debrisoquin has been researched along with Schizophrenia in 14 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with chlorpromazine (100 or 150 mg daily) significantly increased the debrisoquine metabolic ratio in nine patients (P less than 0." | 1.28 | Debrisoquine oxidation in an Italian population: a study in healthy subjects and in schizophrenic patients. ( Benitez, J; Calandra, S; Campo, GM; Caputi, AP; Carrillo, JA; Spina, E, 1992) |
| "Debrisoquin is a drug that suppresses the peripheral formation of homovanillic acid without affecting the central formation." | 1.27 | Effects of debrisoquin and haloperidol on plasma homovanillic acid concentration in schizophrenic patients. ( Davidson, M; Davis, BM; Davis, KL; Freed, LB; Lesser, JC; Losonczy, MF; Mohs, RC; Mykytyn, VV; Powchik, P, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (50.00) | 18.7374 |
| 1990's | 7 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amin, F | 1 |
| Davidson, M | 3 |
| Kahn, RS | 1 |
| Schmeidler, J | 1 |
| Stern, R | 1 |
| Knott, PJ | 1 |
| Apter, S | 1 |
| Miller, AL | 2 |
| Maas, JW | 4 |
| Contreras, S | 1 |
| Seleshi, E | 4 |
| True, JE | 1 |
| Bowden, C | 1 |
| Castiglioni, J | 1 |
| Contreras, SA | 3 |
| Berman, N | 1 |
| Bowden, CL | 3 |
| Javors, MA | 1 |
| Weintraub, S | 1 |
| Spina, E | 2 |
| Campo, GM | 1 |
| Calandra, S | 1 |
| Caputi, AP | 2 |
| Carrillo, JA | 1 |
| Benitez, J | 2 |
| Dahl, ML | 1 |
| Ekqvist, B | 1 |
| Widén, J | 1 |
| Bertilsson, L | 1 |
| Konicki, PE | 1 |
| Owen, RR | 1 |
| Litman, RE | 1 |
| Pickar, D | 2 |
| Meyer, JW | 1 |
| Woggon, B | 1 |
| Baumann, P | 1 |
| Meyer, UA | 1 |
| Tang, SW | 1 |
| Breier, A | 1 |
| Kelsoe, J | 1 |
| Buemi, AL | 1 |
| Cobaleda, J | 1 |
| Garcia, MA | 1 |
| Llerena, A | 1 |
| Piña, B | 1 |
| Losonczy, MF | 2 |
| Mohs, RC | 2 |
| Powchick, P | 1 |
| Freed, LB | 2 |
| Kaminsky, R | 1 |
| Davis, KL | 2 |
| Lesser, JC | 1 |
| Powchik, P | 1 |
| Davis, BM | 1 |
| Mykytyn, VV | 1 |
2 reviews available for debrisoquin and Schizophrenia
| Article | Year |
|---|---|
Relevance of polymorphic drug oxidation in the use of neuroleptics in schizophrenia.
Topics: Amoxapine; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Asian People; Chlorpromazine; Deb | 1986 |
Plasma homovanillic acid as an index of central dopaminergic activity: studies in schizophrenic patients.
Topics: Animals; Antipsychotic Agents; Brain; Cerebral Cortex; Debrisoquin; Dopamine; Homovanillic Acid; Hum | 1988 |
2 trials available for debrisoquin and Schizophrenia
| Article | Year |
|---|---|
Acute effects of neuroleptics on unmedicated schizophrenic patients and controls.
Topics: Adult; Antipsychotic Agents; Brain; Debrisoquin; Dopamine; Haloperidol; Homovanillic Acid; Humans; M | 1993 |
Studies of catecholamine metabolism in schizophrenia/psychosis--I.
Topics: Adult; Aged; Analysis of Variance; Blood Platelets; Catecholamines; Debrisoquin; Double-Blind Method | 1993 |
10 other studies available for debrisoquin and Schizophrenia
| Article | Year |
|---|---|
Assessment of the central dopaminergic index of plasma HVA in schizophrenia.
Topics: Brain; Debrisoquin; Dopamine; Homovanillic Acid; Humans; Male; Methoxyhydroxyphenylglycol; Neurons; | 1995 |
Debrisoquine oxidation in an Italian population: a study in healthy subjects and in schizophrenic patients.
Topics: Adult; Chlorpromazine; Debrisoquin; Female; Humans; Italy; Male; Middle Aged; Oxidation-Reduction; P | 1992 |
Disposition of the neuroleptic zuclopenthixol cosegregates with the polymorphic hydroxylation of debrisoquine in humans.
Topics: Administration, Oral; Adult; Clopenthixol; Debrisoquin; Female; Humans; Hydroxylation; Male; Perphen | 1991 |
The acute effects of central- and peripheral-acting dopamine antagonists on plasma HVA in schizophrenic patients.
Topics: Adult; Debrisoquin; Domperidone; Female; Fluphenazine; Homovanillic Acid; Humans; Male; Receptors, D | 1991 |
Clinical implications of slow sulphoxidation of thioridazine in a poor metabolizer of the debrisoquine type.
Topics: Adult; Debrisoquin; Humans; Oxidation-Reduction; Polymorphism, Genetic; Schizophrenia; Thioridazine | 1990 |
Debrisoquine oxidation in schizophrenic patients treated with neuroleptics.
Topics: Adult; Aged; Antipsychotic Agents; Chlorpromazine; Debrisoquin; Female; Humans; Hydroxylation; Isoqu | 1988 |
Dopamine metabolism and disposition in schizophrenic patients. Studies using debrisoquin.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Aged; Blood Platelets; Brain; Debrisoquin; Dopamine; Homovani | 1988 |
Effects of debrisoquin on plasma homovanillic acid concentration in schizophrenic patients.
Topics: Adult; Debrisoquin; Homovanillic Acid; Humans; Isoquinolines; Male; Schizophrenia | 1987 |
Effects of debrisoquin and haloperidol on plasma homovanillic acid concentration in schizophrenic patients.
Topics: Adult; Debrisoquin; Drug Therapy, Combination; Haloperidol; Homovanillic Acid; Humans; Isoquinolines | 1987 |
Increase in human urine homovanillic acid concentration after neuroleptic treatment is the same with or without debrisoquin administration.
Topics: Brain; Debrisoquin; Dopamine; Haloperidol; Homovanillic Acid; Humans; Isoquinolines; Male; Schizophr | 1987 |