debrisoquin and Blood Pressure, High studies

Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.

Research Excerpts

Excerpt	Relevance	Reference
"Debrisoquine, an antihypertensive agent, was compared with methyldopa in a double-blind trial in the treatment of hypertension in 20 patients."	9.04	A comparison of debrisoquine and methyldopa in hypertension. ( Pörsti, P, 1976)
"The responsiveness of plasma aldosterone to the infusion of angiotensin II at dose rates of 2, 4, and 10 ng/kg X min was assessed in 11 normal subjects and 13 patients with mild essential hypertension before and after 4 weeks of treatment with the sympatholytic agent debrisoquine."	7.67	Relationship between plasma aldosterone and angiotensin II before and after noradrenergic inhibition in normal subjects and patients with mild essential hypertension. ( Beretta-Piccoli, C; Bianchetti, MG; Boehringer, K; Link, L; Morton, JJ; Weidmann, P, 1984)
" The study was conducted on 10 patients of both sexes with mild to severe essential hypertension, aged 28 to 76 years, with normal hepatic and renal function and phenotyped as extensive metabolizers of debrisoquine (urine debrisoquine to 4-hydroxydebrisoquine ratios of 0."	5.09	Enantioselectivity in the steady-state pharmacokinetics of metoprolol in hypertensive patients. ( Cerqueira, PM; Cesarino, EJ; Lanchote, VL; Mateus, FH; Mere, Y; Santos, SR, 1999)
"A possible modulating influence of noradrenergic activity on serum lipoproteins was assessed under placebo conditions and following 4 weeks of sympathetic neurone blockade with debrisoquine in 9 normal subjects, 11 patients with mild essential hypertension, 9 normotensive, and 9 hypertensive hemodialysis patients."	5.06	Association between sympathetic activity and the atherogenic serum cholesterol fraction. ( Beretta-Piccoli, C; Ferrari, P; Jahn, HA; Riesen, W; Schohn, DC; Shaw, SG; Weidmann, P, 1990)
"Debrisoquine, an antihypertensive agent, was compared with methyldopa in a double-blind trial in the treatment of hypertension in 20 patients."	5.04	A comparison of debrisoquine and methyldopa in hypertension. ( Pörsti, P, 1976)
"The responsiveness of plasma aldosterone to the infusion of angiotensin II at dose rates of 2, 4, and 10 ng/kg X min was assessed in 11 normal subjects and 13 patients with mild essential hypertension before and after 4 weeks of treatment with the sympatholytic agent debrisoquine."	3.67	Relationship between plasma aldosterone and angiotensin II before and after noradrenergic inhibition in normal subjects and patients with mild essential hypertension. ( Beretta-Piccoli, C; Bianchetti, MG; Boehringer, K; Link, L; Morton, JJ; Weidmann, P, 1984)
"Symptoms due to orthostatic and exertional hypotension occurred in 23-4 per cent of 448 hypertensive patients treated with guanethidine, debrisoquine, or bethanidine."	3.65	Factors predisposing to postural hypotensive symptoms in the treatment of high blood pressure. ( Smith, AJ; Talbot, S, 1975)
"The influence of chronic renal failure on the stereoselective metabolism of rac-metoprolol was investigated in 15 hypertensive patients, 7 of them with chronic renal failure and 8 with normal renal function."	2.71	Influence of chronic renal failure on stereoselective metoprolol metabolism in hypertensive patients. ( Cerqueira, PM; Coelho, EB; Geleilete, TJ; Goldman, GH; Lanchote, VL, 2005)
"Where practicable, all subjects found with onset-phase-four blood pressure of 90 mmHg or more after referral were allocated, on a random basis, to alternative antihypertensive regimes at a dosage related to response."	2.64	An approach to realistic evaluation of antihypertensive regimes. ( Akinkugbe, OO; Basile, U; Carlisle, R; Solagbade, ME, 1977)
"Essential hypertension is the most important cardiovascular disease in black subjects."	2.36	The relative importance of genetic and environmental factors in hypertension in black subjects. ( Aderounmu, AF, 1981)
" If standard doses of some beta-blockers are used in poor metabolizers, these patients may be susceptible to concentration-related adverse reactions and they may also require lower and less frequent dosing for control of angina pectoris."	1.27	Debrisoquine polymorphism and the metabolism and action of metoprolol, timolol, propranolol and atenolol. ( Lennard, MS; Silas, JH; Tucker, GT; Woods, HF, 1986)
" No significant differences between the two phenotypes were observed in either the area under the plasma prazosin concentration-time curve, the terminal half-life or the first-dose effect of prazosin."	1.27	Lack of relationship between debrisoquine oxidation phenotype and the pharmacokinetics and first dose effect of prazosin. ( Lennard, MS; McGourty, JC; Silas, JH, 1988)

Research

Studies (62)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Change in Ambulatory Diastolic Blood Pressure

Timeframe	Studies, this research(%)	All Research%
pre-1990	57 (91.94)	18.7374
1990's	2 (3.23)	18.2507
2000's	3 (4.84)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Schlaich, MP	1
Socratous, F	1
Hennebry, S	1
Eikelis, N	1
Lambert, EA	1
Straznicky, N	1
Esler, MD	1
Lambert, GW	1
LURIA, MH	1
FREIS, ED	1
Cerqueira, PM	3
Coelho, EB	1
Geleilete, TJ	1
Goldman, GH	1
Lanchote, VL	3
French, AJ	1
Patel, YV	1
Aderounmu, AF	1
Avigdor, L	2
Waeber, B	3
Brunner, HR	3
Beretta-Piccoli, C	4
Weidmann, P	6
Boehringer, K	1
Link, L	1
Bianchetti, MG	1
Morton, JJ	1
Szebeni, A	1
Silas, JH	5
Tucker, GT	4
Smith, AJ	5
Fieller, NR	1
Seedat, YK	1
Grimm, M	1
Meier, A	1
Glück, Z	2
Keusch, G	2
Minder, I	1
Cesarino, EJ	2
Mateus, FH	2
Mere, Y	1
Santos, SR	1
Bonato, PS	1
Harvald, B	1
Schaumburg, E	1
Turner, R	1
White, P	1
Benton, F	1
Talbot, S	3
Khattri, HN	1
Wahi, PL	1
Ferguson, RK	1
Turini, GA	1
Gavras, H	1
Goldberg, AD	1
Raftery, EB	1
Stanchev, A	1
Shishmanova, Iu	1
Sheĭtanov, I	1
Georgiev, I	1
Myers, MG	1
Aminu, J	1
Vere, DW	1
Flammer, J	2
Ziegler, WH	2
Reubi, FC	2
Mérier, GR	1
Baczko, A	1
Lennard, MS	4
Malcolm, SL	2
Marten, TR	2
Böszörményi, E	1
Farsang, C	1
Morvai, V	1
Pörsti, P	1
Carlisle, R	2
Akinkugbe, OO	2
Basile, U	1
Solagbade, ME	1
Olatunde, A	1
Bailey, RR	1
Perret, L	1
Adi, FC	1
Eze, CJ	1
Anwunah, A	1
O'Malley, BC	1
Bing, RH	1
Pincus, R	1
Angelo, M	1
Dring, LG	1
Lancaster, R	1
Latham, A	1
Smith, RL	1
Pozenel, H	1
Schohn, DC	1
Riesen, W	1
Jahn, HA	1
Ferrari, P	1
Shaw, SG	1
Woods, HF	1
Hume, L	1
McGourty, JC	1
Magro, AM	1
Rudofsky, UH	1
Gilboa, N	1
Seegal, R	1
Schohn, D	1
Jahn, H	1
Jackson, WB	1
Vorburger, C	1
Tuckman, J	1
Simpson, FO	1
Hamilton, M	1
Bückert, A	1
Schweda, E	1
Vich, V	1
Laverty, R	1
O'Brien, BW	1
Langer, L	1
Gerö, A	1
Garrick, R	1
Ewan, CE	1
Bauer, GE	1
Neale, FC	1
Cohen, SL	1
Ocon Pujadas, J	1
Biron, P	1
Honorato, F	1
Ortolá, RP	1

Trial	Enrollment	Study Type	Start Date	Status
Impact of Renal SympAthetic DenerVation on Chronic HypErtension[NCT01628198]	38 participants (Actual)	Interventional	2011-10-31	Terminated (stopped due to recommendation by the study's DSMB due to insufficient data to determine efficacy.)
Renal Sympathetic Denervation for the Management of Chronic Hypertension[NCT01628172]	96 participants (Actual)	Interventional	2011-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The change in diastolic blood pressure as measured by 24 hour ambulatory monitoring at 6 months as compared to from baseline. (NCT01628198)
Timeframe: baseline and 6 months

Mean Change in Ambulatory Systolic Blood Pressure

Intervention	mmHg mean change (Mean)
Renal Denervation Group	-5.5

The change in systolic blood pressure as measured by 24 hour ambulatory monitoring at 6 months as compared to from baseline. (NCT01628198)
Timeframe: baseline and 6 months

Anti-hypertensive Medications

Intervention	mmHg (Mean)
Renal Denervation Group	-10.2

The total number of anti-hypertensive medications at baseline, 6 months, and 12 months (NCT01628198)
Timeframe: Baseline, 6 months, 12 months

Blood Urea Nitrogen

Intervention	medications (Mean)
	Baseline	6 months	12 months
Renal Denervation Group	5.37	4.79	4.64

A blood urea nitrogen (BUN) test measures the amount of nitrogen in blood that comes from the waste product urea. Urea is made when protein is broken down in the body. Urea is made in the liver and passed out in the urine. (NCT01628198)
Timeframe: baseline, 6 months, 12 months

Creatinine

Intervention	mg/dL (Mean)
	Baseline	6 months	12 months
Renal Denervation Group	20.82	22.15	23.11

Creatinine measures the level of the waste product in the body. The amount of creatinine in the blood depends partly on the amount of muscle tissue you have. Men generally have higher creatinine levels than women.Normal levels of creatinine in the blood are approximately 0.6 to 1.2 milligrams (mg) per deciliter (dL) in adult males and 0.5 to 1.1 milligrams per deciliter in adult females. High levels of creatinine indicates kidney impairment. (NCT01628198)
Timeframe: baseline, 6 months, 12 months

Office Diastolic BP

Intervention	mg/dl (Mean)
	Baseline	6 months	12 months
Renal Denervation Group	1.6	1.68	2.03

Different time points office diastolic blood pressure measurements (NCT01628198)
Timeframe: baseline, 6 month, 12 months

Office Systolic BP

Intervention	mm Hg (Mean)
	Baseline	6 months	12 months
Renal Denervation Group	87.06	86.93	87.75

Different time points office systolic blood pressure measurements (NCT01628198)
Timeframe: baseline, 6 month, 12 months

Renal Aortic Ratio

Intervention	mm Hg (Mean)
	Baseline	6 months	12 months
Renal Denervation Group	156.86	151.19	158.45

Renal artery blood flow as measured by Renal Aortic Ratio (RAR) = Peak systolic Velocity renal artery / Peak Systolic Velocity Aorta. A >60% stenosis is reported when there is a >3.5:1 Renal to Aortic Ratio. (NCT01628198)
Timeframe: Baseline and 12 months

Renal Artery Dimensions

Intervention	ratio (Mean)
	Baseline Right RAR	Baseline Left RAR	12 months Right RAR	12 months Left RAR
Renal Denervation Group	1.38	1.52	1.41	1.52

Dimensions of renal artery, right and left (NCT01628198)
Timeframe: baseline and 12 months

Resistive Index

Intervention	mm (Mean)
	Baseline R Kidney	Baseline L Kidney	12 months R Kidney	12 months L Kidney
Renal Denervation Group	11.43	11.68	11.26	11.39

Renal artery blood flow as measured by Resistive Index. RI = (peak systolic velocity - end diastolic velocity ) / peak systolic velocity. the normal value is ~ 0.60, with 0.70 being around the upper limits of normal (NCT01628198)
Timeframe: Baseline and 12 months

Intervention	index (Mean)
	Baseline Right RI	Baseline Left RI	12 months Right RI	12 months Left RI
Renal Denervation Group	0.67	0.72	0.72	0.72

Article	Year
Sympathetic activation in chronic renal failure. Journal of the American Society of Nephrology : JASN, 2009, Volume: 20, Issue:5 Topics: Animals; Cardiovascular Diseases; Catecholamines; Clonidine; Debrisoquin; Disease Models, Animal; Ef	2009
Sympathetic activation in chronic renal failure. Journal of the American Society of Nephrology : JASN, 2009, Volume: 20, Issue:5 Topics: Animals; Cardiovascular Diseases; Catecholamines; Clonidine; Debrisoquin; Disease Models, Animal; Ef	2009
Sympathetic activation in chronic renal failure. Journal of the American Society of Nephrology : JASN, 2009, Volume: 20, Issue:5 Topics: Animals; Cardiovascular Diseases; Catecholamines; Clonidine; Debrisoquin; Disease Models, Animal; Ef	2009
Sympathetic activation in chronic renal failure. Journal of the American Society of Nephrology : JASN, 2009, Volume: 20, Issue:5 Topics: Animals; Cardiovascular Diseases; Catecholamines; Clonidine; Debrisoquin; Disease Models, Animal; Ef	2009
The relative importance of genetic and environmental factors in hypertension in black subjects. Clinical and experimental hypertension, 1981, Volume: 3, Issue:4 Topics: Adrenergic beta-Antagonists; Africa; Antihypertensive Agents; Black or African American; Black Peopl	1981
New drugs in hypertension. Canadian Medical Association journal, 1977, Jan-22, Volume: 116, Issue:2 Topics: Antihypertensive Agents; Bethanidine; Clonidine; Debrisoquin; Female; Humans; Hypertension; Male; Pr	1977
Combination antihypertensive therapy. Cardiovascular clinics, 1971, Volume: 2, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amphetamine; Antidepressive Agents; Antih	1971
The mechanisms of action of some antihypertensive drugs. British medical bulletin, 1973, Volume: 29, Issue:2 Topics: Animals; Antihypertensive Agents; Brain; Bretylium Compounds; Clonidine; Debrisoquin; Diuretics; Gua	1973

Article	Year
Influence of chronic renal failure on stereoselective metoprolol metabolism in hypertensive patients. Journal of clinical pharmacology, 2005, Volume: 45, Issue:12 Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Cytochrome P-450 CYP2D6; Debrisoquin; F	2005
[Evaluation by practicing physicians of the antihypertensive efficacy of debrisoquin, methyldopa and propranolol]. Schweizerische medizinische Wochenschrift, 1983, Mar-05, Volume: 113, Issue:9 Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Debrisoquin; Female; Heart Rate; Humans; Hype	1983
Accumulation of debrisoquine by platelets in vivo: a model of events at the peripheral adrenergic neurone. British journal of clinical pharmacology, 1980, Volume: 9, Issue:4 Topics: Amitriptyline; Blood Platelets; Debrisoquin; Erythrocytes; Humans; Hydroxylation; Hypertension; Isoq	1980
An evaluation of debrisoquine and mefruside in the treatment of hypertension in African and Indian patients. Current medical research and opinion, 1980, Volume: 7, Issue:1 Topics: Adult; Aged; Debrisoquin; Diuretics; Double-Blind Method; Drug Combinations; Drug Evaluation; Female	1980
Enantioselectivity in the steady-state pharmacokinetics of metoprolol in hypertensive patients. Chirality, 1999, Volume: 11, Issue:7 Topics: Adult; Aged; Antihypertensive Agents; Area Under Curve; Debrisoquin; Female; Half-Life; Humans; Hype	1999
Enantioselectivity of debrisoquine 4-hydroxylation in Brazilian Caucasian hypertensive patients phenotyped as extensive metabolizers. Journal of chromatography. B, Biomedical sciences and applications, 2000, Dec-01, Volume: 749, Issue:2 Topics: Adult; Aged; Antihypertensive Agents; Brazil; Calibration; Chromatography, High Pressure Liquid; Deb	2000
The position of beta-blockers in antihypertensive therapy. Comparison with other antihypertensive agents. Cardiology, 1979, Volume: 64 Suppl 1 Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials a	1979
[Treatment of hypertension with the preparation Tendor]. Vutreshni bolesti, 1977, Volume: 16, Issue:6 Topics: Adult; Blood Pressure; Chronic Disease; Clinical Trials as Topic; Debrisoquin; Drug Evaluation; Fema	1977
A longitudinal study of the mechanisms of action of debrisoquine and propranolol. British journal of clinical pharmacology, 1978, Volume: 6, Issue:1 Topics: Adult; Blood Pressure; Clinical Trials as Topic; Debrisoquin; Double-Blind Method; Female; Humans; H	1978
[Clinical assay of a debrisoquine-diuretic compound when treating moderate arterial hypertension (author's transl)]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1979, Aug-28, Volume: 68, Issue:35 Topics: Adult; Aged; Debrisoquin; Diuretics; Drug Combinations; Drug Evaluation; Female; Humans; Hypertensio	1979
A comparison of debrisoquine and methyldopa in hypertension. Annals of clinical research, 1976, Volume: 8, Issue:1 Topics: Adult; Clinical Trials as Topic; Debrisoquin; Female; Humans; Hydrochlorothiazide; Hypertension; Iso	1976
An approach to realistic evaluation of antihypertensive regimes. Postgraduate medical journal, 1977, Volume: 53, Issue:615 Topics: Adult; Antihypertensive Agents; Community Medicine; Debrisoquin; Female; Guanethidine; Humans; Hyper	1977
[Antihypertensive action of debrisoquine (author's transl)]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1975, May-27, Volume: 64, Issue:21 Topics: Clinical Trials as Topic; Debrisoquin; Drug Evaluation; Humans; Hypertension; Isoquinolines	1975
Comparison of debrisoquine and guanethidine in treatment of hypertension. British medical journal, 1975, Mar-01, Volume: 1, Issue:5956 Topics: Administration, Oral; Adult; Body Weight; Chronic Disease; Debrisoquin; Economics, Medical; Ejaculat	1975
Letter: Debrisoquine, guanethidine, and bethanidine in hypertension. British medical journal, 1975, May-03, Volume: 2, Issue:5965 Topics: Antihypertensive Agents; Bethanidine; Debrisoquin; Diarrhea; Guanethidine; Guanidines; Humans; Hyper	1975
Association between sympathetic activity and the atherogenic serum cholesterol fraction. Klinische Wochenschrift, 1990, Mar-05, Volume: 68, Issue:5 Topics: Adult; Arteriosclerosis; Blood Pressure; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholestero	1990
Control of moderately raised blood pressure. Report of a co-operative randomized controlled trial. British medical journal, 1973, Aug-25, Volume: 3, Issue:5877 Topics: Aged; Antihypertensive Agents; Bendroflumethiazide; Blood Pressure; Cardiovascular Diseases; Clinica	1973

Article	Year
TREATMENT OF HYPERTENSION WITH DEBRISOQUIN SULFATE (DECLINAX). Current therapeutic research, clinical and experimental, 1965, Volume: 7 Topics: Antihypertensive Agents; Biomedical Research; Debrisoquin; Drug Therapy; Hydrochlorothiazide; Hypert	1965
Total ischaemia at site of local anaesthesia in patient on debrisoquine. Lancet (London, England), 1980, Aug-30, Volume: 2, Issue:8192 Topics: Anesthesia, Local; Debrisoquin; Female; Humans; Hypertension; Ischemia; Isoquinolines; Skin	1980
Long-term follow-up study of hypertensive patients by practicing internists after a controlled drug trial. Clinical therapeutics, 1984, Volume: 6, Issue:4 Topics: Antihypertensive Agents; Blood Pressure; Debrisoquin; Double-Blind Method; Drug Therapy, Combination	1984
Relationship between plasma aldosterone and angiotensin II before and after noradrenergic inhibition in normal subjects and patients with mild essential hypertension. The Journal of clinical endocrinology and metabolism, 1984, Volume: 59, Issue:2 Topics: Adult; Aged; Aldosterone; Angiotensin II; Blood Pressure; Debrisoquin; Female; Humans; Hypertension;	1984
Experiences with Tendor in geriatric patients. Therapia Hungarica (English edition), 1980, Volume: 28, Issue:3 Topics: Age Factors; Aged; Debrisoquin; Female; Humans; Hypertension; Isoquinolines; Male; Middle Aged	1980
Pathogenic and therapeutic significance of cardiovascular pressor reactivity as related to plasma catecholamines in borderline and established essential hypertension. Clinical and experimental hypertension, 1980, Volume: 2, Issue:3-4 Topics: Adult; Blood Pressure; Debrisoquin; Diuretics; Dose-Response Relationship, Drug; Humans; Hypertensio	1980
[Debrisoquin as a part of combined antihypertensive therapy]. Ugeskrift for laeger, 1976, Feb-09, Volume: 138, Issue:7 Topics: Adrenergic beta-Antagonists; Benzothiadiazines; Debrisoquin; Diuretics; Drug Therapy, Combination; F	1976
The management of hypertension with special reference to debrisoquine and beta blockade. The Practitioner, 1976, Volume: 216, Issue:1294 Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Debrisoquin; Diuretics; Female; Humans; Hy	1976
Angina in hypertensive patients. With particular reference to the negative chronotropic effects of sympatholytic therapy. Cardiology, 1976, Volume: 61, Issue:4 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Bethanidine; Blood Pressure; Debrisoquin; Drug Therapy	1976
Drug treatment of hypertension. Indian heart journal: teaching series, 1976, Volume: 1, Issue:1 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Debrisoquin; Diazoxide; Diuretics; Female; Hum	1976
Editorial: Adrenergic-neuron and beta-receptor blockade in hypertension. Lancet (London, England), 1976, May-15, Volume: 1, Issue:7968 Topics: Antihypertensive Agents; Debrisoquin; Drug Evaluation; Drug Therapy, Combination; Humans; Hypertensi	1976
Patterns of blood-pressure during chronic administration of postganglionic sympathetic blocking drugs for hypertension. Lancet (London, England), 1976, Nov-13, Volume: 2, Issue:7994 Topics: Adult; Aged; Bethanidine; Blood Pressure; Circadian Rhythm; Debrisoquin; Female; Guanethidine; Guani	1976
Factors predisposing to postural hypotensive symptoms in the treatment of high blood pressure. British heart journal, 1975, Volume: 37, Issue:10 Topics: Bethanidine; Cardiomegaly; Circadian Rhythm; Debrisoquin; Female; Guanethidine; Guanidines; Heart Ra	1975
Management of hypertension. The Practitioner, 1975, Volume: 215, Issue:1287 Topics: Adrenergic beta-Antagonists; Age Factors; Bethanidine; Clonidine; Debrisoquin; Decision Making; Diur	1975
Cardiovascular and endocrine profile of adrenergic neurone blockade in normal and hypertensive man. The American journal of medicine, 1979, Volume: 66, Issue:1 Topics: Adult; Aged; Aldosterone; Blood Pressure; Blood Volume; Body Weight; Debrisoquin; Female; Hemodynami	1979
Increased ratio between changes in blood pressure and plasma norepinephrine in essential hypertension. The Journal of clinical endocrinology and metabolism, 1979, Volume: 48, Issue:5 Topics: Blood Pressure; Debrisoquin; Humans; Hypertension; Norepinephrine; Renin	1979
The disposition of debrisoquine in hypertensive patients. British journal of clinical pharmacology, 1978, Volume: 5, Issue:1 Topics: Adult; Blood Pressure; Debrisoquin; Drug Administration Schedule; Food; Humans; Hypertension; Isoqui	1978
Clinical observation with debrisoquinsulphate (Tendor) in essential hypertension and glomerulonephritis. Therapia Hungarica (English edition), 1978, Volume: 26, Issue:2 Topics: Adult; Aged; Debrisoquin; Female; Glomerulonephritis; Humans; Hypertension; Isoquinolines; Male; Mid	1978
Why hypertensive patients vary in their response to oral debrisoquine. British medical journal, 1977, Feb-12, Volume: 1, Issue:6058 Topics: Administration, Oral; Blood Pressure; Debrisoquin; Dose-Response Relationship, Drug; Hypertension; I	1977
Beta-adrenergic blockers in the treatment of hypertension--experience with propranolol at Ibadan, Nigeria. East African medical journal, 1977, Volume: 54, Issue:4 Topics: Adult; Aged; Debrisoquin; Drug Therapy, Combination; Female; Humans; Hydroflumethiazide; Hypertensio	1977
Antagonism of debrisoquine sulfate by pizotifen (Sandomigran) The New Zealand medical journal, 1976, Jun-23, Volume: 83, Issue:566 Topics: Adult; Debrisoquin; Humans; Hypertension; Isoquinolines; Male; Pizotyline; Thiophenes	1976
Letter: Are beta blockers better? The Medical journal of Australia, 1975, Sep-20, Volume: 2, Issue:12 Topics: Debrisoquin; Female; Humans; Hypertension; Methyldopa; Propranolol	1975
Proceedings: A correlation between the response to debrisoquine and the amount of unchanged drug excreted in the urine. British journal of pharmacology, 1975, Volume: 55, Issue:2 Topics: Blood Pressure; Debrisoquin; Humans; Hydroxylation; Hypertension; Isoquinolines	1975
[The submaximal ergometric load test in hypertensive patients during physical training and treatment with debrisoquin (author's transl)]. Wiener klinische Wochenschrift, 1975, Nov-28, Volume: 87, Issue:22 Topics: Balneology; Blood Pressure; Debrisoquin; Female; Humans; Hypertension; Isoquinolines; Male; Middle A	1975
Debrisoquine polymorphism and the metabolism and action of metoprolol, timolol, propranolol and atenolol. Xenobiotica; the fate of foreign compounds in biological systems, 1986, Volume: 16, Issue:5 Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Debrisoquin; Genetic Variation; Humans; Hypertension;	1986
Potentiation of hypotensive effect of debrisoquine by insulin. Diabetic medicine : a journal of the British Diabetic Association, 1985, Volume: 2, Issue:5 Topics: Adult; Antihypertensive Agents; Debrisoquin; Diabetes Mellitus, Type 1; Drug Synergism; Humans; Hype	1985
Lack of relationship between debrisoquine oxidation phenotype and the pharmacokinetics and first dose effect of prazosin. British journal of clinical pharmacology, 1988, Volume: 25, Issue:2 Topics: Blood Pressure; Debrisoquin; Female; Half-Life; Humans; Hypertension; Isoquinolines; Male; Middle Ag	1988
Increased catecholamine output in the hypertensive fawn-hooded rat. Laboratory animal science, 1986, Volume: 36, Issue:6 Topics: Animals; Blood Pressure; Debrisoquin; Dopamine; Homovanillic Acid; Hypertension; Norepinephrine; Rat	1986
Norepinephrine-related mechanism in hypertension accompanying renal failure. Kidney international, 1985, Volume: 28, Issue:5 Topics: Adult; Aged; Angiotensin II; Blood Pressure; Blood Volume; Debrisoquin; Female; Heart Rate; Humans;	1985
Tolerance and side effects during long term treatment of hypertension with debrisoquine. Australian and New Zealand journal of medicine, 1972, Volume: 2, Issue:4 Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Cardiomegaly; Debrisoquin; Drug T	1972
[New antihypertensive drugs]. Schweizerische medizinische Wochenschrift, 1972, Jul-29, Volume: 102, Issue:30 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Clonidine; Clopamide; Debrisoquin; Drug Synerg	1972
Hypertension. The Practitioner, 1974, Volume: 213, Issue:1276 SPEC Topics: Adrenergic beta-Antagonists; Aortic Diseases; Benzothiadiazines; Brain Diseases; Cerebrovascular Dis	1974
[Therapeutic results with the hypotensive agent Declinax (debrisoquin) in mild and medium forms of hypertension]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1973, Nov-20, Volume: 62, Issue:47 Topics: Antihypertensive Agents; Blood Pressure; Chronic Disease; Debrisoquin; Diuretics; Drug Therapy, Comb	1973
The management of essential hypertension. JAMA, 1974, Aug-05, Volume: 229, Issue:6 Topics: Antihypertensive Agents; Benzyl Compounds; Debrisoquin; Diazoxide; Diuretics; Guanidines; Humans; Hy	1974
Clinical trials with Tendor (debrisoquine sulfate). Therapia Hungarica (English edition), 1974, Volume: 22, Issue:4 Topics: Aged; Antihypertensive Agents; Blood Pressure; Debrisoquin; Drug Therapy, Combination; Drug Toleranc	1974
Serum uric acid in normal and hypertensive Australian subjects. Australian and New Zealand journal of medicine, 1972, Volume: 2, Issue:4 Topics: Adolescent; Adult; Age Factors; Australia; Child; Colorimetry; Debrisoquin; Female; Guanethidine; Hu	1972
Hypertension in renal transplant recipients: role of bilateral nephrectomy. British medical journal, 1973, Jul-14, Volume: 3, Issue:5871 Topics: Blood Pressure; Creatinine; Debrisoquin; Humans; Hypertension; Kidney Function Tests; Kidney Transpl	1973
[Clinical follow-up of a group of hypertensive patients during the year after finishing a therapeutic study with a new hypotensive drug]. Revista clinica espanola, 1973, Feb-28, Volume: 128, Issue:4 Topics: Antihypertensive Agents; Blood Pressure; Debrisoquin; Evaluation Studies as Topic; Follow-Up Studies	1973
[New sympathoplegic antihypersensive agent: debrisoquin sulfate]. L'union medicale du Canada, 1973, Volume: 102, Issue:5 Topics: Antihypertensive Agents; Debrisoquin; Humans; Hypertension; Hypotension, Orthostatic; Isoquinolines	1973
[On the hypotensive effect of debrisoquin sulfate (Declinax)]. Revista de medicina de la Universidad de Navarra, 1973, Volume: 17, Issue:4 Topics: Adult; Aged; Blood Pressure; Debrisoquin; Drug Evaluation; Female; Humans; Hypertension; Isoquinolin	1973

debrisoquin and Blood Pressure, High