decanoic acid has been researched along with Epilepsy in 5 studies
decanoate : A fatty acid anion 10:0 that is the conjugate base of decanoic acid.
decanoic acid : A C10, straight-chain saturated fatty acid.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Decanoic acid, a component of medium-chain triclycerides, contributes to seizure control through direct α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor inhibition, whereas drugs targeting lactate dehydrogenase reduce seizures through inhibition of a metabolic pathway." | 4.95 | New insights into the mechanisms of the ketogenic diet. ( Boison, D, 2017) |
| "Perampanel (PER) is a non-competitive AMPAR antagonist, and pre-clinical studies have shown the AMPAR-mediated anticonvulsant effects of decanoic acid (DEC), a major medium-chain fatty acid provided in the medium-chain triglyceride ketogenic diet." | 1.56 | Abolishing spontaneous epileptiform activity in human brain tissue through AMPA receptor inhibition. ( Agrawal, S; Greenhill, SD; Lo, WB; Mundil, N; Philip, S; Seri, S; Walsh, R; Wilson, MA; Woodhall, GL; Wright, SK, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 3 (60.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shekhar, N | 1 |
| Tyagi, S | 1 |
| Rani, S | 1 |
| Thakur, AK | 1 |
| Wright, SK | 1 |
| Wilson, MA | 1 |
| Walsh, R | 1 |
| Lo, WB | 1 |
| Mundil, N | 1 |
| Agrawal, S | 1 |
| Philip, S | 1 |
| Seri, S | 1 |
| Greenhill, SD | 1 |
| Woodhall, GL | 1 |
| Warren, EC | 1 |
| Dooves, S | 1 |
| Lugarà, E | 1 |
| Damstra-Oddy, J | 1 |
| Schaf, J | 1 |
| Heine, VM | 1 |
| Walker, MC | 1 |
| Williams, RSB | 1 |
| Enderlin, J | 1 |
| Loussouarn, A | 1 |
| Benoist, JF | 1 |
| Dozières-Puyravel, B | 1 |
| Auvin, S | 1 |
| Boison, D | 1 |
2 reviews available for decanoic acid and Epilepsy
| Article | Year |
|---|---|
Potential of Capric Acid in Neurological Disorders: An Overview.
Topics: Animals; Decanoic Acids; Diet, Ketogenic; Epilepsy; Fatty Acids; Humans; Mammals | 2023 |
New insights into the mechanisms of the ketogenic diet.
Topics: Anticonvulsants; Decanoic Acids; Diet, Ketogenic; Epilepsy; Humans; Seizures | 2017 |
3 other studies available for decanoic acid and Epilepsy
| Article | Year |
|---|---|
Abolishing spontaneous epileptiform activity in human brain tissue through AMPA receptor inhibition.
Topics: Adolescent; Anticonvulsants; Brain; Child; Child, Preschool; Decanoic Acids; Drug Resistant Epilepsy | 2020 |
Decanoic acid inhibits mTORC1 activity independent of glucose and insulin signaling.
Topics: Adaptor Proteins, Signal Transducing; Animals; Astrocytes; Cell Cycle Proteins; Cells, Cultured; Dec | 2020 |
Absence of increased blood decanoic acid levels in children with epilepsy treated with classic ketogenic diet.
Topics: Adolescent; Anticonvulsants; Child; Decanoic Acids; Diet, Ketogenic; Epilepsy; Female; Humans; Male; | 2019 |