debrisoquin has been researched along with Psychoses in 3 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| LLerena, A | 2 |
| Berecz, R | 2 |
| de la Rubia, A | 2 |
| Dorado, P | 2 |
| Fernández-Salguero, P | 1 |
| Dahl, ML | 1 |
| Amin, F | 1 |
| Davidson, M | 1 |
| Kahn, RS | 1 |
| Schmeidler, J | 1 |
| Stern, R | 1 |
| Knott, PJ | 1 |
| Apter, S | 1 |
2 trials available for debrisoquin and Psychoses
| Article | Year |
|---|---|
QTc interval lengthening and debrisoquine metabolic ratio in psychiatric patients treated with oral haloperidol monotherapy.
Topics: Administration, Oral; Adult; Aged; Antipsychotic Agents; Debrisoquin; Female; Gas Chromatography-Mas | 2002 |
Thioridazine steady-state plasma concentrations are influenced by tobacco smoking and CYP2D6, but not by the CYP2C9 genotype.
Topics: Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-45 | 2003 |
1 other study available for debrisoquin and Psychoses
| Article | Year |
|---|---|
Assessment of the central dopaminergic index of plasma HVA in schizophrenia.
Topics: Brain; Debrisoquin; Dopamine; Homovanillic Acid; Humans; Male; Methoxyhydroxyphenylglycol; Neurons; | 1995 |