debrisoquin has been researched along with Intraocular Pressure in 3 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Intraocular Pressure: The pressure of the fluids in the eye.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of a single 20 mg oral dose of timolol, a non-selective beta-adrenoceptor antagonist which is subject to hydroxylation in the liver, on intraocular pressure and heart rate were compared in four poor and five extensive debrisoquine metabolizers, using non-contact tonometry and bicycle ergometry." | 7.68 | The effects of timolol on intraocular pressure and exercise heart rate in poor and extensive debrisoquine metabolizers. ( al-Sereiti, MR; Edeki, T; Lledo, P; Turner, P, 1990) |
| "The effects of a single 20 mg oral dose of timolol, a non-selective beta-adrenoceptor antagonist which is subject to hydroxylation in the liver, on intraocular pressure and heart rate were compared in four poor and five extensive debrisoquine metabolizers, using non-contact tonometry and bicycle ergometry." | 3.68 | The effects of timolol on intraocular pressure and exercise heart rate in poor and extensive debrisoquine metabolizers. ( al-Sereiti, MR; Edeki, T; Lledo, P; Turner, P, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huupponen, R | 1 |
| Kaila, T | 1 |
| Lahdes, K | 1 |
| Salminen, L | 1 |
| Iisalo, E | 1 |
| al-Sereiti, MR | 1 |
| Edeki, T | 1 |
| Lledo, P | 1 |
| Turner, P | 1 |
| Hayashi, M | 1 |
| Takase, M | 1 |
3 other studies available for debrisoquin and Intraocular Pressure
| Article | Year |
|---|---|
Systemic absorption of ocular timolol in poor and extensive metabolizers of debrisoquine.
Topics: Absorption; Adult; Blood; Debrisoquin; Female; Humans; Intraocular Pressure; Male; Ophthalmic Soluti | 1991 |
The effects of timolol on intraocular pressure and exercise heart rate in poor and extensive debrisoquine metabolizers.
Topics: Adult; Debrisoquin; Electrocardiography; Exercise; Female; Heart Rate; Humans; Intraocular Pressure; | 1990 |
Population study of poor debrisoquine-type metabolizers of propranolol among Japanese.
Topics: Adult; Blood Pressure; Debrisoquin; Humans; Intraocular Pressure; Isoquinolines; Japan; Male; Popula | 1985 |