Page last updated: 2024-10-25

deferiprone and Cirrhosis, Liver

deferiprone has been researched along with Cirrhosis, Liver in 20 studies

Deferiprone: A pyridone derivative and iron chelator that is used in the treatment of IRON OVERLOAD in patients with THALASSEMIA.
deferiprone : A member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia.

Research Excerpts

ExcerptRelevanceReference
"The role of the orally active iron (Fe) chelator deferiprone in the treatment of beta-thalassemia remains a controversial subject."8.81The controversial role of deferiprone in the treatment of thalassemia. ( Richardson, DR, 2001)
"Patients with thalassemia major require lifelong chelation therapy to prevent iron-induced organ damage."6.70Lack of progressive hepatic fibrosis during long-term therapy with deferiprone in subjects with transfusion-dependent beta-thalassemia. ( Cohen, AR; Dhillon, AP; Galanello, R; Gamberini, MR; Guido, M; Piga, A; Schwartz, E; Sweeney, G; Wanless, IR, 2002)
"Deferiprone is an orally active iron-chelating agent that is being evaluated as a treatment for iron overload in thalassemia major."5.08Long-term safety and effectiveness of iron-chelation therapy with deferiprone for thalassemia major. ( Brittenham, GM; Burt, AD; Cameron, RG; Fleming, KA; McClelland, RA; McLaren, CE; Olivieri, NF; Templeton, DM, 1998)
"The role of the orally active iron (Fe) chelator deferiprone in the treatment of beta-thalassemia remains a controversial subject."4.81The controversial role of deferiprone in the treatment of thalassemia. ( Richardson, DR, 2001)
"Deferiprone (L1) is an orally active iron-chelation agent that is being evaluated as a treatment for iron overload in thalassemia major."3.73Liver fibrosis and iron levels during long-term deferiprone treatment of thalassemia major patients. ( Peng, CT; Tsai, CH; Wu, KH; Wu, SF, 2006)
"Patients with thalassemia major require lifelong chelation therapy to prevent iron-induced organ damage."2.70Lack of progressive hepatic fibrosis during long-term therapy with deferiprone in subjects with transfusion-dependent beta-thalassemia. ( Cohen, AR; Dhillon, AP; Galanello, R; Gamberini, MR; Guido, M; Piga, A; Schwartz, E; Sweeney, G; Wanless, IR, 2002)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (40.00)18.2507
2000's11 (55.00)29.6817
2010's1 (5.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dessì, C1
Leoni, G1
Moi, P1
Danjou, F1
Follesa, I1
Foschini, ML1
Morittu, M1
Zappu, A1
Defraia, E1
Bina, P1
Cunico, A1
Civolani, A1
Podda, RA1
Origa, R1
Wanless, IR1
Sweeney, G1
Dhillon, AP1
Guido, M1
Piga, A2
Galanello, R1
Gamberini, MR1
Schwartz, E1
Cohen, AR1
Brittenham, GM2
Nathan, DG2
Olivieri, NF2
Porter, JB1
Pippard, M1
Vichinsky, EP1
Weatherall, DJ3
Downie, J1
Baird, P1
Thompson, J1
Viens, AM1
Savulescu, J1
Roggero, S1
Vinciguerra, T1
Sacchetti, L1
Gallo, V1
Longo, F1
Meo, A1
Ruggeri, A1
La Rosa, MA1
Zanghì, L1
Morabito, N1
Duca, L1
Chen, AC1
Peng, CT2
Wu, SF2
Wu, KH2
Chiang, IP1
Tsai, CH2
Töndury, P2
Zimmermann, A1
Nielsen, P1
Hirt, A1
McLaren, CE1
Templeton, DM1
Cameron, RG1
McClelland, RA1
Burt, AD1
Fleming, KA1
Kowdley, KV1
Kaplan, MM1
Tricta, F1
Spino, M1
Callea, F1
Stella, M1
Pinzello, G1
Maggio, A1
Wonke, B1
Telfer, P1
Hoffbrand, AV1
Pippard, MJ1
Kontoghiorghes, GJ1
Agarwal, MB1
Marx, JJ1
Richardson, DR1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Retrospective and Prospective Multicenter Study Using Deferiprone (L1) Alone or in Combination With Desferrioxamine for the Treatment of Iron Overload in Transfusion-dependent Patients[NCT00349453]Phase 224 participants (Actual)Interventional2005-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for deferiprone and Cirrhosis, Liver

ArticleYear
Deferiprone: New insight.
    Annals of the New York Academy of Sciences, 2005, Volume: 1054

    Topics: Agranulocytosis; Cardiomyopathies; Clinical Trials as Topic; Deferiprone; Deferoxamine; Follow-Up St

2005
Oral iron chelation therapy for thalassaemia: an uncertain scene.
    British journal of haematology, 2000, Volume: 111, Issue:1

    Topics: beta-Thalassemia; Chelation Therapy; Deferiprone; Deferoxamine; Humans; Iron Chelating Agents; Iron

2000
The controversial role of deferiprone in the treatment of thalassemia.
    The Journal of laboratory and clinical medicine, 2001, Volume: 137, Issue:5

    Topics: Agranulocytosis; Arthralgia; Clinical Trials as Topic; Deferiprone; Deferoxamine; Drug Therapy, Comb

2001

Trials

2 trials available for deferiprone and Cirrhosis, Liver

ArticleYear
Lack of progressive hepatic fibrosis during long-term therapy with deferiprone in subjects with transfusion-dependent beta-thalassemia.
    Blood, 2002, Sep-01, Volume: 100, Issue:5

    Topics: Adolescent; Adult; beta-Thalassemia; Biopsy; Blood Transfusion; Child; Deferiprone; Female; Humans;

2002
Long-term safety and effectiveness of iron-chelation therapy with deferiprone for thalassemia major.
    The New England journal of medicine, 1998, Aug-13, Volume: 339, Issue:7

    Topics: Adolescent; Adult; beta-Thalassemia; Biopsy; Child; Deferiprone; Deferoxamine; Disease Progression;

1998

Other Studies

15 other studies available for deferiprone and Cirrhosis, Liver

ArticleYear
Thalassemia major between liver and heart: Where we are now.
    Blood cells, molecules & diseases, 2015, Volume: 55, Issue:1

    Topics: Adolescent; Adult; beta-Thalassemia; Child; Child, Preschool; Cohort Studies; Deferiprone; Deferoxam

2015
Deferiprone and hepatic fibrosis.
    Blood, 2003, Jun-15, Volume: 101, Issue:12

    Topics: Deferiprone; Humans; Iron Overload; Liver Cirrhosis; Pyridones

2003
Industry and the academy: conflicts of interest in contemporary health research.
    Health law journal, 2002, Volume: 10

    Topics: Biomedical Research; Clinical Trials as Topic; Conflict of Interest; Deferiprone; Drug Industry; Hos

2002
Introduction to The Olivieri symposium.
    Journal of medical ethics, 2004, Volume: 30, Issue:1

    Topics: beta-Thalassemia; Bioethical Issues; Blood Transfusion; Canada; Clinical Trials as Topic; Deferipron

2004
Iron burden and liver fibrosis decrease during a long-term phlebotomy program and iron chelating treatment after bone marrow transplantation.
    Hemoglobin, 2006, Volume: 30, Issue:1

    Topics: Adolescent; Anemia, Sideroblastic; Biomarkers; Bone Marrow Transplantation; Chelation Therapy; Combi

2006
Effect of deferiprone on liver iron overload and fibrosis in hepatitis-C-virus-infected thalassemia.
    Hemoglobin, 2006, Volume: 30, Issue:2

    Topics: Adolescent; Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Chelatio

2006
Liver fibrosis and iron levels during long-term deferiprone treatment of thalassemia major patients.
    Hemoglobin, 2006, Volume: 30, Issue:2

    Topics: Adolescent; Adult; Alanine Transaminase; beta-Thalassemia; Biomarkers; Biopsy; Chelation Therapy; Ch

2006
Liver iron and fibrosis during long-term treatment with deferiprone in Swiss thalassaemic patients.
    British journal of haematology, 1998, Volume: 101, Issue:3

    Topics: Adolescent; Adult; beta-Thalassemia; Chronic Disease; Deferiprone; Ferritins; Hepatitis C; Humans; I

1998
Iron-chelation therapy with oral deferiprone--toxicity or lack of efficacy?
    The New England journal of medicine, 1998, Aug-13, Volume: 339, Issue:7

    Topics: Administration, Oral; beta-Thalassemia; Biopsy; Deferiprone; Humans; Iron; Iron Overload; Liver; Liv

1998
Iron chelation with oral deferiprone in patients with thalassemia.
    The New England journal of medicine, 1998, Dec-03, Volume: 339, Issue:23

    Topics: beta-Thalassemia; Biopsy; Deferiprone; Humans; Iron Chelating Agents; Iron Overload; Liver Cirrhosis

1998
Iron chelation with oral deferiprone in patients with thalassemia.
    The New England journal of medicine, 1998, Dec-03, Volume: 339, Issue:23

    Topics: beta-Thalassemia; Biopsy; Deferiprone; Humans; Iron Chelating Agents; Iron Overload; Liver; Liver Ci

1998
Iron chelation with oral deferiprone in patients with thalassemia.
    The New England journal of medicine, 1998, Dec-03, Volume: 339, Issue:23

    Topics: beta-Thalassemia; Biopsy; Deferiprone; Humans; Iron Chelating Agents; Iron Overload; Liver; Liver Ci

1998
Iron chelation with oral deferiprone in patients with thalassemia.
    The New England journal of medicine, 1998, Dec-03, Volume: 339, Issue:23

    Topics: beta-Thalassemia; Biopsy; Deferiprone; Deferoxamine; Ferritins; Humans; Iron Chelating Agents; Iron

1998
Iron chelation with oral deferiprone in patients with thalassemia.
    The New England journal of medicine, 1998, Dec-03, Volume: 339, Issue:23

    Topics: beta-Thalassemia; Deferiprone; Humans; Iron; Iron Chelating Agents; Iron Overload; Liver; Liver Cirr

1998
Deferiprone or fatal iron toxic effects?
    Lancet (London, England), 2001, Mar-17, Volume: 357, Issue:9259

    Topics: Deferiprone; Humans; Iron Chelating Agents; Liver Cirrhosis; Pyridones; Thalassemia

2001