debrisoquin has been researched along with Kidney Diseases in 3 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Flecainide disposition was altered in the PMs." | 1.28 | The influence of the sparteine/debrisoquin phenotype on the disposition of flecainide. ( Beckmann, J; Eichelbaum, M; Gross, AS; Gundert-Remy, U; Hertrampf, R; Mikus, G, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dorne, JL | 1 |
| Walton, K | 1 |
| Slob, W | 1 |
| Renwick, AG | 1 |
| Mikus, G | 1 |
| Gross, AS | 1 |
| Beckmann, J | 1 |
| Hertrampf, R | 1 |
| Gundert-Remy, U | 1 |
| Eichelbaum, M | 1 |
| Hamilton, M | 1 |
3 other studies available for debrisoquin and Kidney Diseases
| Article | Year |
|---|---|
Human variability in polymorphic CYP2D6 metabolism: is the kinetic default uncertainty factor adequate?
Topics: Adult; Aged; Aging; Benzhydryl Compounds; Cresols; Cyclohexanols; Cytochrome P-450 CYP2D6; Debrisoqu | 2002 |
The influence of the sparteine/debrisoquin phenotype on the disposition of flecainide.
Topics: Adult; Analysis of Variance; Chromatography, High Pressure Liquid; Debrisoquin; Female; Flecainide; | 1989 |
Hypertension.
Topics: Adrenergic beta-Antagonists; Aortic Diseases; Benzothiadiazines; Brain Diseases; Cerebrovascular Dis | 1974 |