debrisoquin has been researched along with Seizures in 1 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In dogs only, seizures appeared within 10-15 min after dosage with minaprine at 20 mg/kg, when the concentrations of minaprine in erythrocytes (6." | 1.28 | Disposition of minaprine in animals and in human extensive and limited debrisoquine hydroxylators. ( Berger, Y; Bonnet, JM; Davi, H, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Davi, H | 1 |
| Bonnet, JM | 1 |
| Berger, Y | 1 |
1 other study available for debrisoquin and Seizures
| Article | Year |
|---|---|
Disposition of minaprine in animals and in human extensive and limited debrisoquine hydroxylators.
Topics: Adult; Animals; Antidepressive Agents; Debrisoquin; Dogs; Feces; Humans; Hydroxylation; Macaca fasci | 1992 |