deferiprone has been researched along with Bronze Diabetes in 12 studies
Deferiprone: A pyridone derivative and iron chelator that is used in the treatment of IRON OVERLOAD in patients with THALASSEMIA.
deferiprone : A member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Deferiprone (L1), and appropriate combinations with deferoxamine (DFO), can be used effectively for the treatment of thalassemia and other transfusional iron loading conditions." | 8.83 | Future chelation monotherapy and combination therapy strategies in thalassemia and other conditions. comparison of deferiprone, deferoxamine, ICL670, GT56-252, L1NAll and starch deferoxamine polymers. ( Kontoghiorghes, GJ, 2006) |
| "Deferiprone (L1), and appropriate combinations with deferoxamine (DFO), can be used effectively for the treatment of thalassemia and other transfusional iron loading conditions." | 4.83 | Future chelation monotherapy and combination therapy strategies in thalassemia and other conditions. comparison of deferiprone, deferoxamine, ICL670, GT56-252, L1NAll and starch deferoxamine polymers. ( Kontoghiorghes, GJ, 2006) |
| "Iron overload is characterized by excessive iron deposition and consequent injury and dysfunction of the heart, liver, anterior pituitary, pancreas, and joints." | 2.44 | Chelation therapy for iron overload. ( Barton, JC, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 4 (33.33) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Feng, W | 1 |
| Xiao, Y | 1 |
| Zhao, C | 1 |
| Zhang, Z | 1 |
| Liu, W | 1 |
| Ma, J | 1 |
| Ganz, T | 1 |
| Zhang, J | 1 |
| Liu, S | 1 |
| Lee, JA | 1 |
| Tchantchaleishvili, V | 1 |
| Vidula, H | 1 |
| Nijjar, PS | 1 |
| Vongooru, H | 1 |
| Tamene, A | 1 |
| Valeti, U | 1 |
| Masri, C | 1 |
| Tauchenová, L | 1 |
| Křížová, B | 1 |
| Kubánek, M | 1 |
| Fraňková, S | 1 |
| Melenovský, V | 1 |
| Tintěra, J | 1 |
| Kautznerová, D | 1 |
| Malušková, J | 1 |
| Jirsa, M | 1 |
| Kautzner, J | 1 |
| Kontoghiorghes, GJ | 3 |
| Eracleous, E | 1 |
| Economides, C | 1 |
| Kolnagou, A | 1 |
| Fabio, G | 1 |
| Minonzio, F | 1 |
| Delbini, P | 1 |
| Bianchi, A | 1 |
| Cappellini, MD | 1 |
| Barton, JC | 1 |
| Florence, A | 1 |
| Ward, RJ | 1 |
| Peters, TJ | 1 |
| Crichton, RR | 1 |
| Chandy, M | 1 |
| Agarwal, MB | 1 |
| Gupte, SS | 1 |
| Vasandani, D | 1 |
| Viswanathan, C | 1 |
| Puniyani, RR | 1 |
| Ramanathan, J | 1 |
| Massil, DE | 1 |
| Shah, S | 1 |
| Rajyadhyaksha, GC | 1 |
| Bhave, AA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Trial of Oral Nifedipine for the Treatment of Iron Overload[NCT00712738] | Phase 1 | 6 participants (Actual) | Interventional | 2008-06-20 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for deferiprone and Bronze Diabetes
| Article | Year |
|---|---|
Advances in iron overload therapies. prospects for effective use of deferiprone (L1), deferoxamine, the new experimental chelators ICL670, GT56-252, L1NA11 and their combinations.
Topics: Benzoates; Carboxylic Acids; Deferasirox; Deferiprone; Deferoxamine; Drug Therapy, Combination; Hemo | 2005 |
Future chelation monotherapy and combination therapy strategies in thalassemia and other conditions. comparison of deferiprone, deferoxamine, ICL670, GT56-252, L1NAll and starch deferoxamine polymers.
Topics: Benzoates; Carboxylic Acids; Chelation Therapy; Clinical Trials as Topic; Deferasirox; Deferiprone; | 2006 |
Chelation therapy for iron overload.
Topics: Anemia; Anemia, Sickle Cell; Benzoates; beta-Thalassemia; Chelation Therapy; Deferasirox; Deferipron | 2007 |
1 trial available for deferiprone and Bronze Diabetes
| Article | Year |
|---|---|
Efficacy and safety of 1-2, dimethyl-3-hydroxypyrid-4-one (L1) as an oral iron chelator in patients of beta thalassaemia major with iron overload.
Topics: Adolescent; Chelation Therapy; Deferiprone; Hemochromatosis; Humans; Iron Chelating Agents; Pyridone | 1991 |
8 other studies available for deferiprone and Bronze Diabetes
| Article | Year |
|---|---|
New Deferric Amine Compounds Efficiently Chelate Excess Iron to Treat Iron Overload Disorders and to Prevent Ferroptosis.
Topics: Amines; Animals; Deferiprone; Deferoxamine; Dextrans; Ferroptosis; Hemochromatosis; Humans; Iron; Ir | 2022 |
Cardiac Hemochromatosis Treated With Prolonged Extracorporeal Membrane Oxygenation Support and Chelation Therapy.
Topics: Adult; Cardiomyopathies; Chelation Therapy; Deferasirox; Deferiprone; Deferoxamine; Extracorporeal M | 2018 |
Improvement in Left Ventricular Function Despite No Change in T2* with Iron Chelation in Secondary Hemochromatosis.
Topics: Adult; Anemia, Aplastic; Deferiprone; Deferoxamine; Echocardiography; Hemochromatosis; Humans; Iron | 2015 |
Successful Treatment of Iron-Overload Cardiomyopathy in Hereditary Hemochromatosis With Deferoxamine and Deferiprone.
Topics: Cardiomyopathies; Deferiprone; Deferoxamine; Ferritins; Heart Failure; Hemochromatosis; Hemochromato | 2016 |
Reversal of cardiac complications by deferiprone and deferoxamine combination therapy in a patient affected by a severe type of juvenile hemochromatosis (JH).
Topics: Adult; Amino Acid Substitution; Antimicrobial Cationic Peptides; Atrial Fibrillation; Chelation Ther | 2007 |
Studies of in vivo iron mobilization by chelators in the ferrocene-loaded rat.
Topics: Animals; Brain; Deferiprone; Deferoxamine; Disease Models, Animal; Ferrous Compounds; Heart; Hemochr | 1992 |
Oral iron chelation is here.
Topics: Administration, Oral; Deferiprone; Hemochromatosis; Humans; Iron Chelating Agents; Pyridones | 1991 |
Iron chelation.
Topics: Chelation Therapy; Deferiprone; Deferoxamine; Hemochromatosis; Humans; Iron; Iron Chelating Agents; | 1991 |