debrisoquin has been researched along with Libman-Sacks Disease in 3 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oxidative metabolism in patients with systemic lupus erythematosus (SLE) was studied using the antihypertensive drug, debrisoquine." | 1.27 | Altered distribution of debrisoquine oxidation phenotypes in patients with systemic lupus erythematosus. ( Baer, AN; McAllister, CB; Pincus, T; Wilkinson, GR; Woosley, RL, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kortunay, S | 1 |
| Bozkurt, A | 1 |
| Bathum, L | 1 |
| Basci, NE | 1 |
| Calgüneri, M | 1 |
| Brøsen, K | 1 |
| Kayaalp, SO | 1 |
| Seideman, P | 1 |
| Alván, G | 1 |
| Baer, AN | 1 |
| McAllister, CB | 1 |
| Wilkinson, GR | 1 |
| Woosley, RL | 1 |
| Pincus, T | 1 |
1 trial available for debrisoquin and Libman-Sacks Disease
| Article | Year |
|---|---|
CYP2D6 polymorphism in systemic lupus erythematosus patients.
Topics: Adult; Alleles; Cytochrome P-450 CYP2D6; Debrisoquin; Female; Genotype; Humans; Lupus Erythematosus, | 1999 |
2 other studies available for debrisoquin and Libman-Sacks Disease
| Article | Year |
|---|---|
Debrisoquine hydroxylation phenotype in SLE patients.
Topics: Debrisoquin; Humans; Hydroxylation; Isoquinolines; Lupus Erythematosus, Systemic; Phenotype | 1989 |
Altered distribution of debrisoquine oxidation phenotypes in patients with systemic lupus erythematosus.
Topics: Adult; Debrisoquin; Female; Humans; Isoquinolines; Lupus Erythematosus, Systemic; Male; Middle Aged; | 1986 |