deferoxamine has been researched along with Acute Liver Injury, Drug-Induced in 31 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report a prospective, randomized, Phase II study of deferasirox and deferoxamine (DFO) in sickle cell disease patients with transfusional iron overload, with all patients continuing on deferasirox after 24 weeks, for up to 2 years." | 5.17 | Efficacy and safety of deferasirox compared with deferoxamine in sickle cell disease: two-year results including pharmacokinetics and concomitant hydroxyurea. ( Barrette, S; Files, B; Habr, D; Minniti, CP; Torres, M; Vichinsky, E; Zhang, Y, 2013) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| " DFO at a dosing level equivalent to 10-fold of that of DXR was useful to obtain protective effects." | 1.31 | The preventive role of deferoxamine against acute doxorubicin-induced cardiac, renal and hepatic toxicity in rats. ( Al-Rikabi, AC; Najjar, TA; Saad, SY, 2001) |
| " Lindane (25-60 mg/kg) at 24 h after dosage induced a dose-dependent increase in oxygen consumption by perfused rat livers, an effect not observed at early times (2-6 h) after administration." | 1.28 | Mechanisms of lindane-induced hepatotoxicity: alterations of respiratory activity and sinusoidal glutathione efflux in the isolated perfused rat liver. ( Barros, SB; Junqueira, VB; Simizu, K; Videla, LA, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (35.48) | 18.7374 |
| 1990's | 6 (19.35) | 18.2507 |
| 2000's | 4 (12.90) | 29.6817 |
| 2010's | 9 (29.03) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Adelusi, OB | 1 |
| Ramachandran, A | 1 |
| Lemasters, JJ | 2 |
| Jaeschke, H | 2 |
| Umemura, M | 1 |
| Kim, JH | 1 |
| Aoyama, H | 1 |
| Hoshino, Y | 1 |
| Fukumura, H | 1 |
| Nakakaji, R | 1 |
| Sato, I | 1 |
| Ohtake, M | 1 |
| Akimoto, T | 1 |
| Narikawa, M | 1 |
| Tanaka, R | 1 |
| Fujita, T | 1 |
| Yokoyama, U | 1 |
| Taguri, M | 1 |
| Okumura, S | 1 |
| Sato, M | 1 |
| Eguchi, H | 1 |
| Ishikawa, Y | 1 |
| Vichinsky, E | 1 |
| Torres, M | 1 |
| Minniti, CP | 1 |
| Barrette, S | 1 |
| Habr, D | 1 |
| Zhang, Y | 1 |
| Files, B | 1 |
| Kumfu, S | 1 |
| Chattipakorn, SC | 1 |
| Fucharoen, S | 1 |
| Chattipakorn, N | 1 |
| Hu, J | 1 |
| Kholmukhamedov, A | 1 |
| Lindsey, CC | 1 |
| Beeson, CC | 1 |
| Najafzadeh, H | 1 |
| Jalali, MR | 1 |
| Morovvati, H | 1 |
| Taravati, F | 1 |
| BARR, DG | 1 |
| FRASER, DK | 1 |
| Hershko, CM | 1 |
| Link, GM | 1 |
| Konijn, AM | 1 |
| Cabantchik, ZI | 1 |
| Wood, DM | 1 |
| Thomson, AH | 1 |
| Lawes, M | 1 |
| Jones, AL | 1 |
| Dargan, PI | 1 |
| Henretig, FM | 1 |
| Temple, AR | 1 |
| Sakaida, I | 1 |
| Kayano, K | 1 |
| Wasaki, S | 1 |
| Nagatomi, A | 1 |
| Matsumura, Y | 1 |
| Okita, K | 1 |
| Omara, FO | 1 |
| Blakley, BR | 1 |
| Mansour, MA | 1 |
| Saad, SY | 1 |
| Najjar, TA | 1 |
| Al-Rikabi, AC | 1 |
| Gratadour, P | 1 |
| Fouque, D | 1 |
| Chevalier, P | 1 |
| Vial, T | 1 |
| Chossegros, P | 1 |
| Laville, M | 1 |
| Labeeuw, M | 1 |
| Zech, P | 1 |
| Videla, LA | 1 |
| Simizu, K | 1 |
| Barros, SB | 1 |
| Junqueira, VB | 1 |
| Younes, M | 4 |
| Wess, A | 1 |
| Strubelt, O | 1 |
| Banner, W | 1 |
| Tong, TG | 1 |
| Tenenbein, M | 1 |
| Israels, SJ | 1 |
| Nakae, D | 1 |
| Oakes, JW | 1 |
| Farber, JL | 1 |
| Siegers, CP | 2 |
| Steffen, B | 1 |
| Brennaman, B | 1 |
| Soucy, D | 1 |
| Howard, RJ | 1 |
| Schmidt, UJ | 2 |
| Kranz, D | 2 |
| Brüschke, G | 2 |
| Kalbe, I | 1 |
| Rürup, B | 1 |
| Haase, J | 1 |
| Ihle, R | 1 |
| Walsh, JR | 1 |
| Gillick, JB | 1 |
2 reviews available for deferoxamine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Iron poisoning.
Topics: Absorption; Bicarbonates; Chemical and Drug Induced Liver Injury; Child, Preschool; Deferoxamine; Di | 1986 |
1 trial available for deferoxamine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Efficacy and safety of deferasirox compared with deferoxamine in sickle cell disease: two-year results including pharmacokinetics and concomitant hydroxyurea.
Topics: Acute Kidney Injury; Adolescent; Adult; Anemia, Sickle Cell; Benzoates; Cellulitis; Chelation Therap | 2013 |
28 other studies available for deferoxamine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
The iron chelating agent, deferoxamine detoxifies Fe(Salen)-induced cytotoxicity.
Topics: Acute Kidney Injury; Animals; Antidotes; Antineoplastic Agents; Chelating Agents; Chemical and Drug | 2017 |
Effects of iron overload condition on liver toxicity and hepcidin/ferroportin expression in thalassemic mice.
Topics: Animals; bcl-2-Associated X Protein; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Cha | 2016 |
Translocation of iron from lysosomes to mitochondria during acetaminophen-induced hepatocellular injury: Protection by starch-desferal and minocycline.
Topics: Acetaminophen; Animals; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Defe | 2016 |
Comparison of the prophylactic effect of silymarin and deferoxamine on iron overload-induced hepatotoxicity in rat.
Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug | 2010 |
MANAGEMENT OF ACUTE IRON POISONING.
Topics: Chemical and Drug Induced Liver Injury; Deferoxamine; Hepatitis; Hepatitis A; Iron; Iron Metabolism | 1965 |
Iron chelation therapy.
Topics: Administration, Oral; Benzoates; beta-Thalassemia; Chelation Therapy; Chemical and Drug Induced Live | 2005 |
Hepatocellular damage following therapeutic intravenous iron sucrose infusion in a child.
Topics: Anemia, Iron-Deficiency; Chemical and Drug Induced Liver Injury; Child, Preschool; Deferoxamine; Fer | 2005 |
Acute iron poisoning in children.
Topics: Cardiovascular Diseases; Cathartics; Central Nervous System Diseases; Chemical and Drug Induced Live | 1984 |
Protection against acetaminophen-induced liver injury in vivo by an iron chelator, deferoxamine.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Deferoxamine; | 1995 |
Vitamin E is protective against iron toxicity and iron-induced hepatic vitamin E depletion in mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Deferoxamine; Diet; Iron; Liver; Liver Diseases; Ma | 1993 |
Protective effects of thymoquinone and desferrioxamine against hepatotoxicity of carbon tetrachloride in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzoquinones; Carbon Tetrachloride; Che | 2000 |
The preventive role of deferoxamine against acute doxorubicin-induced cardiac, renal and hepatic toxicity in rats.
Topics: Analysis of Variance; Animals; Chelating Agents; Chemical and Drug Induced Liver Injury; Deferoxamin | 2001 |
[Acute hepatitis induced by deferoxamine in a patient under chronic hemodialysis].
Topics: Acute Disease; Aged; Chemical and Drug Induced Liver Injury; Deferoxamine; Hemodialysis, Home; Human | 1992 |
Mechanisms of lindane-induced hepatotoxicity: alterations of respiratory activity and sinusoidal glutathione efflux in the isolated perfused rat liver.
Topics: Animals; Chemical and Drug Induced Liver Injury; Deferoxamine; Dose-Response Relationship, Drug; Glu | 1991 |
The role of iron in t-butyl hydroperoxide-induced lipid peroxidation and hepatotoxicity in rats.
Topics: Alanine Transaminase; Animals; Calcium; Chemical and Drug Induced Liver Injury; Deferoxamine; Ethane | 1990 |
The role of iron and glutathione in t-butyl hydroperoxide-induced damage towards isolated perfused rat livers.
Topics: Alanine Transaminase; Animals; Calcium; Chemical and Drug Induced Liver Injury; Deferoxamine; Glutam | 1990 |
Early coagulopathy in severe iron poisoning.
Topics: Adolescent; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Child, Preschool; D | 1988 |
Potentiation in the intact rat of the hepatotoxicity of acetaminophen by 1,3-bis(2-chloroethyl)-1-nitrosourea.
Topics: Acetaminophen; Animals; Carmustine; Chemical and Drug Induced Liver Injury; Deferoxamine; Drug Syner | 1988 |
Antidotal effects of deferrioxamine in experimental liver injury--role of lipid peroxidation.
Topics: Animals; Antidotes; Chemical and Drug Induced Liver Injury; Deferoxamine; Lipid Peroxides; Liver; Ma | 1988 |
Effect of iron and liver injury on the pathogenesis of Vibrio vulnificus.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chlorides; Deferoxa | 1987 |
The role of iron in the paracetamol- and CCl4-induced lipid peroxidation and hepatotoxicity.
Topics: Acetaminophen; Animals; Breath Tests; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 1985 |
[Liver parenchyma damage by treatment with desferrioxamine B].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; | 1969 |
[Damage to the liver parenchyma induced by desferrioxamine B therapy].
Topics: Chemical and Drug Induced Liver Injury; Deferoxamine; Hemosiderosis; Humans; Liver | 1968 |
Iron chelation in acute iron poisoning and chronic hypersiderosis.
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Deferoxamine; Female; H | 1965 |