debrisoquin has been researched along with Diseases, Occupational in 4 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A report is given of a series of bladder cancer cases examined for the oxidation capacity demonstrated by the use of debrisoquine." | 7.67 | Genetically determined debrisoquine oxidation capacity in bladder cancer. ( Cartwright, RA; Glashan, RW; Philip, PA; Rogers, HJ, 1984) |
| "A report is given of a series of bladder cancer cases examined for the oxidation capacity demonstrated by the use of debrisoquine." | 3.67 | Genetically determined debrisoquine oxidation capacity in bladder cancer. ( Cartwright, RA; Glashan, RW; Philip, PA; Rogers, HJ, 1984) |
| "Debrisoquine phenotyping has potential for identifying carcinogen-exposed workers at high risk of lung cancer." | 1.28 | Lung cancer risk, occupational exposure, and the debrisoquine metabolic phenotype. ( Ayesh, R; Caporaso, N; Dosemeci, M; Hayes, RB; Hetzel, M; Hoover, R; Idle, J, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cartwright, RA | 1 |
| Philip, PA | 1 |
| Rogers, HJ | 1 |
| Glashan, RW | 1 |
| Black, C | 1 |
| May, G | 1 |
| Csuka, ME | 1 |
| Lupoli, S | 1 |
| Wilkinson, GR | 1 |
| Branch, RA | 1 |
| Caporaso, N | 1 |
| Hayes, RB | 1 |
| Dosemeci, M | 1 |
| Hoover, R | 1 |
| Ayesh, R | 1 |
| Hetzel, M | 1 |
| Idle, J | 1 |
| Omenn, GS | 1 |
1 review available for debrisoquin and Diseases, Occupational
| Article | Year |
|---|---|
Ethnic differences in reactions to drugs and xenobiotics. Susceptibility to occupational and environmental exposures to chemicals.
Topics: Acetylation; alpha 1-Antitrypsin; Anemia, Hemolytic; Aryl Hydrocarbon Hydroxylases; Asian People; Ba | 1986 |
3 other studies available for debrisoquin and Diseases, Occupational
| Article | Year |
|---|---|
Genetically determined debrisoquine oxidation capacity in bladder cancer.
Topics: Benzidines; Debrisoquin; Humans; Isoquinolines; Occupational Diseases; Oxidation-Reduction; Urinary | 1984 |
Activity of oxidative routes of metabolism of debrisoquin, mephenytoin, and dapsone is unrelated to the pathogenesis of vinyl chloride-induced disease.
Topics: Arylamine N-Acetyltransferase; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Humans; Male; M | 1992 |
Lung cancer risk, occupational exposure, and the debrisoquine metabolic phenotype.
Topics: Asbestos; Debrisoquin; Female; Humans; Isoquinolines; Lung Diseases, Obstructive; Lung Neoplasms; Ma | 1989 |