debromoaplysiatoxin has been researched along with Cell-Transformation--Neoplastic* in 2 studies
1 review(s) available for debromoaplysiatoxin and Cell-Transformation--Neoplastic
Article | Year |
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Potent tumor promoters other than phorbol ester and their significance.
Topics: Alkaloids; Animals; Cell Adhesion; Cell Aggregation; Cell Transformation, Neoplastic; Enzyme Induction; Humans; Isomerism; Lactones; Lyngbya Toxins; Marine Toxins; Mice; Mollusk Venoms; Neoplasms; Ornithine Decarboxylase; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
1 other study(ies) available for debromoaplysiatoxin and Cell-Transformation--Neoplastic
Article | Year |
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Bromine residue at hydrophilic region influences biological activity of aplysiatoxin, a tumor promoter.
Aplysiatoxin and debromoaplysiatoxin, which are isolated from the seaweed, Lyngbya gracilis, differ in their chemical structure only by the presence or absence of a bromine residue in the hydrophilic region. The function and the structure-activity relation of the hydrophilic region are not known. Aplysiatoxin increased malignant transformation, stimulated DNA synthesis, and inhibited the binding of phorbol-12,13-dibutyrate and epidermal growth factor to cell receptors. Debromoaplysiatoxin inhibited the binding of these two substances as strongly as aplysiatoxin but did not increase malignant transformation or stimulate DNA synthesis. These results indicate that a slight change in the chemical structure of the hydrophilic region of aplysiatoxin affects its abilities to increase cell transformation and stimulate DNA synthesis and that the abilities of the tumor promoters to inhibit the binding of phorbol-12,13-dibutyrate and epidermal growth factor are dissociable from their abilities to increase cell transformation and stimulate DNA synthesis under some circumstances. Topics: Animals; Caenorhabditis elegans Proteins; Carcinogens; Carrier Proteins; Cell Line; Cell Transformation, Neoplastic; Chemical Phenomena; Chemistry; DNA; Epidermal Growth Factor; ErbB Receptors; Lactones; Lyngbya Toxins; Mice; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1983 |