debrisoquin has been researched along with Liver Failure, Acute in 2 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Liver Failure, Acute: A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, RR | 1 |
| Zheng, YW | 1 |
| Li, B | 1 |
| Tsuchida, T | 1 |
| Ueno, Y | 1 |
| Nie, YZ | 1 |
| Taniguchi, H | 1 |
| Gustafsson, LL | 1 |
| Eriksson, LS | 1 |
| Dahl, ML | 1 |
| Eleborg, L | 1 |
| Ericzon, BG | 1 |
| Nyberg, A | 1 |
2 other studies available for debrisoquin and Liver Failure, Acute
| Article | Year |
|---|---|
Human hepatic stem cells transplanted into a fulminant hepatic failure Alb-TRECK/SCID mouse model exhibit liver reconstitution and drug metabolism capabilities.
Topics: Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chimera; Debrisoquin; Diphtheria | 2015 |
Cyclophosphamide-induced acute liver failure requiring transplantation in a patient with genetically deficient debrisoquine metabolism: a causal relationship?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cyclophosphamide; Cytochrome P-450 CYP2D6; Debrisoquin; | 1996 |