debrisoquin has been researched along with Cardiac Hypertrophy in 2 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Cardiac Hypertrophy: Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Symptoms due to orthostatic and exertional hypotension occurred in 23-4 per cent of 448 hypertensive patients treated with guanethidine, debrisoquine, or bethanidine." | 3.65 | Factors predisposing to postural hypotensive symptoms in the treatment of high blood pressure. ( Smith, AJ; Talbot, S, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Talbot, S | 1 |
| Smith, AJ | 1 |
| Jackson, WB | 1 |
2 other studies available for debrisoquin and Cardiac Hypertrophy
| Article | Year |
|---|---|
Factors predisposing to postural hypotensive symptoms in the treatment of high blood pressure.
Topics: Bethanidine; Cardiomegaly; Circadian Rhythm; Debrisoquin; Female; Guanethidine; Guanidines; Heart Ra | 1975 |
Tolerance and side effects during long term treatment of hypertension with debrisoquine.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Cardiomegaly; Debrisoquin; Drug T | 1972 |