debrisoquin has been researched along with Pregnancy in 5 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Kynuramine was used as substrate for both enzymes." | 1.28 | The effect of debrisoquin on MAO A and MAO B activities. ( Abell, CW; Bembenek, ME; Bowden, CL; Javors, MA; Maas, JW, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Roots, I | 1 |
| Shaw, GL | 1 |
| Weiffenbach, B | 1 |
| Falk, RT | 1 |
| Frame, JN | 1 |
| Issaq, HJ | 1 |
| Moir, DT | 1 |
| Caporaso, N | 1 |
| Smith, AJ | 1 |
| Javors, MA | 1 |
| Bembenek, ME | 1 |
| Bowden, CL | 1 |
| Abell, CW | 1 |
| Maas, JW | 1 |
| Pasanen, M | 1 |
| Taskinen, T | 1 |
| Sotaniemi, EA | 1 |
| Kairaluoma, M | 1 |
| Pelkonen, O | 1 |
5 other studies available for debrisoquin and Pregnancy
| Article | Year |
|---|---|
[Genetic causes for the variability of effects and side effects of drugs].
Topics: Debrisoquin; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hydroxylation; Kinetic | 1982 |
Frequency of the variant allele CYP2D6(C) among North American Caucasian lung cancer patients and controls.
Topics: Alleles; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Case-Control Studies; Cytochrome P-450 CYP | 1997 |
Management of hypertension.
Topics: Adrenergic beta-Antagonists; Age Factors; Bethanidine; Clonidine; Debrisoquin; Decision Making; Diur | 1975 |
The effect of debrisoquin on MAO A and MAO B activities.
Topics: Biogenic Amines; Debrisoquin; Female; Humans; Isoquinolines; Kinetics; Kynuramine; Monoamine Oxidase | 1989 |
Inhibitor panel studies of human hepatic and placental cytochrome P-450-associated monooxygenase activities.
Topics: Aminoglutethimide; Animals; Benzoflavones; Cimetidine; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enz | 1988 |