Page last updated: 2024-10-25

debrisoquin and Seizures

debrisoquin has been researched along with Seizures in 1 studies

Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
" In dogs only, seizures appeared within 10-15 min after dosage with minaprine at 20 mg/kg, when the concentrations of minaprine in erythrocytes (6."1.28Disposition of minaprine in animals and in human extensive and limited debrisoquine hydroxylators. ( Berger, Y; Bonnet, JM; Davi, H, 1992)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Davi, H1
Bonnet, JM1
Berger, Y1

Other Studies

1 other study available for debrisoquin and Seizures

ArticleYear
Disposition of minaprine in animals and in human extensive and limited debrisoquine hydroxylators.
    Xenobiotica; the fate of foreign compounds in biological systems, 1992, Volume: 22, Issue:2

    Topics: Adult; Animals; Antidepressive Agents; Debrisoquin; Dogs; Feces; Humans; Hydroxylation; Macaca fasci

1992