debrisoquin has been researched along with Depressive Disorder in 13 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| " All patients were markedly improved when the daily dosage of the antidepressant was reduced with a simultaneous decrease of the blood concentrations." | 1.28 | High blood concentrations of imipramine or clomipramine and therapeutic failure: a case report study using drug monitoring data. ( Balant, LP; Balant-Gorgia, AE; Garrone, G, 1989) |
| "The debrisoquine-test appears to be a useful clinical tool for detecting in patients a genetic deficiency in the hydroxylation of AT-type drugs." | 1.27 | Amitriptyline pharmacokinetics and clinical response: II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin. ( Baumann, P; Jonzier-Perey, M; Koeb, L; Küpfer, A; Schöpf, J; Tinguely, D, 1986) |
| "(The debrisoquine test was performed after stopping NT treatment)." | 1.27 | Plasma concentrations of nortriptyline and its 10-hydroxy metabolite in depressed patients--relationship to the debrisoquine hydroxylation metabolic ratio. ( Benitez, J; Bertilsson, L; Nordin, C; Siwers, B, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (76.92) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Solai, LK | 1 |
| Pollock, BG | 1 |
| Mulsant, BH | 1 |
| Frye, RF | 1 |
| Miller, MD | 1 |
| Sweet, RA | 1 |
| Kirshner, M | 1 |
| Sorisio, D | 1 |
| Begley, A | 1 |
| Reynolds, CF | 1 |
| Bluhm, RE | 1 |
| Wilkinson, GR | 1 |
| Shelton, R | 1 |
| Branch, RA | 1 |
| Tacke, U | 1 |
| Leinonen, E | 1 |
| Lillsunde, P | 1 |
| Seppälä, T | 1 |
| Arvela, P | 1 |
| Pelkonen, O | 1 |
| Ylitalo, P | 1 |
| Derenne, F | 1 |
| Joanne, C | 1 |
| Vandel, S | 1 |
| Bertschy, G | 1 |
| Volmat, R | 1 |
| Bechtel, P | 1 |
| Balant-Gorgia, AE | 2 |
| Balant, LP | 1 |
| Garrone, G | 1 |
| Meyer, JW | 1 |
| Woggon, B | 2 |
| Küpfer, A | 2 |
| Baumann, P | 4 |
| Bosshart, P | 1 |
| Gabris, G | 1 |
| Gastpar, M | 1 |
| Koeb, L | 3 |
| Jonzier-Perey, M | 2 |
| Tinguely, D | 1 |
| Schöpf, J | 1 |
| Balant, L | 1 |
| Zysset, T | 1 |
| Nordin, C | 2 |
| Siwers, B | 1 |
| Benitez, J | 1 |
| Bertilsson, L | 2 |
| Schnyder, C | 1 |
| Wertheimer, J | 1 |
| Aberg-Wistedt, A | 1 |
| Gustafsson, LL | 1 |
2 trials available for debrisoquin and Depressive Disorder
| Article | Year |
|---|---|
Effect of nortriptyline and paroxetine on CYP2D6 activity in depressed elderly patients.
Topics: Adrenergic Agents; Aged; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; | 2002 |
[The use of low-dose amitriptyline in psychogeriatrics. A clinical, pharmacokinetic and pharmacogenetic study].
Topics: Aged; Amitriptyline; Debrisoquin; Depressive Disorder; Dose-Response Relationship, Drug; Female; Hum | 1985 |
11 other studies available for debrisoquin and Depressive Disorder
| Article | Year |
|---|---|
Genetically determined drug-metabolizing activity and desipramine-associated cardiotoxicity: a case report.
Topics: Acetylation; Debrisoquin; Depressive Disorder; Desipramine; Electrocardiography; Family; Genetic Tes | 1993 |
Debrisoquine hydroxylation phenotypes of patients with high versus low to normal serum antidepressant concentrations.
Topics: Antidepressive Agents; Chromatography, Gas; Cytochrome P-450 Enzyme System; Debrisoquin; Depressive | 1992 |
Debrisoquine oxidative phenotyping and psychiatric drug treatment.
Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Benzodiaz | 1989 |
High blood concentrations of imipramine or clomipramine and therapeutic failure: a case report study using drug monitoring data.
Topics: Aged; Clomipramine; Debrisoquin; Depressive Disorder; Female; Humans; Hydroxylation; Imipramine; Mid | 1989 |
Importance of oxidative polymorphism on clinical efficacy and side-effects of imipramine--a retrospective study.
Topics: Debrisoquin; Depressive Disorder; Female; Humans; Imipramine; Male; Mephenytoin; Middle Aged; Oxidat | 1988 |
Acetylation of maprotiline and desmethylmaprotiline in depressive patients phenotyped with sulfamidine, debrisoquine, and mephenytoin.
Topics: Acetylation; Anthracenes; Debrisoquin; Depressive Disorder; Gas Chromatography-Mass Spectrometry; Hu | 1988 |
Amitriptyline pharmacokinetics and clinical response: II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin.
Topics: Adult; Amitriptyline; Debrisoquin; Depressive Disorder; Female; Humans; Hydantoins; Hydroxylation; I | 1986 |
New aspects in research on blood levels and bioavailability of antidepressants.
Topics: Amitriptyline; Antidepressive Agents; Biological Availability; Debrisoquin; Depressive Disorder; Hum | 1986 |
High plasma concentrations of desmethylclomipramine after chronic administration of clomipramine to a poor metabolizer.
Topics: Allopurinol; Clomipramine; Debrisoquin; Depressive Disorder; Female; Humans; Hydroxylation; Kinetics | 1987 |
Plasma concentrations of nortriptyline and its 10-hydroxy metabolite in depressed patients--relationship to the debrisoquine hydroxylation metabolic ratio.
Topics: Debrisoquin; Depressive Disorder; Humans; Hydroxylation; Isoquinolines; Nortriptyline | 1985 |
Extremely rapid hydroxylation of debrisoquine: a case report with implication for treatment with nortriptyline and other tricyclic antidepressants.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Debrisoquin; Depressive Disorder; Drug Thera | 1985 |