debrisoquin has been researched along with Local Neoplasm Recurrence in 1 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Debrisoquine, mephenytoin, and dapsone were used as in vivo probes for the activities of P4502D6, 2CMP, and 3A4, respectively, as well as dapsone for N-acetyltransferase, in order to assess the relationship between such activities and the relative risk of recurrence of bladder cancer." | 7.68 | The ability to 4-hydroxylate debrisoquine is related to recurrence of bladder cancer. ( Branch, RA; Fleming, CM; Kaisary, A; Smith, P; Wilkinson, GR, 1992) |
| " Debrisoquine, mephenytoin, and dapsone were used as in vivo probes for the activities of P4502D6, 2CMP, and 3A4, respectively, as well as dapsone for N-acetyltransferase, in order to assess the relationship between such activities and the relative risk of recurrence of bladder cancer." | 3.68 | The ability to 4-hydroxylate debrisoquine is related to recurrence of bladder cancer. ( Branch, RA; Fleming, CM; Kaisary, A; Smith, P; Wilkinson, GR, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fleming, CM | 1 |
| Kaisary, A | 1 |
| Wilkinson, GR | 1 |
| Smith, P | 1 |
| Branch, RA | 1 |
1 other study available for debrisoquin and Local Neoplasm Recurrence
| Article | Year |
|---|---|
The ability to 4-hydroxylate debrisoquine is related to recurrence of bladder cancer.
Topics: Aged; Biotransformation; Carcinogens, Environmental; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzym | 1992 |