decanoic acid has been researched along with Seizures in 5 studies
decanoate : A fatty acid anion 10:0 that is the conjugate base of decanoic acid.
decanoic acid : A C10, straight-chain saturated fatty acid.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Decanoic acid, a component of medium-chain triclycerides, contributes to seizure control through direct α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor inhibition, whereas drugs targeting lactate dehydrogenase reduce seizures through inhibition of a metabolic pathway." | 4.95 | New insights into the mechanisms of the ketogenic diet. ( Boison, D, 2017) |
| "Decanoic acid acts as a non-competitive antagonist at therapeutically relevant concentrations, in a voltage- and subunit-dependent manner, and this is sufficient to explain its antiseizure effects." | 1.43 | Seizure control by decanoic acid through direct AMPA receptor inhibition. ( Augustin, K; Boddum, K; Chang, P; Chen, PE; Hardege, JD; Sun, M; Terschak, JA; Walker, MC; Williams, RS; Williams, S, 2016) |
| "PTZ) seizure tests in mice." | 1.42 | Acute anticonvulsant effects of capric acid in seizure tests in mice. ( Czuczwar, SJ; Gasior, M; Nieoczym, D; Socała, K; Wlaź, P; Żarnowska, I; Żarnowski, T, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Augustin, K | 2 |
| Khabbush, A | 1 |
| Williams, S | 2 |
| Eaton, S | 1 |
| Orford, M | 1 |
| Cross, JH | 1 |
| Heales, SJR | 1 |
| Walker, MC | 2 |
| Williams, RSB | 1 |
| Enderlin, J | 1 |
| Loussouarn, A | 1 |
| Benoist, JF | 1 |
| Dozières-Puyravel, B | 1 |
| Auvin, S | 1 |
| Wlaź, P | 1 |
| Socała, K | 1 |
| Nieoczym, D | 1 |
| Żarnowski, T | 1 |
| Żarnowska, I | 1 |
| Czuczwar, SJ | 1 |
| Gasior, M | 1 |
| Chang, P | 1 |
| Boddum, K | 1 |
| Sun, M | 1 |
| Terschak, JA | 1 |
| Hardege, JD | 1 |
| Chen, PE | 1 |
| Williams, RS | 1 |
| Boison, D | 1 |
2 reviews available for decanoic acid and Seizures
| Article | Year |
|---|---|
Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders.
Topics: Alzheimer Disease; Caprylates; Decanoic Acids; Diabetes Mellitus; Diet, Ketogenic; Humans; Neoplasms | 2018 |
New insights into the mechanisms of the ketogenic diet.
Topics: Anticonvulsants; Decanoic Acids; Diet, Ketogenic; Epilepsy; Humans; Seizures | 2017 |
3 other studies available for decanoic acid and Seizures
| Article | Year |
|---|---|
Absence of increased blood decanoic acid levels in children with epilepsy treated with classic ketogenic diet.
Topics: Adolescent; Anticonvulsants; Child; Decanoic Acids; Diet, Ketogenic; Epilepsy; Female; Humans; Male; | 2019 |
Acute anticonvulsant effects of capric acid in seizure tests in mice.
Topics: 3-Hydroxybutyric Acid; Animals; Anticonvulsants; Blood Glucose; Brain; Caprylates; Decanoic Acids; D | 2015 |
Seizure control by decanoic acid through direct AMPA receptor inhibition.
Topics: Animals; Decanoic Acids; Female; Hippocampus; Male; Organ Culture Techniques; Protein Binding; Prote | 2016 |