deet has been researched along with Disease Models, Animal in 19 studies
N,N-diethyl-m-toluamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of m-toluic acid with the nitrogen of diethylamine. First developed by the U.S. Army in 1946 for use by military personnel in insect-infested areas, it is the most widely used insect repellent worldwide.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We used a mouse model of GWI by exposing mice repeatedly to a combination of Gulf War chemicals (pyridostigmine bromide, permethrin, DEET, and chlorpyrifos) and mild immobilization stress, followed by investigating their pain susceptibilities and fatigue symptoms." | 4.02 | Exposure to Gulf War Illness-related agents leads to the development of chronic pain and fatigue. ( Clark, JD; Goba, L; Huang, TT; Nguyen, H; Sahbaie, P; Sul, J; Suzaki, A, 2021) |
| "We investigated whether brain inflammation in GWI is associated with activation of high mobility group box-1 (HMGB1) and complement-related proteins in neurons and astrocytes, and brain inflammation can be tracked through neuron-derived extracellular vesicles (NDEVs) and astrocyte-derived EVs (ADEVs) found in the circulating blood." | 1.51 | Neuroinflammation in Gulf War Illness is linked with HMGB1 and complement activation, which can be discerned from brain-derived extracellular vesicles in the blood. ( Attaluri, S; Gitai, D; Kodali, M; Madhu, LN; Shetty, AK; Shuai, B; Upadhya, R, 2019) |
| "DEET was highly effective in preventing penetration of cercariae as well as its further migration to liver which is proved histopathologically in the liver." | 1.30 | The potential use of N,N-diethyl-m-toluamide (DEET) as a prophylactic agent in the control of schistosomiasis. ( Twfeek, GM, 1999) |
| " Both the extent and rate of absorption in monkeys were highly dependent on anatomic site, with 14 +/- 5% (t1/2 = 4 h) penetrating the forearm, 33 +/- 11% (t1/2 = 6 h) the forehead, 27 +/- 3% (t1/2 = 7 h) the dorsal forepaw, and 68 +/- 9% (t1/2 = 8 h) the ventral forepaw." | 1.28 | Dermal absorption of the insect repellent DEET (N,N-diethyl-m-toluamide) in rats and monkeys: effect of anatomical site and multiple exposure. ( Benoit, FM; Moody, RP; Riedel, D; Ritter, L, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.26) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 9 (47.37) | 24.3611 |
| 2020's | 3 (15.79) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Carpenter, JM | 1 |
| Gordon, HE | 1 |
| Ludwig, HD | 1 |
| Wagner, JJ | 1 |
| Harn, DA | 1 |
| Norberg, T | 1 |
| Filipov, NM | 1 |
| Nguyen, H | 1 |
| Sahbaie, P | 1 |
| Goba, L | 1 |
| Sul, J | 1 |
| Suzaki, A | 1 |
| Clark, JD | 1 |
| Huang, TT | 1 |
| Carreras, I | 1 |
| Aytan, N | 1 |
| Mellott, T | 1 |
| Choi, JK | 1 |
| Lehar, M | 1 |
| Crabtree, L | 1 |
| Leite-Morris, K | 1 |
| Jenkins, BG | 1 |
| Blusztajn, JK | 1 |
| Dedeoglu, A | 1 |
| Kodali, M | 2 |
| Hattiangady, B | 2 |
| Shetty, GA | 1 |
| Bates, A | 1 |
| Shuai, B | 3 |
| Shetty, AK | 3 |
| Cooper, BY | 2 |
| Flunker, LD | 1 |
| Johnson, RD | 2 |
| Nutter, TJ | 2 |
| Michalovicz, LT | 1 |
| Locker, AR | 2 |
| Kelly, KA | 2 |
| Miller, JV | 1 |
| Barnes, Z | 1 |
| Fletcher, MA | 1 |
| Miller, DB | 2 |
| Klimas, NG | 1 |
| Morris, M | 1 |
| Lasley, SM | 2 |
| O'Callaghan, JP | 2 |
| Madhu, LN | 1 |
| Attaluri, S | 1 |
| Upadhya, R | 1 |
| Gitai, D | 1 |
| Parihar, VK | 1 |
| Flunker, LK | 1 |
| Webb, CE | 1 |
| Russell, RC | 1 |
| Abdullah, L | 1 |
| Evans, JE | 1 |
| Bishop, A | 1 |
| Reed, JM | 1 |
| Crynen, G | 1 |
| Phillips, J | 1 |
| Pelot, R | 1 |
| Mullan, MA | 1 |
| Ferro, A | 1 |
| Mullan, CM | 1 |
| Mullan, MJ | 1 |
| Ait-Ghezala, G | 1 |
| Crawford, FC | 1 |
| Peden-Adam, MM | 1 |
| Eudaly, J | 1 |
| Eudaly, E | 1 |
| Dudley, A | 1 |
| Zeigler, J | 1 |
| Lee, A | 1 |
| Robbs, J | 1 |
| Gilkeson, G | 1 |
| Keil, DE | 1 |
| Twfeek, GM | 1 |
| Abdel-Rahman, A | 1 |
| Abou-Donia, S | 1 |
| El-Masry, E | 1 |
| Shetty, A | 1 |
| Abou-Donia, M | 1 |
| Garthwaite, G | 1 |
| Batchelor, AM | 1 |
| Goodwin, DA | 1 |
| Hewson, AK | 1 |
| Leeming, K | 1 |
| Ahmed, Z | 1 |
| Cuzner, ML | 1 |
| Garthwaite, J | 1 |
| Salafsky, B | 1 |
| Ramaswamy, K | 1 |
| He, YX | 1 |
| Anderson, GL | 1 |
| Nowicki, DK | 1 |
| Shibuya, T | 1 |
| Moody, RP | 1 |
| Benoit, FM | 1 |
| Riedel, D | 1 |
| Ritter, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-blind, Placebo-controlled Clinical Trial of Oleoylethanolamide (OEA) for Targeting Lipid Metabolism in Gulf War Illness[NCT05252949] | 52 participants (Anticipated) | Interventional | 2021-06-10 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
19 other studies available for deet and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Neurochemical and neuroinflammatory perturbations in two Gulf War Illness models: Modulation by the immunotherapeutic LNFPIII.
Topics: Amino Sugars; Animals; Biogenic Monoamines; Brain; Brain Chemistry; DEET; Disease Models, Animal; En | 2020 |
Exposure to Gulf War Illness-related agents leads to the development of chronic pain and fatigue.
Topics: Animals; Chlorpyrifos; Chronic Pain; DEET; Disease Models, Animal; Fatigue; Humans; Mice; Permethrin | 2021 |
Anxiety, neuroinflammation, cholinergic and GABAergic abnormalities are early markers of Gulf War illness in a mouse model of the disease.
Topics: Acetylcholine; Animals; Anxiety; Astrocytes; Brain; DEET; Disease Models, Animal; Encephalitis; Fema | 2018 |
Curcumin treatment leads to better cognitive and mood function in a model of Gulf War Illness with enhanced neurogenesis, and alleviation of inflammation and mitochondrial dysfunction in the hippocampus.
Topics: Affect; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cognition; Curcumin; DEET; Disease Models, | 2018 |
Behavioral, cellular and molecular maladaptations covary with exposure to pyridostigmine bromide in a rat model of gulf war illness pain.
Topics: Adaptation, Physiological; Animals; Behavior, Animal; Chlorpyrifos; DEET; Disease Models, Animal; Ga | 2018 |
Corticosterone and pyridostigmine/DEET exposure attenuate peripheral cytokine expression: Supporting a dominant role for neuroinflammation in a mouse model of Gulf War Illness.
Topics: Animals; Cholinesterase Inhibitors; Corticosterone; Cytokines; DEET; Disease Models, Animal; Gene Ex | 2019 |
Neuroinflammation in Gulf War Illness is linked with HMGB1 and complement activation, which can be discerned from brain-derived extracellular vesicles in the blood.
Topics: Animals; Astrocytes; Brain; Complement Activation; Cytokines; DEET; Disease Models, Animal; Encephal | 2019 |
Mood and memory deficits in a model of Gulf War illness are linked with reduced neurogenesis, partial neuron loss, and mild inflammation in the hippocampus.
Topics: Animals; Anxiety; Cell Death; Cholinesterase Inhibitors; DEET; Depression; Disease Models, Animal; H | 2013 |
Corticosterone primes the neuroinflammatory response to DFP in mice: potential animal model of Gulf War Illness.
Topics: Animals; Anti-Inflammatory Agents; Chemical Warfare Agents; Cholinesterase Inhibitors; Corticosteron | 2015 |
DEET potentiates the development and persistence of anticholinesterase dependent chronic pain signs in a rat model of Gulf War Illness pain.
Topics: Animals; Cholinesterase Inhibitors; Chronic Pain; DEET; Disease Models, Animal; Drug Synergism; Inse | 2017 |
Insect repellents and sunscreen: implications for personal protection strategies against mosquito-borne disease.
Topics: Aedes; Analysis of Variance; Animals; DEET; Disease Models, Animal; Humans; Insect Repellents; Insec | 2009 |
Lipidomic profiling of phosphocholine-containing brain lipids in mice with sensorimotor deficits and anxiety-like features after exposure to Gulf War agents.
Topics: Animals; Anxiety; Ataxia; Brain Chemistry; Cerebral Cortex; DEET; Dentate Gyrus; Disease Models, Ani | 2012 |
Evaluation of immunotoxicity induced by single or concurrent exposure to N,N-diethyl-m-toluamide (DEET), pyridostigmine bromide (PYR), and JP-8 jet fuel.
Topics: Animals; Cholinesterase Inhibitors; DEET; Disease Models, Animal; Drug Interactions; Female; Hydroca | 2001 |
The potential use of N,N-diethyl-m-toluamide (DEET) as a prophylactic agent in the control of schistosomiasis.
Topics: Administration, Topical; Animals; DEET; Disease Models, Animal; Insect Repellents; Liver; Male; Mice | 1999 |
Stress and combined exposure to low doses of pyridostigmine bromide, DEET, and permethrin produce neurochemical and neuropathological alterations in cerebral cortex, hippocampus, and cerebellum.
Topics: Animals; Cerebellum; Cerebral Cortex; Cholinesterase Inhibitors; Cognition Disorders; DEET; Disease | 2004 |
Pathological implications of iNOS expression in central white matter: an ex vivo study of optic nerves from rats with experimental allergic encephalomyelitis.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Arginine; Biomarkers; CD11b Antigen; CD2 An | 2005 |
Evaluation of N,N-diethyl-m-toluamide (DEET) as a topical agent for preventing skin penetration by cercariae of Schistosoma mansoni.
Topics: Administration, Topical; Animals; DEET; Disease Models, Animal; Insect Repellents; Male; Mice; Micro | 1998 |
Dermal absorption of the insect repellent DEET (N,N-diethyl-m-toluamide) in rats and monkeys: effect of anatomical site and multiple exposure.
Topics: Animals; Arm; Benzamides; Chromatography, High Pressure Liquid; DEET; Disease Models, Animal; Forehe | 1989 |