deferiprone has been researched along with Cirrhosis, Liver in 20 studies
Deferiprone: A pyridone derivative and iron chelator that is used in the treatment of IRON OVERLOAD in patients with THALASSEMIA.
deferiprone : A member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia.
Excerpt | Relevance | Reference |
---|---|---|
"The role of the orally active iron (Fe) chelator deferiprone in the treatment of beta-thalassemia remains a controversial subject." | 8.81 | The controversial role of deferiprone in the treatment of thalassemia. ( Richardson, DR, 2001) |
"Patients with thalassemia major require lifelong chelation therapy to prevent iron-induced organ damage." | 6.70 | Lack of progressive hepatic fibrosis during long-term therapy with deferiprone in subjects with transfusion-dependent beta-thalassemia. ( Cohen, AR; Dhillon, AP; Galanello, R; Gamberini, MR; Guido, M; Piga, A; Schwartz, E; Sweeney, G; Wanless, IR, 2002) |
"Deferiprone is an orally active iron-chelating agent that is being evaluated as a treatment for iron overload in thalassemia major." | 5.08 | Long-term safety and effectiveness of iron-chelation therapy with deferiprone for thalassemia major. ( Brittenham, GM; Burt, AD; Cameron, RG; Fleming, KA; McClelland, RA; McLaren, CE; Olivieri, NF; Templeton, DM, 1998) |
"The role of the orally active iron (Fe) chelator deferiprone in the treatment of beta-thalassemia remains a controversial subject." | 4.81 | The controversial role of deferiprone in the treatment of thalassemia. ( Richardson, DR, 2001) |
"Deferiprone (L1) is an orally active iron-chelation agent that is being evaluated as a treatment for iron overload in thalassemia major." | 3.73 | Liver fibrosis and iron levels during long-term deferiprone treatment of thalassemia major patients. ( Peng, CT; Tsai, CH; Wu, KH; Wu, SF, 2006) |
"Patients with thalassemia major require lifelong chelation therapy to prevent iron-induced organ damage." | 2.70 | Lack of progressive hepatic fibrosis during long-term therapy with deferiprone in subjects with transfusion-dependent beta-thalassemia. ( Cohen, AR; Dhillon, AP; Galanello, R; Gamberini, MR; Guido, M; Piga, A; Schwartz, E; Sweeney, G; Wanless, IR, 2002) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 8 (40.00) | 18.2507 |
2000's | 11 (55.00) | 29.6817 |
2010's | 1 (5.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Dessì, C | 1 |
Leoni, G | 1 |
Moi, P | 1 |
Danjou, F | 1 |
Follesa, I | 1 |
Foschini, ML | 1 |
Morittu, M | 1 |
Zappu, A | 1 |
Defraia, E | 1 |
Bina, P | 1 |
Cunico, A | 1 |
Civolani, A | 1 |
Podda, RA | 1 |
Origa, R | 1 |
Wanless, IR | 1 |
Sweeney, G | 1 |
Dhillon, AP | 1 |
Guido, M | 1 |
Piga, A | 2 |
Galanello, R | 1 |
Gamberini, MR | 1 |
Schwartz, E | 1 |
Cohen, AR | 1 |
Brittenham, GM | 2 |
Nathan, DG | 2 |
Olivieri, NF | 2 |
Porter, JB | 1 |
Pippard, M | 1 |
Vichinsky, EP | 1 |
Weatherall, DJ | 3 |
Downie, J | 1 |
Baird, P | 1 |
Thompson, J | 1 |
Viens, AM | 1 |
Savulescu, J | 1 |
Roggero, S | 1 |
Vinciguerra, T | 1 |
Sacchetti, L | 1 |
Gallo, V | 1 |
Longo, F | 1 |
Meo, A | 1 |
Ruggeri, A | 1 |
La Rosa, MA | 1 |
Zanghì, L | 1 |
Morabito, N | 1 |
Duca, L | 1 |
Chen, AC | 1 |
Peng, CT | 2 |
Wu, SF | 2 |
Wu, KH | 2 |
Chiang, IP | 1 |
Tsai, CH | 2 |
Töndury, P | 2 |
Zimmermann, A | 1 |
Nielsen, P | 1 |
Hirt, A | 1 |
McLaren, CE | 1 |
Templeton, DM | 1 |
Cameron, RG | 1 |
McClelland, RA | 1 |
Burt, AD | 1 |
Fleming, KA | 1 |
Kowdley, KV | 1 |
Kaplan, MM | 1 |
Tricta, F | 1 |
Spino, M | 1 |
Callea, F | 1 |
Stella, M | 1 |
Pinzello, G | 1 |
Maggio, A | 1 |
Wonke, B | 1 |
Telfer, P | 1 |
Hoffbrand, AV | 1 |
Pippard, MJ | 1 |
Kontoghiorghes, GJ | 1 |
Agarwal, MB | 1 |
Marx, JJ | 1 |
Richardson, DR | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Retrospective and Prospective Multicenter Study Using Deferiprone (L1) Alone or in Combination With Desferrioxamine for the Treatment of Iron Overload in Transfusion-dependent Patients[NCT00349453] | Phase 2 | 24 participants (Actual) | Interventional | 2005-03-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
3 reviews available for deferiprone and Cirrhosis, Liver
Article | Year |
---|---|
Deferiprone: New insight.
Topics: Agranulocytosis; Cardiomyopathies; Clinical Trials as Topic; Deferiprone; Deferoxamine; Follow-Up St | 2005 |
Oral iron chelation therapy for thalassaemia: an uncertain scene.
Topics: beta-Thalassemia; Chelation Therapy; Deferiprone; Deferoxamine; Humans; Iron Chelating Agents; Iron | 2000 |
The controversial role of deferiprone in the treatment of thalassemia.
Topics: Agranulocytosis; Arthralgia; Clinical Trials as Topic; Deferiprone; Deferoxamine; Drug Therapy, Comb | 2001 |
2 trials available for deferiprone and Cirrhosis, Liver
Article | Year |
---|---|
Lack of progressive hepatic fibrosis during long-term therapy with deferiprone in subjects with transfusion-dependent beta-thalassemia.
Topics: Adolescent; Adult; beta-Thalassemia; Biopsy; Blood Transfusion; Child; Deferiprone; Female; Humans; | 2002 |
Long-term safety and effectiveness of iron-chelation therapy with deferiprone for thalassemia major.
Topics: Adolescent; Adult; beta-Thalassemia; Biopsy; Child; Deferiprone; Deferoxamine; Disease Progression; | 1998 |
15 other studies available for deferiprone and Cirrhosis, Liver
Article | Year |
---|---|
Thalassemia major between liver and heart: Where we are now.
Topics: Adolescent; Adult; beta-Thalassemia; Child; Child, Preschool; Cohort Studies; Deferiprone; Deferoxam | 2015 |
Deferiprone and hepatic fibrosis.
Topics: Deferiprone; Humans; Iron Overload; Liver Cirrhosis; Pyridones | 2003 |
Industry and the academy: conflicts of interest in contemporary health research.
Topics: Biomedical Research; Clinical Trials as Topic; Conflict of Interest; Deferiprone; Drug Industry; Hos | 2002 |
Introduction to The Olivieri symposium.
Topics: beta-Thalassemia; Bioethical Issues; Blood Transfusion; Canada; Clinical Trials as Topic; Deferipron | 2004 |
Iron burden and liver fibrosis decrease during a long-term phlebotomy program and iron chelating treatment after bone marrow transplantation.
Topics: Adolescent; Anemia, Sideroblastic; Biomarkers; Bone Marrow Transplantation; Chelation Therapy; Combi | 2006 |
Effect of deferiprone on liver iron overload and fibrosis in hepatitis-C-virus-infected thalassemia.
Topics: Adolescent; Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Chelatio | 2006 |
Liver fibrosis and iron levels during long-term deferiprone treatment of thalassemia major patients.
Topics: Adolescent; Adult; Alanine Transaminase; beta-Thalassemia; Biomarkers; Biopsy; Chelation Therapy; Ch | 2006 |
Liver iron and fibrosis during long-term treatment with deferiprone in Swiss thalassaemic patients.
Topics: Adolescent; Adult; beta-Thalassemia; Chronic Disease; Deferiprone; Ferritins; Hepatitis C; Humans; I | 1998 |
Iron-chelation therapy with oral deferiprone--toxicity or lack of efficacy?
Topics: Administration, Oral; beta-Thalassemia; Biopsy; Deferiprone; Humans; Iron; Iron Overload; Liver; Liv | 1998 |
Iron chelation with oral deferiprone in patients with thalassemia.
Topics: beta-Thalassemia; Biopsy; Deferiprone; Humans; Iron Chelating Agents; Iron Overload; Liver Cirrhosis | 1998 |
Iron chelation with oral deferiprone in patients with thalassemia.
Topics: beta-Thalassemia; Biopsy; Deferiprone; Humans; Iron Chelating Agents; Iron Overload; Liver; Liver Ci | 1998 |
Iron chelation with oral deferiprone in patients with thalassemia.
Topics: beta-Thalassemia; Biopsy; Deferiprone; Humans; Iron Chelating Agents; Iron Overload; Liver; Liver Ci | 1998 |
Iron chelation with oral deferiprone in patients with thalassemia.
Topics: beta-Thalassemia; Biopsy; Deferiprone; Deferoxamine; Ferritins; Humans; Iron Chelating Agents; Iron | 1998 |
Iron chelation with oral deferiprone in patients with thalassemia.
Topics: beta-Thalassemia; Deferiprone; Humans; Iron; Iron Chelating Agents; Iron Overload; Liver; Liver Cirr | 1998 |
Deferiprone or fatal iron toxic effects?
Topics: Deferiprone; Humans; Iron Chelating Agents; Liver Cirrhosis; Pyridones; Thalassemia | 2001 |