debrisoquin has been researched along with Experimental Neoplasms in 1 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Antipyrine oxidation was increased in the cancerous state but the urinary metabolic profiles were similar in rats with cancer and in controls." | 1.28 | Drug metabolism in rats with cancer induced by N-nitrosodiethylamine and phenobarbital. ( Aitio, ML; Arvela, P; Bartsch, H; Béréziat, JC; Hietanen, E, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aitio, ML | 1 |
| Hietanen, E | 1 |
| Béréziat, JC | 1 |
| Arvela, P | 1 |
| Bartsch, H | 1 |
1 other study available for debrisoquin and Experimental Neoplasms
| Article | Year |
|---|---|
Drug metabolism in rats with cancer induced by N-nitrosodiethylamine and phenobarbital.
Topics: Animals; Antipyrine; Debrisoquin; Diethylnitrosamine; Liver; Male; Microsomes, Liver; Neoplasms, Exp | 1992 |