debrisoquin has been researched along with Renal Insufficiency in 1 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Renal failure was induced by five-sixths nephrectomy (NR), bilateral ureter ligation (BUL), the intramuscular injection of glycerol (GL), and the intraperitoneal injection of cisplatin (CDDP)." | 1.32 | The hepatic and intestinal metabolic activities of P450 in rats with surgery- and drug-induced renal dysfunction. ( Hashimoto, Y; Hasunuma, M; Okabe, H, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Okabe, H | 1 |
| Hasunuma, M | 1 |
| Hashimoto, Y | 1 |
1 other study available for debrisoquin and Renal Insufficiency
| Article | Year |
|---|---|
The hepatic and intestinal metabolic activities of P450 in rats with surgery- and drug-induced renal dysfunction.
Topics: Animals; Cisplatin; Cytochrome P-450 Enzyme System; Debrisoquin; Glycerol; Hydroxylation; Hydroxytes | 2003 |