deferoxamine has been researched along with Acute Brain Injuries in 21 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Deferoxamine may be a therapy for patients with IVH or intraventricular extension after intracerebral hemorrhage." | 3.77 | Role of iron in brain injury after intraventricular hemorrhage. ( Chen, Z; Gao, C; Hua, Y; Keep, RF; Muraszko, K; Xi, G, 2011) |
| "Deferoxamine (DFX) has recently been shown to have a neuroprotective effect in animal models of subarachnoid haemorrhage (SAH)." | 1.40 | Possible involvement of cathepsin B/D and caspase-3 in deferoxamine-related neuroprotection of early brain injury after subarachnoid haemorrhage in rats. ( Chen, G; Jia, Y; Yu, ZQ, 2014) |
| "Deferoxamine treatment attenuated TBI-induced hydrocephalus and heme oxygenase-1 upregulation." | 1.40 | Deferoxamine attenuates acute hydrocephalus after traumatic brain injury in rats. ( Chen, Z; Hua, Y; Keep, RF; Xi, G; Zhao, J, 2014) |
| "Nimodipine was given at a dose of 1 mg/kg 1 hour before and 2 hours after the cold lesion." | 1.29 | Proposed toxic oxidant inhibitors fail to reduce brain edema. ( Bulkley, GB; Hedlund, BE; Judy, KD; Long, DM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (38.10) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 10 (47.62) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Jones, NM | 1 |
| Nathanson, AD | 1 |
| Chell, S | 1 |
| DeAngelis, E | 1 |
| Whelan, G | 1 |
| Willé, D | 1 |
| Cheng, K | 1 |
| Yu, X | 1 |
| Ma, X | 1 |
| Lyu, J | 1 |
| Jiang, N | 1 |
| Lu, Y | 1 |
| Liao, Y | 1 |
| Wang, K | 1 |
| Yu, W | 1 |
| Zhu, Q | 1 |
| Gong, Y | 1 |
| Guo, T | 1 |
| Deng, J | 1 |
| Ji, J | 1 |
| Wang, B | 1 |
| Hao, S | 1 |
| Kapoor, S | 1 |
| Yu, ZQ | 1 |
| Jia, Y | 1 |
| Chen, G | 1 |
| Zhao, J | 1 |
| Chen, Z | 2 |
| Xi, G | 4 |
| Keep, RF | 3 |
| Hua, Y | 4 |
| Egashira, Y | 1 |
| Chaudhary, N | 1 |
| Pandey, AS | 1 |
| Li, Y | 1 |
| Yang, H | 1 |
| Ni, W | 1 |
| Gu, Y | 1 |
| Ohnishi, M | 1 |
| Katsuki, H | 1 |
| Unemura, K | 1 |
| Izumi, Y | 1 |
| Kume, T | 1 |
| Takada-Takatori, Y | 1 |
| Akaike, A | 1 |
| Gao, C | 1 |
| Muraszko, K | 1 |
| Lee, JY | 1 |
| Ernestus, RI | 1 |
| Zhang, L | 1 |
| Hu, R | 1 |
| Li, M | 1 |
| Li, F | 1 |
| Meng, H | 1 |
| Zhu, G | 1 |
| Lin, J | 1 |
| Feng, H | 1 |
| Judy, KD | 1 |
| Bulkley, GB | 1 |
| Hedlund, BE | 1 |
| Long, DM | 2 |
| Long, DA | 1 |
| Ghosh, K | 1 |
| Moore, AN | 1 |
| Dixon, CE | 1 |
| Dash, PK | 1 |
| Regan, RF | 1 |
| Panter, SS | 1 |
| Heegaard, W | 1 |
| Biros, M | 1 |
| Zink, J | 1 |
| Rauhala, P | 1 |
| Khaldi, A | 1 |
| Mohanakumar, KP | 1 |
| Chiueh, CC | 1 |
| Hoffman, SW | 1 |
| Rzigalinski, BA | 1 |
| Willoughby, KA | 1 |
| Ellis, EF | 1 |
| Kontos, HA | 1 |
| Wei, EP | 1 |
| Kirsch, JR | 1 |
| Helfaer, MA | 1 |
| Lange, DG | 1 |
| Traystman, RJ | 1 |
| Ikeda, Y | 1 |
1 review available for deferoxamine and Acute Brain Injuries
| Article | Year |
|---|---|
Evidence for free radical mechanisms of brain injury resulting from ischemia/reperfusion-induced events.
Topics: Animals; Brain; Brain Injuries; Brain Ischemia; Deferoxamine; Free Radical Scavengers; Free Radicals | 1992 |
20 other studies available for deferoxamine and Acute Brain Injuries
| Article | Year |
|---|---|
The prolyl hydroxylase inhibitor GSK1120360A reduces early brain injury, but protection is not maintained in a neonatal rat model of hypoxic ischaemic encephalopathy.
Topics: Animals; Animals, Newborn; Brain; Brain Injuries; Deferoxamine; Hypoxia; Hypoxia-Ischemia, Brain; Me | 2022 |
Ferroptosis involved in sevoflurane-aggravated young rats brain injury induced by liver transplantation.
Topics: Animals; Brain Injuries; Child; Deferoxamine; Ferroptosis; Humans; Iron; Ischemia; Liver; Liver Tran | 2022 |
Thermo-sensitive keratin hydrogel against iron-induced brain injury after experimental intracerebral hemorrhage.
Topics: Acrylic Resins; Adsorption; Animals; Behavior, Animal; Brain; Brain Injuries; Cerebral Hemorrhage; D | 2019 |
Deferoxamine: emerging, new neuro-protective benefits.
Topics: Animals; Brain Injuries; Deferoxamine; Iron; Male; Neurotoxicity Syndromes; Siderophores | 2013 |
Possible involvement of cathepsin B/D and caspase-3 in deferoxamine-related neuroprotection of early brain injury after subarachnoid haemorrhage in rats.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Brain Injuries; Caspase 3; Cathepsin B; Cathepsin D; Defero | 2014 |
Deferoxamine attenuates acute hydrocephalus after traumatic brain injury in rats.
Topics: Acute Disease; Animals; Brain; Brain Injuries; Deferoxamine; Hydrocephalus; Iron; Lateral Ventricles | 2014 |
Acute Brain Injury after Subarachnoid Hemorrhage.
Topics: Acute Disease; Acute-Phase Proteins; Animals; Brain Injuries; Brain Ischemia; Deferoxamine; Hemoglob | 2015 |
Effects of deferoxamine on blood-brain barrier disruption after subarachnoid hemorrhage.
Topics: Animals; Behavior, Animal; Blood-Brain Barrier; Brain Edema; Brain Injuries; Cognition; Deferoxamine | 2017 |
Heme oxygenase-1 contributes to pathology associated with thrombin-induced striatal and cortical injury in organotypic slice culture.
Topics: Animals; Animals, Newborn; Astrocytes; Brain Injuries; Cerebral Cortex; Corpus Striatum; Deferoxamin | 2010 |
Role of iron in brain injury after intraventricular hemorrhage.
Topics: Animals; Brain Injuries; Cerebral Hemorrhage; Deferoxamine; Hippocampus; Iron; Lateral Ventricles; M | 2011 |
Deferoxamine reduces early brain injury following subarachnoid hemorrhage.
Topics: Analysis of Variance; Animals; Brain; Brain Injuries; Deferoxamine; Disease Models, Animal; DNA Dama | 2011 |
Deferoxamine attenuates iron-induced long-term neurotoxicity in rats with traumatic brain injury.
Topics: Analysis of Variance; Animals; Apoferritins; Atrophy; Brain; Brain Injuries; Deferoxamine; Disease M | 2013 |
Proposed toxic oxidant inhibitors fail to reduce brain edema.
Topics: Allopurinol; Animals; Brain Edema; Brain Injuries; Calcium; Cats; Cerebral Cortex; Cerebral Infarcti | 1994 |
Deferoxamine improves spatial memory performance following experimental brain injury in rats.
Topics: Animals; Brain Injuries; Cell Size; Deferoxamine; Hippocampus; Maze Learning; Memory; Motor Activity | 1996 |
Hemoglobin potentiates excitotoxic injury in cortical cell culture.
Topics: Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Antioxid | 1996 |
Effect of hypothermia, dichloroacetate, and deferoxamine in the treatment for cortical edema and functional recovery after experimental cortical impact in the rat.
Topics: Animals; Brain Edema; Brain Injuries; Deferoxamine; Dichloroacetic Acid; Hypothermia, Induced; Male; | 1997 |
Apparent role of hydroxyl radicals in oxidative brain injury induced by sodium nitroprusside.
Topics: Animals; Ascorbic Acid; Brain Injuries; Deferoxamine; Hydrogen Peroxide; Hydroxyl Radical; In Vitro | 1998 |
Astrocytes generate isoprostanes in response to trauma or oxygen radicals.
Topics: Animals; Astrocytes; Brain; Brain Injuries; Cells, Cultured; Cerebral Arteries; Cerebrovascular Circ | 2000 |
Endothelium-dependent responses after experimental brain injury.
Topics: Acetylcholine; Animals; Brain Injuries; Catalase; Cats; Cerebrovascular Circulation; Deferoxamine; E | 1992 |
Comparative effects of direct and indirect hydroxyl radical scavengers on traumatic brain oedema.
Topics: Animals; Body Water; Brain; Brain Edema; Brain Injuries; Cats; Deferoxamine; Dimethyl Sulfoxide; Fre | 1990 |