debrisoquin has been researched along with Carcinoma, Transitional Cell in 2 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Carcinoma, Transitional Cell: A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The oxidative polymorphism of debrisoquine has been determined in 125 patients with bladder cancer and in 556 healthy control subjects; 96." | 7.68 | Polymorphic oxidation of debrisoquine in bladder cancer. ( Benítez, J; Cobaleda, J; Fernández-Gundín, MJ; González-Rozas, F; Ladero, JM; Llerena, A; Martínez, C; Muñoz, JJ; Prados, J; Vargas, E, 1990) |
| "The oxidative polymorphism of debrisoquine has been determined in 125 patients with bladder cancer and in 556 healthy control subjects; 96." | 3.68 | Polymorphic oxidation of debrisoquine in bladder cancer. ( Benítez, J; Cobaleda, J; Fernández-Gundín, MJ; González-Rozas, F; Ladero, JM; Llerena, A; Martínez, C; Muñoz, JJ; Prados, J; Vargas, E, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nikolov, IG | 1 |
| Chernozemsky, IN | 1 |
| Idle, JR | 1 |
| Benítez, J | 1 |
| Ladero, JM | 1 |
| Fernández-Gundín, MJ | 1 |
| Llerena, A | 1 |
| Cobaleda, J | 1 |
| Martínez, C | 1 |
| Muñoz, JJ | 1 |
| Vargas, E | 1 |
| Prados, J | 1 |
| González-Rozas, F | 1 |
2 other studies available for debrisoquin and Carcinoma, Transitional Cell
| Article | Year |
|---|---|
Genetic predisposition to Balkan endemic nephropathy: ability to hydroxylate debrisoquine as a host risk factor.
Topics: Adult; Aged; Balkan Nephropathy; Bulgaria; Carcinoma, Transitional Cell; Case-Control Studies; Cytoc | 1991 |
Polymorphic oxidation of debrisoquine in bladder cancer.
Topics: Aged; Alcohol Drinking; Carcinoma, Transitional Cell; Debrisoquin; Female; Humans; Isoquinolines; Ma | 1990 |