decursin and Sarcoma-180

The in vivo anti-tumor activities of decursinol angelate (1) and decursin (2) isolated from the roots of Angelica gigas were investigated. These two compounds, when administered consecutively for 9 days at 50 and 100 mg/kg i.p. in mice, caused a significant increase in the life span and a significant decrease in the tumor weight and volume of mice inoculated with Sarcoma-180 tumor cells. These results suggest that decursinol angelate (1) and decursin (2) from A. gigas have anti-tumor activities.

Topics: Angelica; Animals; Antineoplastic Agents, Phytogenic; Benzopyrans; Butyrates; Cell Line, Tumor; Fluorouracil; Injections, Intraperitoneal; Korea; Male; Medicine, East Asian Traditional; Mice; Mice, Inbred ICR; Neoplasm Transplantation; Neoplasms; Plant Extracts; Plant Roots; Sarcoma 180; Survival Rate