: Aluminum; Amyloid beta-Peptides; Cathepsin D; Chromatography, High Pressure Liquid; Circular Dichroi | 2006 |
In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: a central role for bound transition metals.
Topics: 3,3'-Diaminobenzidine; Aged; Aged, 80 and over; Alzheimer Disease; Catalysis; Chelating Agents; Copp | 2000 |