deferiprone has been researched along with Renal Insufficiency in 3 studies
Deferiprone: A pyridone derivative and iron chelator that is used in the treatment of IRON OVERLOAD in patients with THALASSEMIA.
deferiprone : A member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia.
Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " All subjects received a single oral dose of 33 mg kg(-1) DFP, provided serum and urine samples for pharmacokinetic assessment over 24 h and were monitored for safety." | 2.82 | Effects of renal impairment on the pharmacokinetics of orally administered deferiprone. ( Fradette, C; Jayashankar, S; Pichette, V; Sicard, É; Spino, M; Stilman, A; Tricta, F; Tsang, YC, 2016) |
| " A population pharmacokinetic analysis was performed using nonmem v." | 1.40 | Population pharmacokinetics of deferiprone in healthy subjects. ( Bellanti, F; Danhof, M; Della Pasqua, O, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Makhdoumi, P | 1 |
| Abnous, K | 1 |
| Mehri, S | 1 |
| Etemad, L | 1 |
| Imenshahidi, M | 1 |
| Karimi, G | 1 |
| Bellanti, F | 1 |
| Danhof, M | 1 |
| Della Pasqua, O | 1 |
| Fradette, C | 1 |
| Pichette, V | 1 |
| Sicard, É | 1 |
| Stilman, A | 1 |
| Jayashankar, S | 1 |
| Tsang, YC | 1 |
| Spino, M | 1 |
| Tricta, F | 1 |
1 trial available for deferiprone and Renal Insufficiency
| Article | Year |
|---|---|
Effects of renal impairment on the pharmacokinetics of orally administered deferiprone.
Topics: Administration, Oral; Adult; Aged; Deferiprone; Female; Glomerular Filtration Rate; Humans; Iron Che | 2016 |
2 other studies available for deferiprone and Renal Insufficiency
| Article | Year |
|---|---|
Oral deferiprone administration ameliorates cisplatin-induced nephrotoxicity in rats.
Topics: Aconitate Hydratase; Administration, Oral; Animals; Blood Urea Nitrogen; Cisplatin; Creatinine; Defe | 2018 |
Population pharmacokinetics of deferiprone in healthy subjects.
Topics: Adult; Area Under Curve; Creatinine; Deferiprone; Female; Humans; Male; Metabolic Clearance Rate; Mo | 2014 |