debrisoquin and Blood Pressure, Low studies

debrisoquin and Blood Pressure, Low

Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.

Research Excerpts

Excerpt	Relevance	Reference
"Symptoms due to orthostatic and exertional hypotension occurred in 23-4 per cent of 448 hypertensive patients treated with guanethidine, debrisoquine, or bethanidine."	3.65	Factors predisposing to postural hypotensive symptoms in the treatment of high blood pressure. ( Smith, AJ; Talbot, S, 1975)
" Other reported effects are toxic confusional states and psychotic reactions."	2.36	Psychiatric side effects of antihypertensive drugs other than reserpine. ( Fleminger, R; Paykel, ES; Watson, JP, 1982)

Research

Studies (4)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (100.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

4 (100.00)

18.7374

1990's

0 (0.00)

18.2507

2000's

0 (0.00)

29.6817

2010's

0 (0.00)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
LURIA, MH	1
FREIS, ED	1
Paykel, ES	1
Fleminger, R	1
Watson, JP	1
Talbot, S	2
Smith, AJ	1
O'Malley, BC	1
Bing, RH	1

Studies

LURIA, MH

FREIS, ED

Paykel, ES

Fleminger, R

Watson, JP

Talbot, S

Smith, AJ

O'Malley, BC

Bing, RH

Reviews

1 review available for debrisoquin and Blood Pressure, Low

Article	Year
Psychiatric side effects of antihypertensive drugs other than reserpine. Journal of clinical psychopharmacology, 1982, Volume: 2, Issue:1 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Anxiety; Bethanidine; Clonidine; Debrisoquin;	1982

Article

Year

Psychiatric side effects of antihypertensive drugs other than reserpine.

Journal of clinical psychopharmacology, 1982, Volume: 2, Issue:1

Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Anxiety; Bethanidine; Clonidine; Debrisoquin;

1982

Trials

1 trial available for debrisoquin and Blood Pressure, Low

Article	Year
Letter: Debrisoquine, guanethidine, and bethanidine in hypertension. British medical journal, 1975, May-03, Volume: 2, Issue:5965 Topics: Antihypertensive Agents; Bethanidine; Debrisoquin; Diarrhea; Guanethidine; Guanidines; Humans; Hyper	1975

Article

Year

Letter: Debrisoquine, guanethidine, and bethanidine in hypertension.

British medical journal, 1975, May-03, Volume: 2, Issue:5965

Topics: Antihypertensive Agents; Bethanidine; Debrisoquin; Diarrhea; Guanethidine; Guanidines; Humans; Hyper

1975

Other Studies

2 other studies available for debrisoquin and Blood Pressure, Low

Article	Year
TREATMENT OF HYPERTENSION WITH DEBRISOQUIN SULFATE (DECLINAX). Current therapeutic research, clinical and experimental, 1965, Volume: 7 Topics: Antihypertensive Agents; Biomedical Research; Debrisoquin; Drug Therapy; Hydrochlorothiazide; Hypert	1965
Factors predisposing to postural hypotensive symptoms in the treatment of high blood pressure. British heart journal, 1975, Volume: 37, Issue:10 Topics: Bethanidine; Cardiomegaly; Circadian Rhythm; Debrisoquin; Female; Guanethidine; Guanidines; Heart Ra	1975

Article

Year

TREATMENT OF HYPERTENSION WITH DEBRISOQUIN SULFATE (DECLINAX).

Current therapeutic research, clinical and experimental, 1965, Volume: 7

Topics: Antihypertensive Agents; Biomedical Research; Debrisoquin; Drug Therapy; Hydrochlorothiazide; Hypert

1965

Factors predisposing to postural hypotensive symptoms in the treatment of high blood pressure.

British heart journal, 1975, Volume: 37, Issue:10

Topics: Bethanidine; Cardiomegaly; Circadian Rhythm; Debrisoquin; Female; Guanethidine; Guanidines; Heart Ra

1975