debrisoquin has been researched along with Sensitivity and Specificity in 9 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (66.67) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nielsen, KA | 1 |
| Hansen, EL | 1 |
| Gille, S | 1 |
| Anthony, LB | 1 |
| Boeve, TJ | 1 |
| Hande, KR | 1 |
| Brøsen, K | 1 |
| Nielsen, PN | 1 |
| Brusgaard, K | 1 |
| Gram, LF | 1 |
| Skjødt, K | 1 |
| Bozkurt, A | 1 |
| Basci, NE | 1 |
| Isimer, A | 1 |
| Kayaalp, SO | 1 |
| Koyama, E | 1 |
| Kikuchi, Y | 1 |
| Echizen, H | 1 |
| Chiba, K | 1 |
| Ishizaki, T | 1 |
| Cifuentes, A | 1 |
| Valencia, J | 1 |
| Sanz, E | 1 |
| Sánchez, MJ | 1 |
| Rodríguez-Delgado, MA | 1 |
| Scott, RJ | 1 |
| Palmer, J | 1 |
| Lewis, IA | 1 |
| Pleasance, S | 1 |
| Pereira, VA | 1 |
| Auler, JO | 1 |
| Carmona, MJ | 1 |
| Mateus, FH | 1 |
| Lanchote, VL | 1 |
| Breimer, DD | 1 |
| Santos, SR | 1 |
| Haffen, E | 1 |
| Paintaud, G | 1 |
| Berard, M | 1 |
| Masuyer, C | 1 |
| Bechtel, Y | 1 |
| Bechtel, PR | 1 |
9 other studies available for debrisoquin and Sensitivity and Specificity
| Article | Year |
|---|---|
Genotyping of the cytochrome P450 2D6 4469 C>T polymorphism using SimpleProbes.
Topics: Biological Availability; Costs and Cost Analysis; Cytochrome P-450 Enzyme System; Debrisoquin; Enzym | 2007 |
Cytochrome P-450IID6 phenotyping in cancer patients: debrisoquin and dextromethorphan as probes.
Topics: Aged; Chromatography, Gas; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome | 1995 |
CYP2D6 genotype determination in the Danish population.
Topics: Adolescent; Adult; Alleles; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; De | 1994 |
Determination of debrisoquine and 4-hydroxydebrisoquine in urine by high-performance liquid chromatography with fluorescence detection after solid-phase extraction.
Topics: Acetonitriles; Chromatography, High Pressure Liquid; Debrisoquin; Humans; Phosphates; Polymorphism, | 1993 |
Simultaneous high-performance liquid chromatography-electrochemical detection determination of imipramine, desipramine, their 2-hydroxylated metabolites, and imipramine N-oxide in human plasma and urine: preliminary application to oxidation pharmacogeneti
Topics: Arylsulfatases; Calibration; Chromatography, High Pressure Liquid; Debrisoquin; Desipramine; Electro | 1993 |
Separation and quantitation of debrisoquine and 4-hydroxydebrisoquine in human urine by capillary electrophoresis and high-performance liquid chromatography.
Topics: Antihypertensive Agents; Chromatography, High Pressure Liquid; Circadian Rhythm; Debrisoquin; Electr | 1997 |
Determination of a 'GW cocktail' of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry.
Topics: Automation; Caffeine; Chlorzoxazone; Chromatography, Gas; Chromatography, High Pressure Liquid; Cyto | 1999 |
A micromethod for quantitation of debrisoquine and 4-hydroxydebrisoquine in urine by liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Debrisoquin; Female; Fluorometry; Hum | 2000 |
On the assessment of drug metabolism by assays of codeine and its main metabolites.
Topics: Adult; Chromatography, High Pressure Liquid; Codeine; Cytochrome P-450 CYP2D6; Debrisoquin; Dextrome | 2000 |