debrisoquin has been researched along with Liver Cirrhosis in 2 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| " For the glucuronide conjugate of 4-hydroxyatomoxetine, the mean half-life was longer and the mean area under the concentration-time curve from time 0 to infinity and the maximum concentration were lower (P =." | 1.32 | Effect of hepatic impairment on the pharmacokinetics of atomoxetine and its metabolites. ( Chalon, SA; Desager, JP; Desante, KA; Frye, RF; Golnez, JL; Horsmans, Y; Long, AJ; Sauer, JM; Smith, BP; Thomasson, HR; Witcher, J, 2003) |
| "Pinacidil is an investigational vasodilator currently undergoing clinical trials as an antihypertensive agent." | 1.27 | Effect of cirrhosis and debrisoquin phenotype on the disposition and effects of pinacidil. ( Avant, GR; Hamilton, M; Patel, J; Shaheen, O; Wood, AJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chalon, SA | 1 |
| Desager, JP | 1 |
| Desante, KA | 1 |
| Frye, RF | 1 |
| Witcher, J | 1 |
| Long, AJ | 1 |
| Sauer, JM | 1 |
| Golnez, JL | 1 |
| Smith, BP | 1 |
| Thomasson, HR | 1 |
| Horsmans, Y | 1 |
| Shaheen, O | 1 |
| Patel, J | 1 |
| Avant, GR | 1 |
| Hamilton, M | 1 |
| Wood, AJ | 1 |
2 other studies available for debrisoquin and Liver Cirrhosis
| Article | Year |
|---|---|
Effect of hepatic impairment on the pharmacokinetics of atomoxetine and its metabolites.
Topics: Administration, Oral; Adult; Antidepressive Agents; Area Under Curve; Atomoxetine Hydrochloride; Att | 2003 |
Effect of cirrhosis and debrisoquin phenotype on the disposition and effects of pinacidil.
Topics: Adult; Blood Pressure; Debrisoquin; Drug Interactions; Guanidines; Humans; Isoquinolines; Kinetics; | 1986 |