debrisoquin has been researched along with Hypotension, Postural in 8 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Symptoms due to orthostatic and exertional hypotension occurred in 23-4 per cent of 448 hypertensive patients treated with guanethidine, debrisoquine, or bethanidine." | 3.65 | Factors predisposing to postural hypotensive symptoms in the treatment of high blood pressure. ( Smith, AJ; Talbot, S, 1975) |
| " At the end of each study week, the steady-state pharmacokinetic parameters of nortriptyline or paroxetine were determined within the dose interval." | 2.70 | Inhibition of cytochrome P4502D6 activity with paroxetine normalizes the ultrarapid metabolizer phenotype as measured by nortriptyline pharmacokinetics and the debrisoquin test. ( Andersson, K; Bertilsson, L; Härtter, S; Laine, K; Svensson, JO; Tybring, G; Widén, J, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (87.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| LURIA, MH | 1 |
| FREIS, ED | 1 |
| Laine, K | 1 |
| Tybring, G | 1 |
| Härtter, S | 1 |
| Andersson, K | 1 |
| Svensson, JO | 1 |
| Widén, J | 1 |
| Bertilsson, L | 1 |
| Goldberg, AD | 1 |
| Raftery, EB | 1 |
| Sternon, J | 1 |
| Talbot, S | 2 |
| Smith, AJ | 1 |
| Gill, GW | 1 |
| Maas, JW | 1 |
| Contreras, SA | 1 |
| Bowden, CL | 1 |
| Weintraub, SE | 1 |
| Biron, P | 1 |
2 trials available for debrisoquin and Hypotension, Postural
| Article | Year |
|---|---|
Inhibition of cytochrome P4502D6 activity with paroxetine normalizes the ultrarapid metabolizer phenotype as measured by nortriptyline pharmacokinetics and the debrisoquin test.
Topics: Adult; Antidepressive Agents, Tricyclic; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors | 2001 |
Effects of debrisoquin on CSF and plasma HVA concentrations in man.
Topics: Adult; Aged; Debrisoquin; Homovanillic Acid; Humans; Hypotension, Orthostatic; Isoquinolines; Male; | 1985 |
6 other studies available for debrisoquin and Hypotension, Postural
| Article | Year |
|---|---|
TREATMENT OF HYPERTENSION WITH DEBRISOQUIN SULFATE (DECLINAX).
Topics: Antihypertensive Agents; Biomedical Research; Debrisoquin; Drug Therapy; Hydrochlorothiazide; Hypert | 1965 |
Patterns of blood-pressure during chronic administration of postganglionic sympathetic blocking drugs for hypertension.
Topics: Adult; Aged; Bethanidine; Blood Pressure; Circadian Rhythm; Debrisoquin; Female; Guanethidine; Guani | 1976 |
[The practitioner and drug-induced, predominantly orthostatic hypotension].
Topics: Adrenergic Agents; Adrenergic Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; A | 1978 |
Factors predisposing to postural hypotensive symptoms in the treatment of high blood pressure.
Topics: Bethanidine; Cardiomegaly; Circadian Rhythm; Debrisoquin; Female; Guanethidine; Guanidines; Heart Ra | 1975 |
Exertional hypotension due to postganglionic sympathetic blocking drugs.
Topics: Bethanidine; Blood Pressure; Debrisoquin; Guanethidine; Guanidines; Heart Rate; Humans; Hypotension, | 1976 |
[New sympathoplegic antihypersensive agent: debrisoquin sulfate].
Topics: Antihypertensive Agents; Debrisoquin; Humans; Hypertension; Hypotension, Orthostatic; Isoquinolines | 1973 |