debrisoquin has been researched along with Chronic Illness in 5 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Determination of debrisoquine oxidation phenotype was carried out in 119 healthy subjects, 135 patients with chronic bronchitis and 153 patients with lung cancer, all of Caucasian origin." | 3.68 | Lack of a relationship between the polymorphism of debrisoquine oxidation and lung cancer. ( Barre, J; Bechtel, P; Brochard, P; Dalphin, JC; de Cremoux, H; Depierre, A; Duche, JC; Joanne, C; Tillement, JP, 1991) |
| "Perhexiline maleate is an antianginal agent which depends on hepatic oxidation for its elimination." | 1.27 | Impaired oxidation of debrisoquine in patients with perhexiline liver injury. ( Morgan, MY; Oates, NS; Reshef, R; Shah, RR; Sherlock, S; Smith, RL, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morgan, MY | 1 |
| Reshef, R | 1 |
| Shah, RR | 1 |
| Oates, NS | 1 |
| Smith, RL | 1 |
| Sherlock, S | 1 |
| Stanchev, A | 1 |
| Shishmanova, Iu | 1 |
| Sheĭtanov, I | 1 |
| Georgiev, I | 1 |
| Adi, FC | 1 |
| Eze, CJ | 1 |
| Anwunah, A | 1 |
| Duche, JC | 1 |
| Joanne, C | 1 |
| Barre, J | 1 |
| de Cremoux, H | 1 |
| Dalphin, JC | 1 |
| Depierre, A | 1 |
| Brochard, P | 1 |
| Tillement, JP | 1 |
| Bechtel, P | 1 |
| Bückert, A | 1 |
| Schweda, E | 1 |
| Vich, V | 1 |
2 trials available for debrisoquin and Chronic Illness
| Article | Year |
|---|---|
[Treatment of hypertension with the preparation Tendor].
Topics: Adult; Blood Pressure; Chronic Disease; Clinical Trials as Topic; Debrisoquin; Drug Evaluation; Fema | 1977 |
Comparison of debrisoquine and guanethidine in treatment of hypertension.
Topics: Administration, Oral; Adult; Body Weight; Chronic Disease; Debrisoquin; Economics, Medical; Ejaculat | 1975 |
3 other studies available for debrisoquin and Chronic Illness
| Article | Year |
|---|---|
Impaired oxidation of debrisoquine in patients with perhexiline liver injury.
Topics: Adolescent; Adult; Aged; Angina Pectoris; Chemical and Drug Induced Liver Injury; Chronic Disease; D | 1984 |
Lack of a relationship between the polymorphism of debrisoquine oxidation and lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Bronchitis; Chronic Disease; Debrisoquin; Female; Humans; Lung Neopl | 1991 |
[Therapeutic results with the hypotensive agent Declinax (debrisoquin) in mild and medium forms of hypertension].
Topics: Antihypertensive Agents; Blood Pressure; Chronic Disease; Debrisoquin; Diuretics; Drug Therapy, Comb | 1973 |