debrisoquin has been researched along with Carcinoma, Bronchogenic in 2 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Carcinoma, Bronchogenic: Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Accordingly, two groups of cancer patients were investigated with debrisoquine, namely Nigerians with hepatocellular and related tumours and white smokers with bronchial carcinoma in the United Kingdom." | 1.26 | Population studies of polymorphism in drug oxidation and its relevance to carcinogenesis. ( Idle, JR; Ritchie, JC, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ritchie, JC | 1 |
| Idle, JR | 1 |
| Benítez, J | 1 |
| Ladero, JM | 1 |
| Jara, C | 1 |
| Carrillo, JA | 1 |
| Cobaleda, J | 1 |
| Llerena, A | 1 |
| Vargas, E | 1 |
| Muñoz, JJ | 1 |
2 other studies available for debrisoquin and Carcinoma, Bronchogenic
| Article | Year |
|---|---|
Population studies of polymorphism in drug oxidation and its relevance to carcinogenesis.
Topics: Animals; Biotransformation; Carcinoma, Bronchogenic; Debrisoquin; Humans; Isoquinolines; Lung Neopla | 1982 |
Polymorphic oxidation of debrisoquine in lung cancer patients.
Topics: Aged; Carcinoma, Bronchogenic; Debrisoquin; Female; Humans; Lung Neoplasms; Male; Middle Aged; Oxida | 1991 |