debrisoquin has been researched along with Diabetes Mellitus, Type 1 in 4 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Debrisoquine was administered orally and debrisoquine hydroxylation phenotype was determined as a metabolic ratio of urinary recovered debrisoquine and 4-hydroxydebrisoquine." | 1.32 | Altered distribution of the debrisoquine oxidative phenotypes in children with type 1 diabetes mellitus. ( Barkai, L; Krikovszky, D; Madácsy, L; Sánta, A, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Madácsy, L | 1 |
| Barkai, L | 1 |
| Sánta, A | 1 |
| Krikovszky, D | 1 |
| Kallio, J | 1 |
| Huupponen, R | 1 |
| Viikari, J | 1 |
| Hume, L | 1 |
| Bechtel, YC | 1 |
| Joanne, C | 1 |
| Grandmottet, M | 1 |
| Bechtel, PR | 1 |
4 other studies available for debrisoquin and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Altered distribution of the debrisoquine oxidative phenotypes in children with type 1 diabetes mellitus.
Topics: Case-Control Studies; Child; Child, Preschool; Cytochrome P-450 CYP2D6; Debrisoquin; Diabetes Mellit | 2004 |
Debrisoquine hydroxylation polymorphism in diabetic patients.
Topics: Adult; Blood Glucose; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Debrisoquin; Diabetes Mellitu | 1990 |
Potentiation of hypotensive effect of debrisoquine by insulin.
Topics: Adult; Antihypertensive Agents; Debrisoquin; Diabetes Mellitus, Type 1; Drug Synergism; Humans; Hype | 1985 |
The influence of insulin-dependent diabetes on the metabolism of caffeine and the expression of the debrisoquin oxidation phenotype.
Topics: Acetylation; Adult; Caffeine; Debrisoquin; Diabetes Mellitus, Type 1; Female; Humans; Isoquinolines; | 1988 |