debrisoquin has been researched along with Breast Cancer in 3 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oxidative polymorphism of debrisoquine (DBQ) was determined in 98 women with breast cancer (mean age 59." | 7.68 | Polymorphic oxidation of debrisoquine in women with breast cancer. ( Benítez, J; Jara, C; Ladero, JM; Llerena, A; Muñoz, JJ; Valdivielso, MJ; Vargas, E, 1991) |
| "It was investigated whether breast cancer patients show a similar association with respect to the oxidative status of DEB." | 5.28 | Metabolism of debrisoquine and susceptibility to breast cancer. ( Bertram, B; Huober, J; Kaufmann, M; Petru, E; Schmähl, D, 1991) |
| "Oxidative polymorphism of debrisoquine (DBQ) was determined in 98 women with breast cancer (mean age 59." | 3.68 | Polymorphic oxidation of debrisoquine in women with breast cancer. ( Benítez, J; Jara, C; Ladero, JM; Llerena, A; Muñoz, JJ; Valdivielso, MJ; Vargas, E, 1991) |
| "129 female patients with breast cancer and 79 controls undergoing biopsy for benign breast conditions had debrisoquine hydroxylator phenotype established." | 3.68 | Cytochrome P450dbl phenotypes in malignant and benign breast disease. ( Fentiman, IS; Hamed, H; Idle, JR; Pontin, JE, 1990) |
| "It was investigated whether breast cancer patients show a similar association with respect to the oxidative status of DEB." | 1.28 | Metabolism of debrisoquine and susceptibility to breast cancer. ( Bertram, B; Huober, J; Kaufmann, M; Petru, E; Schmähl, D, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huober, J | 1 |
| Bertram, B | 1 |
| Petru, E | 1 |
| Kaufmann, M | 1 |
| Schmähl, D | 1 |
| Ladero, JM | 1 |
| Benítez, J | 1 |
| Jara, C | 1 |
| Llerena, A | 1 |
| Valdivielso, MJ | 1 |
| Muñoz, JJ | 1 |
| Vargas, E | 1 |
| Pontin, JE | 1 |
| Hamed, H | 1 |
| Fentiman, IS | 1 |
| Idle, JR | 1 |
3 other studies available for debrisoquin and Breast Cancer
| Article | Year |
|---|---|
Metabolism of debrisoquine and susceptibility to breast cancer.
Topics: Breast Neoplasms; Chromatography, High Pressure Liquid; Debrisoquin; Disease Susceptibility; Female; | 1991 |
Polymorphic oxidation of debrisoquine in women with breast cancer.
Topics: Adult; Aged; Breast Neoplasms; Debrisoquin; Female; Humans; Middle Aged; Oxidation-Reduction; Polymo | 1991 |
Cytochrome P450dbl phenotypes in malignant and benign breast disease.
Topics: Adult; Breast Diseases; Breast Neoplasms; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; D | 1990 |