debrisoquin has been researched along with Genetic Predisposition in 10 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Three examples of pharmacogenetic risk factors are discussed: the first two are p450 enzymes whose activity has been associated with susceptibility to lung cancer (debrisoquine hydroxylase, aryl hydrocarbon hydroxylase), and the last, N-acetyltransferase, a non-p450 enzyme, has been associated with bladder cancer susceptibility." | 3.68 | Study design and genetic susceptibility factors in the risk assessment of chemical carcinogens. ( Caporaso, N, 1991) |
| "The application of biomarkers to cancer epidemiology should enhance the validity of exposure and outcome measurement, and strengthen the statistical association between exposure and diseases, thus reducing the possibility of random and systematic error." | 1.29 | Sources of bias, effect of confounding in the application of biomarkers to epidemiological studies. ( Boffetta, P, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 9 (90.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vineis, P | 1 |
| Boffetta, P | 1 |
| Sinués, B | 1 |
| Rueda, P | 1 |
| Benítez, J | 2 |
| Saenz, MA | 1 |
| Bernal, ML | 1 |
| Lanuza, J | 1 |
| Alda, O | 1 |
| Tres, A | 1 |
| Bartolome, M | 1 |
| Barquero, MS | 1 |
| Coria, F | 1 |
| Molina, JA | 1 |
| Jiménez-Jiménez, FJ | 1 |
| Ladero, JM | 1 |
| Hubble, JP | 1 |
| Kurth, JH | 1 |
| Glatt, SL | 1 |
| Kurth, MC | 1 |
| Schellenberg, GD | 1 |
| Hassanein, RE | 1 |
| Lieberman, A | 1 |
| Koller, WC | 1 |
| Nebert, DW | 1 |
| Nikolov, IG | 1 |
| Chernozemsky, IN | 1 |
| Idle, JR | 1 |
| Caporaso, N | 2 |
| Gonzalez, FJ | 1 |
| Pickle, LW | 1 |
| Bale, S | 1 |
| Ayesh, R | 1 |
| Hetzel, M | 1 |
| Idle, J | 1 |
1 review available for debrisoquin and Genetic Predisposition
| Article | Year |
|---|---|
Hereditary polymorphisms of human drug metabolizing enzymes and cancer susceptibility.
Topics: Animals; Biotransformation; Carcinogens; Cytochrome P-450 Enzyme System; Debrisoquin; Genetic Predis | 1990 |
9 other studies available for debrisoquin and Genetic Predisposition
| Article | Year |
|---|---|
Use of biomarkers in epidemiology. The example of metabolic susceptibility to cancer.
Topics: Biomarkers; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Disease Susceptibi | 1995 |
Sources of bias, effect of confounding in the application of biomarkers to epidemiological studies.
Topics: Bias; Biomarkers; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Diagnostic E | 1995 |
Thioether excretion, urinary mutagenicity, and metabolic phenotype in smokers.
Topics: Acetylation; Adult; Biomarkers; Creatinine; Debrisoquin; Female; Genetic Predisposition to Disease; | 1994 |
Oxidative polymorphism of debrisoquine is not related to the risk of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Femal | 1993 |
Gene-toxin interaction as a putative risk factor for Parkinson's disease with dementia.
Topics: Aged; Apolipoproteins; Case-Control Studies; Comorbidity; Debrisoquin; Dementia; Environmental Expos | 1998 |
Identification of genetic differences in drug metabolism: prediction of individual risk of toxicity or cancer.
Topics: Alleles; Debrisoquin; Forecasting; Genes; Genetic Predisposition to Disease; Humans; Metabolism; Mut | 1991 |
Genetic predisposition to Balkan endemic nephropathy: ability to hydroxylate debrisoquine as a host risk factor.
Topics: Adult; Aged; Balkan Nephropathy; Bulgaria; Carcinoma, Transitional Cell; Case-Control Studies; Cytoc | 1991 |
Study design and genetic susceptibility factors in the risk assessment of chemical carcinogens.
Topics: Biotransformation; Carcinogens, Environmental; Case-Control Studies; Cytochrome P-450 CYP2D6; Cytoch | 1991 |
The distribution of debrisoquine metabolic phenotypes and implications for the suggested association with lung cancer risk.
Topics: Chromatography, Gas; Data Interpretation, Statistical; Debrisoquin; Gene Frequency; Genetic Predispo | 1989 |