debrisoquin has been researched along with Rheumatoid Arthritis in 4 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beyeler, C | 1 |
| Daly, AK | 1 |
| Armstrong, M | 1 |
| Astbury, C | 1 |
| Bird, HA | 1 |
| Idle, JR | 1 |
| Benitez, J | 1 |
| Ladero, JM | 1 |
| Andres, MP | 1 |
| Jover, JA | 1 |
| Morado, C | 1 |
| Bañares, A | 1 |
| Gustafsson, LL | 1 |
| Eriksson, LS | 1 |
| Dahl, ML | 1 |
| Eleborg, L | 1 |
| Ericzon, BG | 1 |
| Nyberg, A | 1 |
| Skeith, KJ | 1 |
| Hussain, MS | 1 |
| Coutts, RT | 1 |
| Ramos-Remus, C | 1 |
| Avina-Zubieta, JA | 1 |
| Russell, AS | 1 |
1 trial available for debrisoquin and Rheumatoid Arthritis
| Article | Year |
|---|---|
Adverse drug reactions and debrisoquine/sparteine (P450IID6) polymorphism in patients with fibromyalgia.
Topics: Adult; Analgesics; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Age | 1997 |
3 other studies available for debrisoquin and Rheumatoid Arthritis
| Article | Year |
|---|---|
Phenotype/genotype relationships for the cytochrome P450 enzyme CYP2D6 in rheumatoid arthritis: influence of drug therapy and disease activity.
Topics: Adult; Aged; Alleles; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cytochrome P-450 CYP2D6; Cyto | 1994 |
Debrisoquine oxidation polymorphism in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Debrisoquin; Female; Humans; Male; Middle Aged; Oxidation-Reduction; Phenotyp | 1994 |
Cyclophosphamide-induced acute liver failure requiring transplantation in a patient with genetically deficient debrisoquine metabolism: a causal relationship?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cyclophosphamide; Cytochrome P-450 CYP2D6; Debrisoquin; | 1996 |