debrisoquin has been researched along with Hypotension in 4 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Symptoms due to orthostatic and exertional hypotension occurred in 23-4 per cent of 448 hypertensive patients treated with guanethidine, debrisoquine, or bethanidine." | 3.65 | Factors predisposing to postural hypotensive symptoms in the treatment of high blood pressure. ( Smith, AJ; Talbot, S, 1975) |
| " Other reported effects are toxic confusional states and psychotic reactions." | 2.36 | Psychiatric side effects of antihypertensive drugs other than reserpine. ( Fleminger, R; Paykel, ES; Watson, JP, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| LURIA, MH | 1 |
| FREIS, ED | 1 |
| Paykel, ES | 1 |
| Fleminger, R | 1 |
| Watson, JP | 1 |
| Talbot, S | 2 |
| Smith, AJ | 1 |
| O'Malley, BC | 1 |
| Bing, RH | 1 |
1 review available for debrisoquin and Hypotension
| Article | Year |
|---|---|
Psychiatric side effects of antihypertensive drugs other than reserpine.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Anxiety; Bethanidine; Clonidine; Debrisoquin; | 1982 |
1 trial available for debrisoquin and Hypotension
| Article | Year |
|---|---|
Letter: Debrisoquine, guanethidine, and bethanidine in hypertension.
Topics: Antihypertensive Agents; Bethanidine; Debrisoquin; Diarrhea; Guanethidine; Guanidines; Humans; Hyper | 1975 |
2 other studies available for debrisoquin and Hypotension
| Article | Year |
|---|---|
TREATMENT OF HYPERTENSION WITH DEBRISOQUIN SULFATE (DECLINAX).
Topics: Antihypertensive Agents; Biomedical Research; Debrisoquin; Drug Therapy; Hydrochlorothiazide; Hypert | 1965 |
Factors predisposing to postural hypotensive symptoms in the treatment of high blood pressure.
Topics: Bethanidine; Cardiomegaly; Circadian Rhythm; Debrisoquin; Female; Guanethidine; Guanidines; Heart Ra | 1975 |