debrisoquin has been researched along with Chemical and Drug Induced Liver Injury in 5 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report on a case of perhexiline maleate-induced hepatitis secondary to a long-term administration of recommended daily dosages of 300 mg." | 1.28 | Perhexiline maleate-induced hepatitis. ( Maurer, R; Satz, N; Spycher, MA; Streuli, R; Täuber, M, 1991) |
| "Perhexiline maleate is an antianginal agent which depends on hepatic oxidation for its elimination." | 1.27 | Impaired oxidation of debrisoquine in patients with perhexiline liver injury. ( Morgan, MY; Oates, NS; Reshef, R; Shah, RR; Sherlock, S; Smith, RL, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Kenna, JG | 1 |
| Stahl, S | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Morgan, MY | 1 |
| Reshef, R | 1 |
| Shah, RR | 1 |
| Oates, NS | 1 |
| Smith, RL | 1 |
| Sherlock, S | 1 |
| Satz, N | 1 |
| Täuber, M | 1 |
| Streuli, R | 1 |
| Spycher, MA | 1 |
| Maurer, R | 1 |
| Toutoungi, M | 1 |
| Magnenat, D | 1 |
| Larrey, D | 1 |
| Henrion, J | 1 |
| Heller, F | 1 |
| Babany, G | 1 |
| Degott, C | 1 |
| Pessayre, D | 1 |
| Benhamou, JP | 1 |
5 other studies available for debrisoquin and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Impaired oxidation of debrisoquine in patients with perhexiline liver injury.
Topics: Adolescent; Adult; Aged; Angina Pectoris; Chemical and Drug Induced Liver Injury; Chronic Disease; D | 1984 |
Perhexiline maleate-induced hepatitis.
Topics: Angina Pectoris; Biopsy; Chemical and Drug Induced Liver Injury; Debrisoquin; Humans; Liver; Male; M | 1991 |
Lack of defect in oxidative hydroxylation of debrisoquine in a patient with halothane hepatitis.
Topics: Adult; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Syst | 1990 |
Metoprolol-induced hepatitis: rechallenge and drug oxidation phenotyping.
Topics: Chemical and Drug Induced Liver Injury; Debrisoquin; Female; Humans; Liver Function Tests; Metoprolo | 1988 |