debrisoquin has been researched along with Depression in 6 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with imipramine inhibited metabolism of both sparteine and debrisoquine (MR values about doubled), but did not affect the interpatient correlations." | 2.66 | Steady-state concentrations of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism. ( Bech, P; Bertilsson, L; Brøsen, K; Gram, LF; Klysner, R; Otton, SV, 1986) |
| " Other reported effects are toxic confusional states and psychotic reactions." | 2.36 | Psychiatric side effects of antihypertensive drugs other than reserpine. ( Fleminger, R; Paykel, ES; Watson, JP, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Paykel, ES | 1 |
| Fleminger, R | 1 |
| Watson, JP | 1 |
| Bertilsson, L | 2 |
| Aberg-Wistedt, A | 1 |
| Nielsen, KK | 1 |
| Brøsen, K | 2 |
| Gram, LF | 2 |
| Müller, N | 1 |
| Brockmöller, J | 1 |
| Roots, I | 1 |
| Balant-Gorgia, AE | 1 |
| Balant, LP | 1 |
| Genet, C | 1 |
| Dayer, P | 1 |
| Aeschlimann, JM | 1 |
| Garrone, G | 1 |
| Klysner, R | 1 |
| Otton, SV | 1 |
| Bech, P | 1 |
1 review available for debrisoquin and Depression
| Article | Year |
|---|---|
Psychiatric side effects of antihypertensive drugs other than reserpine.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Anxiety; Bethanidine; Clonidine; Debrisoquin; | 1982 |
2 trials available for debrisoquin and Depression
| Article | Year |
|---|---|
Steady-state plasma levels of clomipramine and its metabolites: impact of the sparteine/debrisoquine oxidation polymorphism. Danish University Antidepressant Group.
Topics: Adult; Aged; Clomipramine; Cytochrome P-450 Enzyme System; Debrisoquin; Depression; Female; Humans; | 1992 |
Steady-state concentrations of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism.
Topics: Adult; Aged; Aged, 80 and over; Clinical Trials as Topic; Debrisoquin; Depression; Desipramine; Fema | 1986 |
3 other studies available for debrisoquin and Depression
| Article | Year |
|---|---|
The debrisoquine hydroxylation test predicts steady-state plasma levels of desipramine.
Topics: Debrisoquin; Depression; Desipramine; Humans; Hydroxylation | 1983 |
Extremely long plasma half-life of amitriptyline in a woman with the cytochrome P450IID6 29/29-kilobase wild-type allele--a slowly reversible interaction with fluoxetine.
Topics: Alleles; Amitriptyline; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Debris | 1991 |
Importance of oxidative polymorphism and levomepromazine treatment on the steady-state blood concentrations of clomipramine and its major metabolites.
Topics: Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Benzodiazepines; Clomipramine; Debrisoquin; Dep | 1986 |