debrisoquin has been researched along with Lymphoma, Non-Hodgkin in 2 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Lymphoma, Non-Hodgkin: Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "101 white British adults with Hodgkin's disease or non-Hodgkin's lymphoma were phenotyped for acetylation status using dapsone and for oxidation status with debrisoquine prior to treatment." | 3.67 | Acetylation and oxidation phenotypes in malignant lymphoma. ( Harper, PG; Philip, PA; Rogers, HJ, 1987) |
| " Food intake reduced the time to peak concentration both in plasma, from 1." | 1.28 | Variability of 6-mercaptopurine pharmacokinetics during oral maintenance therapy of children with acute leukemia. ( Ahström, L; Björk, O; Hayder, S; Lafolie, P; Peterson, C, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lafolie, P | 1 |
| Björk, O | 1 |
| Hayder, S | 1 |
| Ahström, L | 1 |
| Peterson, C | 1 |
| Philip, PA | 1 |
| Rogers, HJ | 1 |
| Harper, PG | 1 |
2 other studies available for debrisoquin and Lymphoma, Non-Hodgkin
| Article | Year |
|---|---|
Variability of 6-mercaptopurine pharmacokinetics during oral maintenance therapy of children with acute leukemia.
Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Debrisoquin; Erythrocytes; Fasting; Femal | 1989 |
Acetylation and oxidation phenotypes in malignant lymphoma.
Topics: Acetylation; Adult; Aged; Dapsone; Debrisoquin; Female; Hodgkin Disease; Humans; Lymphoma; Lymphoma, | 1987 |