debrisoquin has been researched along with Idiopathic Parkinson Disease in 21 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The debrisoquine test was used to evaluate the capacity for hydroxylation of twenty patients treated for Parkinson's disease." | 1.28 | [Hydroxylation of debrisoquin in Parkinson's disease]. ( Allain, H; Bentué-Ferrer, D; Brunet-Bourgin, F; Meillard, MN; Morel, G, 1990) |
| "It is postulated that Parkinson's disease is the result of environmental factors acting on genetically susceptible individuals against a background of normal ageing." | 1.27 | Ecogenetics of Parkinson's disease: 4-hydroxylation of debrisoquine. ( Barbeau, A; Cloutier, T; Paris, S; Plasse, L; Poirier, J; Roy, M, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (23.81) | 18.7374 |
| 1990's | 16 (76.19) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ray-Chaudhuri, K | 1 |
| Smith, C | 1 |
| Gough, AC | 1 |
| Novak, N | 1 |
| Chamoun, V | 1 |
| Wolf, CR | 1 |
| Leigh, PN | 1 |
| Bordet, R | 1 |
| Broly, F | 1 |
| Destée, A | 1 |
| Libersa, C | 1 |
| Rose, S | 1 |
| Hindmarsh, JG | 1 |
| Steiger, MJ | 2 |
| Bhatt, M | 1 |
| Quinn, NP | 2 |
| Jenner, P | 1 |
| Marsden, CD | 2 |
| Tsuneoka, Y | 1 |
| Matsuo, Y | 1 |
| Ichikawa, Y | 1 |
| Watanabe, Y | 1 |
| McCann, SJ | 1 |
| Pond, SM | 1 |
| James, KM | 1 |
| Le Couteur, DG | 1 |
| Hubble, JP | 1 |
| Kurth, JH | 1 |
| Glatt, SL | 1 |
| Kurth, MC | 1 |
| Schellenberg, GD | 1 |
| Hassanein, RE | 1 |
| Lieberman, A | 1 |
| Koller, WC | 1 |
| Christensen, PM | 1 |
| Gøtzsche, PC | 1 |
| Brøsen, K | 1 |
| Liu, TY | 1 |
| Chi, CW | 1 |
| Yang, JC | 1 |
| Cheung, SC | 1 |
| Liu, HC | 1 |
| Lledo, P | 1 |
| Turner, P | 1 |
| Jenner, PG | 1 |
| Tanner, CM | 2 |
| Kallio, J | 1 |
| Marttila, RJ | 1 |
| Rinne, UK | 1 |
| Sonninen, V | 1 |
| Syvälahti, E | 1 |
| Meillard, MN | 1 |
| Bentué-Ferrer, D | 1 |
| Brunet-Bourgin, F | 1 |
| Morel, G | 1 |
| Allain, H | 1 |
| Gudjonsson, O | 1 |
| Sanz, E | 1 |
| Alván, G | 1 |
| Aquilonius, SM | 1 |
| Reviriego, J | 1 |
| Ohta, S | 1 |
| Tachikawa, O | 1 |
| Makino, Y | 1 |
| Tasaki, Y | 1 |
| Hirobe, M | 1 |
| Benitez, J | 1 |
| Ladero, JM | 1 |
| Jimenez-Jimenez, FJ | 1 |
| Martinez, C | 1 |
| Puerto, AM | 1 |
| Valdivielso, MJ | 1 |
| Llerena, A | 1 |
| Cobaleda, J | 1 |
| Muñoz, JJ | 1 |
| Barbeau, A | 2 |
| Cloutier, T | 3 |
| Roy, M | 3 |
| Plasse, L | 1 |
| Paris, S | 2 |
| Poirier, J | 2 |
| Campanella, G | 1 |
| Borm, PJ | 1 |
| Van Vliet, C | 1 |
| Golbe, LI | 1 |
| Bernholc, AA | 1 |
| Duvoisin, RC | 1 |
3 reviews available for debrisoquin and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
The association between polymorphisms in the cytochrome P-450 2D6 gene and Parkinson's disease: a case-control study and meta-analysis.
Topics: Aged; Case-Control Studies; Cytochrome P-450 CYP2D6; Debrisoquin; Female; Genotype; Humans; Male; Pa | 1997 |
Liver enzyme abnormalities in Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; L | 1991 |
Abnormal liver enzyme-mediated metabolism in Parkinson's disease: a second look.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; L | 1991 |
2 trials available for debrisoquin and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Debrisoquine hydroxylation genotype in familial forms of idiopathic Parkinson's disease.
Topics: Aged; Base Sequence; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; DNA; Fema | 1996 |
Plasma HVA levels following debrisoquine administration do not reflect cerebral dopamine loss in early Parkinson's disease.
Topics: Adult; Aged; Biomarkers; Cerebral Cortex; Debrisoquin; Dopamine; Female; Homovanillic Acid; Humans; | 1994 |
16 other studies available for debrisoquin and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Debrisoquine hydroxylase gene polymorphism in Parkinson's disease and amyotrophic lateral sclerosis.
Topics: Acetyltransferases; Amyotrophic Lateral Sclerosis; Cytochrome P-450 Enzyme System; Debrisoquin; Geno | 1995 |
Genetic analysis of the CYP2D6 gene in patients with Parkinson's disease.
Topics: Alleles; Cytochrome P-450 CYP2D6; Debrisoquin; Deoxyribonucleases, Type II Site-Specific; Genotype; | 1998 |
Gene-toxin interaction as a putative risk factor for Parkinson's disease with dementia.
Topics: Aged; Apolipoproteins; Case-Control Studies; Comorbidity; Debrisoquin; Dementia; Environmental Expos | 1998 |
The sparteine/debrisoquine (CYP2D6) oxidation polymorphism and the risk of Parkinson's disease: a meta-analysis.
Topics: Aged; Case-Control Studies; Cohort Studies; Cytochrome P-450 CYP2D6; Debrisoquin; Genetic Heterogene | 1998 |
Debrisoquine metabolism in Chinese patients with Alzheimer's and Parkinson's diseases.
Topics: Aged; Alzheimer Disease; China; Debrisoquin; Female; Humans; Male; Oxidation-Reduction; Parkinson Di | 1992 |
Debrisoquine hydroxylation in Parkinson's disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; | 1992 |
Debrisoquine oxidation in Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin | 1991 |
[Hydroxylation of debrisoquin in Parkinson's disease].
Topics: Adult; Aged; Debrisoquin; Female; Humans; Hydroxylation; Isoquinolines; Male; Middle Aged; Parkinson | 1990 |
Poor hydroxylator phenotypes of debrisoquine and S-mephenytoin are not over-represented in a group of patients with Parkinson's disease.
Topics: Aged; Debrisoquin; Female; Humans; Hydroxylation; Male; Mephenytoin; Middle Aged; Parkinson Disease; | 1990 |
Metabolism and brain accumulation of tetrahydroisoquinoline (TIQ) a possible parkinsonism inducing substance, in an animal model of a poor debrisoquine metabolizer.
Topics: Animals; Brain; Chemical Phenomena; Chemistry; Debrisoquin; Disease Models, Animal; Female; Gas Chro | 1990 |
Oxidative polymorphism of debrisoquine in Parkinson's disease.
Topics: Adult; Aged; Debrisoquin; Female; Humans; Isoquinolines; Male; Middle Aged; Oxidation-Reduction; Par | 1990 |
Ecogenetics of Parkinson's disease: 4-hydroxylation of debrisoquine.
Topics: Adult; Aging; Debrisoquin; Female; Humans; Hydroxylation; Isoquinolines; Liver; Middle Aged; Parkins | 1985 |
Debrisoquine metabolism in parkinsonian patients treated with antihistamine drugs.
Topics: Debrisoquin; Drug Interactions; Histamine H1 Antagonists; Humans; Isoquinolines; Parkinson Disease | 1987 |
Susceptibility in Parkinson's disease. 'Of mice and men'.
Topics: Animals; Cytochrome P-450 Enzyme System; Debrisoquin; Free Radicals; Humans; Mice; Models, Biologica | 1988 |
Smoking, cancer, and Parkinson's disease.
Topics: Debrisoquin; Humans; Hydroxylation; Isoquinolines; Parkinson Disease; Phenotype; Smoking | 1987 |
Smoking, cancer, and Parkinson's disease.
Topics: Aged; Debrisoquin; Female; Humans; Hydroxylation; Isoquinolines; Kinetics; Male; Middle Aged; Neopla | 1986 |