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debrisoquin and Neoplasms

debrisoquin has been researched along with Neoplasms in 18 studies

Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
" The variation in plasma morphine concentrations was higher than that of oxycodone, consistent with the lower bioavailability of morphine."6.69Morphine or oxycodone in cancer pain? ( Heiskanen, TE; Kalso, EA; Ruismäki, PM; Seppälä, TA, 2000)
" Three examples of pharmacogenetic risk factors are discussed: the first two are p450 enzymes whose activity has been associated with susceptibility to lung cancer (debrisoquine hydroxylase, aryl hydrocarbon hydroxylase), and the last, N-acetyltransferase, a non-p450 enzyme, has been associated with bladder cancer susceptibility."3.68Study design and genetic susceptibility factors in the risk assessment of chemical carcinogens. ( Caporaso, N, 1991)
" The variation in plasma morphine concentrations was higher than that of oxycodone, consistent with the lower bioavailability of morphine."2.69Morphine or oxycodone in cancer pain? ( Heiskanen, TE; Kalso, EA; Ruismäki, PM; Seppälä, TA, 2000)
"The application of biomarkers to cancer epidemiology should enhance the validity of exposure and outcome measurement, and strengthen the statistical association between exposure and diseases, thus reducing the possibility of random and systematic error."1.29Sources of bias, effect of confounding in the application of biomarkers to epidemiological studies. ( Boffetta, P, 1995)
"Accordingly, two groups of cancer patients were investigated with debrisoquine, namely Nigerians with hepatocellular and related tumours and white smokers with bronchial carcinoma in the United Kingdom."1.26Population studies of polymorphism in drug oxidation and its relevance to carcinogenesis. ( Idle, JR; Ritchie, JC, 1982)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19907 (38.89)18.7374
1990's10 (55.56)18.2507
2000's1 (5.56)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hanke, JZ1
Nemoto, N1
Ritchie, JC1
Idle, JR1
Vineis, P1
Boffetta, P1
Anthony, LB1
Boeve, TJ1
Hande, KR1
Sinués, B1
Rueda, P1
Benítez, J1
Saenz, MA1
Bernal, ML1
Lanuza, J1
Alda, O1
Tres, A1
Bartolome, M1
Nebert, DW5
Heiskanen, TE1
Ruismäki, PM1
Seppälä, TA1
Kalso, EA1
Caporaso, N1
Sugimura, H1
Caporaso, NE1
Shaw, GL1
Modali, RV1
Gonzalez, FJ3
Hoover, RN1
Resau, JH1
Trump, BF1
Weston, A1
Harris, CC1
Philip, PA1
Lewis, LD1
James, CA1
Rogers, HJ1
Jaiswal, AK1
Meyer, UA1
Barbeau, A1
Roy, M1
Cloutier, T1

Reviews

5 reviews available for debrisoquin and Neoplasms

ArticleYear
[Individual difference in drug metabolism--pharmacogenetical approach].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:5

    Topics: Absorption; Animals; Debrisoquin; Female; Genetics; Guinea Pigs; Humans; Isoquinolines; Kinetics; Mi

1982
Polymorphisms in drug-metabolizing enzymes: what is their clinical relevance and why do they exist?
    American journal of human genetics, 1997, Volume: 60, Issue:2

    Topics: Acetylation; Animals; Arylamine N-Acetyltransferase; Bioethics; Cytochrome P-450 CYP2D6; Debrisoquin

1997
Role of genetics and drug metabolism in human cancer risk.
    Mutation research, 1991, Volume: 247, Issue:2

    Topics: Acetylation; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Debrisoquin; Gene Expres

1991
Hereditary polymorphisms of human drug metabolizing enzymes and cancer susceptibility.
    Birth defects original article series, 1990, Volume: 26, Issue:1

    Topics: Animals; Biotransformation; Carcinogens; Cytochrome P-450 Enzyme System; Debrisoquin; Genetic Predis

1990
Genes encoding drug-metabolizing enzymes: possible role in human disease.
    Basic life sciences, 1988, Volume: 43

    Topics: Acetylation; Acetyltransferases; Chromosome Mapping; Cytochrome P-450 Enzyme System; Debrisoquin; Ge

1988

Trials

1 trial available for debrisoquin and Neoplasms

ArticleYear
Morphine or oxycodone in cancer pain?
    Acta oncologica (Stockholm, Sweden), 2000, Volume: 39, Issue:8

    Topics: Administration, Oral; Adult; Aged; Analgesics, Opioid; Cross-Over Studies; Cytochrome P-450 CYP2D6;

2000

Other Studies

12 other studies available for debrisoquin and Neoplasms

ArticleYear
Genetic susceptibility to toxic substances and its relationship to carcinogenesis.
    IARC scientific publications, 1984, Issue:59

    Topics: Acetylation; alpha 1-Antitrypsin; Aryl Hydrocarbon Hydroxylases; Carcinogens; Debrisoquin; Disease S

1984
Population studies of polymorphism in drug oxidation and its relevance to carcinogenesis.
    IARC scientific publications, 1982, Issue:39

    Topics: Animals; Biotransformation; Carcinoma, Bronchogenic; Debrisoquin; Humans; Isoquinolines; Lung Neopla

1982
Use of biomarkers in epidemiology. The example of metabolic susceptibility to cancer.
    Toxicology letters, 1995, Volume: 77, Issue:1-3

    Topics: Biomarkers; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Disease Susceptibi

1995
Sources of bias, effect of confounding in the application of biomarkers to epidemiological studies.
    Toxicology letters, 1995, Volume: 77, Issue:1-3

    Topics: Bias; Biomarkers; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Diagnostic E

1995
Cytochrome P-450IID6 phenotyping in cancer patients: debrisoquin and dextromethorphan as probes.
    Cancer chemotherapy and pharmacology, 1995, Volume: 36, Issue:2

    Topics: Aged; Chromatography, Gas; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome

1995
Thioether excretion, urinary mutagenicity, and metabolic phenotype in smokers.
    Journal of toxicology and environmental health, 1994, Volume: 43, Issue:3

    Topics: Acetylation; Adult; Biomarkers; Creatinine; Debrisoquin; Female; Genetic Predisposition to Disease;

1994
Identification of genetic differences in drug metabolism: prediction of individual risk of toxicity or cancer.
    Hepatology (Baltimore, Md.), 1991, Volume: 14, Issue:2

    Topics: Alleles; Debrisoquin; Forecasting; Genes; Genetic Predisposition to Disease; Humans; Metabolism; Mut

1991
Study design and genetic susceptibility factors in the risk assessment of chemical carcinogens.
    Annali dell'Istituto superiore di sanita, 1991, Volume: 27, Issue:4

    Topics: Biotransformation; Carcinogens, Environmental; Case-Control Studies; Cytochrome P-450 CYP2D6; Cytoch

1991
Human debrisoquine hydroxylase gene polymorphisms in cancer patients and controls.
    Carcinogenesis, 1990, Volume: 11, Issue:9

    Topics: Adenocarcinoma; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cytochrome P-450 CYP2D6; Cytochrome

1990
Ifosfamide plasma clearance in relation to polymorphic debrisoquine oxidation.
    Cancer chemotherapy and pharmacology, 1988, Volume: 22, Issue:4

    Topics: Adult; Aged; Alkylation; Debrisoquin; Female; Humans; Ifosfamide; Isoquinolines; Male; Middle Aged;

1988
Human P-450 genes: evolution, regulation and possible role in carcinogenesis.
    Biochemical Society transactions, 1987, Volume: 15, Issue:4

    Topics: Aryl Hydrocarbon Hydroxylases; Biological Evolution; Cloning, Molecular; Cytochrome P-450 Enzyme Sys

1987
Smoking, cancer, and Parkinson's disease.
    Annals of neurology, 1986, Volume: 20, Issue:1

    Topics: Aged; Debrisoquin; Female; Humans; Hydroxylation; Isoquinolines; Kinetics; Male; Middle Aged; Neopla

1986