debrisoquin has been researched along with Parkinson Disease in 21 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The debrisoquine test was used to evaluate the capacity for hydroxylation of twenty patients treated for Parkinson's disease." | 1.28 | [Hydroxylation of debrisoquin in Parkinson's disease]. ( Allain, H; Bentué-Ferrer, D; Brunet-Bourgin, F; Meillard, MN; Morel, G, 1990) |
| "It is postulated that Parkinson's disease is the result of environmental factors acting on genetically susceptible individuals against a background of normal ageing." | 1.27 | Ecogenetics of Parkinson's disease: 4-hydroxylation of debrisoquine. ( Barbeau, A; Cloutier, T; Paris, S; Plasse, L; Poirier, J; Roy, M, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (23.81) | 18.7374 |
| 1990's | 16 (76.19) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ray-Chaudhuri, K | 1 |
| Smith, C | 1 |
| Gough, AC | 1 |
| Novak, N | 1 |
| Chamoun, V | 1 |
| Wolf, CR | 1 |
| Leigh, PN | 1 |
| Bordet, R | 1 |
| Broly, F | 1 |
| Destée, A | 1 |
| Libersa, C | 1 |
| Rose, S | 1 |
| Hindmarsh, JG | 1 |
| Steiger, MJ | 2 |
| Bhatt, M | 1 |
| Quinn, NP | 2 |
| Jenner, P | 1 |
| Marsden, CD | 2 |
| Tsuneoka, Y | 1 |
| Matsuo, Y | 1 |
| Ichikawa, Y | 1 |
| Watanabe, Y | 1 |
| McCann, SJ | 1 |
| Pond, SM | 1 |
| James, KM | 1 |
| Le Couteur, DG | 1 |
| Hubble, JP | 1 |
| Kurth, JH | 1 |
| Glatt, SL | 1 |
| Kurth, MC | 1 |
| Schellenberg, GD | 1 |
| Hassanein, RE | 1 |
| Lieberman, A | 1 |
| Koller, WC | 1 |
| Christensen, PM | 1 |
| Gøtzsche, PC | 1 |
| Brøsen, K | 1 |
| Liu, TY | 1 |
| Chi, CW | 1 |
| Yang, JC | 1 |
| Cheung, SC | 1 |
| Liu, HC | 1 |
| Lledo, P | 1 |
| Turner, P | 1 |
| Jenner, PG | 1 |
| Tanner, CM | 2 |
| Kallio, J | 1 |
| Marttila, RJ | 1 |
| Rinne, UK | 1 |
| Sonninen, V | 1 |
| Syvälahti, E | 1 |
| Meillard, MN | 1 |
| Bentué-Ferrer, D | 1 |
| Brunet-Bourgin, F | 1 |
| Morel, G | 1 |
| Allain, H | 1 |
| Gudjonsson, O | 1 |
| Sanz, E | 1 |
| Alván, G | 1 |
| Aquilonius, SM | 1 |
| Reviriego, J | 1 |
| Ohta, S | 1 |
| Tachikawa, O | 1 |
| Makino, Y | 1 |
| Tasaki, Y | 1 |
| Hirobe, M | 1 |
| Benitez, J | 1 |
| Ladero, JM | 1 |
| Jimenez-Jimenez, FJ | 1 |
| Martinez, C | 1 |
| Puerto, AM | 1 |
| Valdivielso, MJ | 1 |
| Llerena, A | 1 |
| Cobaleda, J | 1 |
| Muñoz, JJ | 1 |
| Barbeau, A | 2 |
| Cloutier, T | 3 |
| Roy, M | 3 |
| Plasse, L | 1 |
| Paris, S | 2 |
| Poirier, J | 2 |
| Campanella, G | 1 |
| Borm, PJ | 1 |
| Van Vliet, C | 1 |
| Golbe, LI | 1 |
| Bernholc, AA | 1 |
| Duvoisin, RC | 1 |
3 reviews available for debrisoquin and Parkinson Disease
| Article | Year |
|---|---|
The association between polymorphisms in the cytochrome P-450 2D6 gene and Parkinson's disease: a case-control study and meta-analysis.
Topics: Aged; Case-Control Studies; Cytochrome P-450 CYP2D6; Debrisoquin; Female; Genotype; Humans; Male; Pa | 1997 |
Liver enzyme abnormalities in Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; L | 1991 |
Abnormal liver enzyme-mediated metabolism in Parkinson's disease: a second look.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; L | 1991 |
2 trials available for debrisoquin and Parkinson Disease
| Article | Year |
|---|---|
Debrisoquine hydroxylation genotype in familial forms of idiopathic Parkinson's disease.
Topics: Aged; Base Sequence; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; DNA; Fema | 1996 |
Plasma HVA levels following debrisoquine administration do not reflect cerebral dopamine loss in early Parkinson's disease.
Topics: Adult; Aged; Biomarkers; Cerebral Cortex; Debrisoquin; Dopamine; Female; Homovanillic Acid; Humans; | 1994 |
16 other studies available for debrisoquin and Parkinson Disease
| Article | Year |
|---|---|
Debrisoquine hydroxylase gene polymorphism in Parkinson's disease and amyotrophic lateral sclerosis.
Topics: Acetyltransferases; Amyotrophic Lateral Sclerosis; Cytochrome P-450 Enzyme System; Debrisoquin; Geno | 1995 |
Genetic analysis of the CYP2D6 gene in patients with Parkinson's disease.
Topics: Alleles; Cytochrome P-450 CYP2D6; Debrisoquin; Deoxyribonucleases, Type II Site-Specific; Genotype; | 1998 |
Gene-toxin interaction as a putative risk factor for Parkinson's disease with dementia.
Topics: Aged; Apolipoproteins; Case-Control Studies; Comorbidity; Debrisoquin; Dementia; Environmental Expos | 1998 |
The sparteine/debrisoquine (CYP2D6) oxidation polymorphism and the risk of Parkinson's disease: a meta-analysis.
Topics: Aged; Case-Control Studies; Cohort Studies; Cytochrome P-450 CYP2D6; Debrisoquin; Genetic Heterogene | 1998 |
Debrisoquine metabolism in Chinese patients with Alzheimer's and Parkinson's diseases.
Topics: Aged; Alzheimer Disease; China; Debrisoquin; Female; Humans; Male; Oxidation-Reduction; Parkinson Di | 1992 |
Debrisoquine hydroxylation in Parkinson's disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; | 1992 |
Debrisoquine oxidation in Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin | 1991 |
[Hydroxylation of debrisoquin in Parkinson's disease].
Topics: Adult; Aged; Debrisoquin; Female; Humans; Hydroxylation; Isoquinolines; Male; Middle Aged; Parkinson | 1990 |
Poor hydroxylator phenotypes of debrisoquine and S-mephenytoin are not over-represented in a group of patients with Parkinson's disease.
Topics: Aged; Debrisoquin; Female; Humans; Hydroxylation; Male; Mephenytoin; Middle Aged; Parkinson Disease; | 1990 |
Metabolism and brain accumulation of tetrahydroisoquinoline (TIQ) a possible parkinsonism inducing substance, in an animal model of a poor debrisoquine metabolizer.
Topics: Animals; Brain; Chemical Phenomena; Chemistry; Debrisoquin; Disease Models, Animal; Female; Gas Chro | 1990 |
Oxidative polymorphism of debrisoquine in Parkinson's disease.
Topics: Adult; Aged; Debrisoquin; Female; Humans; Isoquinolines; Male; Middle Aged; Oxidation-Reduction; Par | 1990 |
Ecogenetics of Parkinson's disease: 4-hydroxylation of debrisoquine.
Topics: Adult; Aging; Debrisoquin; Female; Humans; Hydroxylation; Isoquinolines; Liver; Middle Aged; Parkins | 1985 |
Debrisoquine metabolism in parkinsonian patients treated with antihistamine drugs.
Topics: Debrisoquin; Drug Interactions; Histamine H1 Antagonists; Humans; Isoquinolines; Parkinson Disease | 1987 |
Susceptibility in Parkinson's disease. 'Of mice and men'.
Topics: Animals; Cytochrome P-450 Enzyme System; Debrisoquin; Free Radicals; Humans; Mice; Models, Biologica | 1988 |
Smoking, cancer, and Parkinson's disease.
Topics: Debrisoquin; Humans; Hydroxylation; Isoquinolines; Parkinson Disease; Phenotype; Smoking | 1987 |
Smoking, cancer, and Parkinson's disease.
Topics: Aged; Debrisoquin; Female; Humans; Hydroxylation; Isoquinolines; Kinetics; Male; Middle Aged; Neopla | 1986 |