deferiprone has been researched along with Carcinoma, Hepatocellular in 4 studies
Deferiprone: A pyridone derivative and iron chelator that is used in the treatment of IRON OVERLOAD in patients with THALASSEMIA.
deferiprone : A member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hepatic non-transferrin-bound Fe (NTBI) flux and its regulation were characterized by measuring the uptake of Fe from [59Fe]/nitrilotriacetate (NTA) complexes in control and Fe-loaded cultures of human hepatocellular carcinoma cells (HepG2)." | 3.69 | Modulation by iron loading and chelation of the uptake of non-transferrin-bound iron by human liver cells. ( Olivieri, NF; Parkes, JG; Randell, EW; Templeton, DM, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gaboriau, F | 3 |
| Leray, AM | 1 |
| Ropert, M | 1 |
| Gouffier, L | 1 |
| Cannie, I | 1 |
| Troadec, MB | 1 |
| Loréal, O | 1 |
| Brissot, P | 3 |
| Lescoat, G | 3 |
| Chantrel-Groussard, K | 2 |
| Rakba, N | 1 |
| Loyer, P | 1 |
| Pasdeloup, N | 2 |
| Hider, RC | 1 |
| Nick, H | 1 |
| Parkes, JG | 1 |
| Randell, EW | 1 |
| Olivieri, NF | 1 |
| Templeton, DM | 1 |
4 other studies available for deferiprone and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Effects of deferasirox and deferiprone on cellular iron load in the human hepatoma cell line HepaRG.
Topics: Benzoates; Carcinoma, Hepatocellular; Cell Line, Tumor; Deferasirox; Deferiprone; Dose-Response Rela | 2010 |
Iron mobilization, cytoprotection, and inhibition of cell proliferation in normal and transformed rat hepatocyte cultures by the hydroxypyridinone CP411, compared to CP20: a biological and physicochemical study.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Division; Cells, Cultured; Cytoprote | 2004 |
Antiproliferative and apoptotic effects in rat and human hepatoma cell cultures of the orally active iron chelator ICL670 compared to CP20: a possible relationship with polyamine metabolism.
Topics: Animals; Apoptosis; Base Sequence; Benzoates; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumo | 2007 |
Modulation by iron loading and chelation of the uptake of non-transferrin-bound iron by human liver cells.
Topics: Biological Transport; Carcinoma, Hepatocellular; Cell Death; Deferiprone; Deferoxamine; Diffusion; F | 1995 |