debrisoquin has been researched along with Brain Injuries in 2 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gerstenbrand, F | 1 |
| Hackl, JM | 2 |
| Rumpl, E | 2 |
| Hörtnagl, H | 2 |
| Hammerle, AF | 1 |
| Brücke, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Controlling Hyperadrenergic Activity in Neurologic Injury[NCT01343329] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2011-07-31 | Withdrawn (stopped due to Unable to enroll subjects that fit study criteria.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for debrisoquin and Brain Injuries
| Article | Year |
|---|---|
[Use of a beta blocker in a traumatic apallic syndrome].
Topics: Adrenergic beta-Antagonists; Adult; Blood Glucose; Brain Injuries; Brain Stem; Coma; Debrisoquin; Dr | 1981 |
The activity of the sympathetic nervous system following severe head injury.
Topics: Adolescent; Adult; Brain Injuries; Debrisoquin; Electrocardiography; Epinephrine; Female; Heart Rate | 1980 |