debrisoquin has been researched along with Torsade de Pointes in 1 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Terodiline has concentration dependent QT prolonging effects and thus the potential for cardiotoxicity." | 1.31 | CYP2D6 and CYP2C19 genotypes of patients with terodiline cardiotoxicity identified through the yellow card system. ( Daly, AK; Ford, GA; Wood, SM, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ford, GA | 1 |
| Wood, SM | 1 |
| Daly, AK | 1 |
1 other study available for debrisoquin and Torsade de Pointes
| Article | Year |
|---|---|
CYP2D6 and CYP2C19 genotypes of patients with terodiline cardiotoxicity identified through the yellow card system.
Topics: Aged; Aged, 80 and over; Alleles; Aryl Hydrocarbon Hydroxylases; Butylamines; Cytochrome P-450 CYP2C | 2000 |