deferiprone has been researched along with Neuroblastoma in 3 studies
Deferiprone: A pyridone derivative and iron chelator that is used in the treatment of IRON OVERLOAD in patients with THALASSEMIA.
deferiprone : A member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The iron chelator, deferoxamine, has demonstrated cytotoxicity against neuroblastoma cells." | 7.67 | Comparison of activity of deferoxamine with that of oral iron chelators against human neuroblastoma cell lines. ( Blatt, J; Kontoghiorghes, GJ; Taylor, SR, 1989) |
| "The iron chelator, deferoxamine, has demonstrated cytotoxicity against neuroblastoma cells." | 3.67 | Comparison of activity of deferoxamine with that of oral iron chelators against human neuroblastoma cell lines. ( Blatt, J; Kontoghiorghes, GJ; Taylor, SR, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Tong, ZB | 1 |
| Kim, H | 1 |
| El Touny, L | 1 |
| Simeonov, A | 1 |
| Gerhold, D | 1 |
| Selig, RA | 1 |
| White, L | 1 |
| Gramacho, C | 1 |
| Sterling-Levis, K | 1 |
| Fraser, IW | 1 |
| Naidoo, D | 1 |
| Blatt, J | 1 |
| Taylor, SR | 1 |
| Kontoghiorghes, GJ | 1 |
3 other studies available for deferiprone and Neuroblastoma
| Article | Year |
|---|---|
LUHMES Dopaminergic Neurons Are Uniquely Susceptible to Ferroptosis.
Topics: Carbolines; Chelating Agents; Deferiprone; Dopaminergic Neurons; Ferroptosis; Glutathione; Humans; I | 2022 |
Failure of iron chelators to reduce tumor growth in human neuroblastoma xenografts.
Topics: Administration, Oral; Animals; Child, Preschool; Deferiprone; Deferoxamine; Drug Delivery Systems; D | 1998 |
Comparison of activity of deferoxamine with that of oral iron chelators against human neuroblastoma cell lines.
Topics: Administration, Oral; Cell Cycle; Cell Survival; Deferiprone; Deferoxamine; Humans; Hydroxybenzoates | 1989 |